|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Immunotoxic potential of aeration lagoon effluents for the treatment of domestic and hospital wastewaters in the freshwater mussel Elliptio complanata显示文摘Municipal wastewaters are major sources of pollution for the aquatic biota. The purpose of this study was to determine the levels of some pharmaceutical products and the immunotoxic potential of a municipal wastewater aeration lagoon for the treatment of the domestic wastewaters of a small town with wastewater inputs from a 400-bed hospital complex. Endemic mussels were collected, caged and placed in the final aeration lagoon and at sites 1 km upstream and 1 km downstream of the effluent outfall in the receiving river for a period of 14 days. The results showed that the final aeration lagoon contained high levels of total coliforms, conductivity and low dissolved oxygen (2.9 mg/L) as well as detectable amounts of trimethoprim, carbamazepine, gemfibrozil, and norfloxacin at concentrations exceeding 50 ng/L. The lagoon effluent was indeed toxic to the mussel specimens, as evidenced by the appearance of mortality after 14 days (10% mortality), decreased mussel weight-to-shell-length ratio and loss of hemocyte viability. The number of adhering hemocytes, phagocytic activity, total nitrite levels and arachidonic cyclooxygenase activity were significantly higher in mussels placed in the final aeration lagoon. A multivariate analysis also revealed that water pH, conductivity, total coliforms and dissolved oxygen were the endpoints most closely linked with phagocytic activity, the amount of adhering hemocytes and loss of hemocyte viability. In conclusion, exposure of mussels to treated aerated lagoon wastewater is deleterious to freshwater mussels where the immune system is compromised. | Francois Gagné Chantale André Marlène Fortier Michel Fournier | 2012 | Journal of Environmental Sciences2012，24，5： | 4 |
| 3 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 4 | Thermal stability of 18650 size Li-ion cells containing LiBOB dectrolyte salt显示文摘 | Jiang J W Fortier H Reimers J N | 2004 | J ElectrochemSoc2004，151，4： | 1 |
| 5 | Use of oral contraceptive pills and Vulvar vestibulitis:a casecontrol study显示文摘 | Bouchard C Brisson J Fortier M | 2002 | Am J Epidemiol2002，156，3： | 1 |
| 6 | Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimen- sional matrix 显示文摘 | WORSTER A A BROWER-TOLAND B D FORTIER L A | 2001 | J Orthop Res2001，19，4： | 1 |
| 7 | Isolation and chondrocytic differentiation of equine bone marrowderived mesenchymal stem cells显示文摘 | Fortier LA Nixon AJ Williams J | | 0，，09： | 1 |
| 8 | Comparing and contrasting the properties of urethane/acrylic hybrids with those of corresponding blends of urethane dispersions and acrylic emulsions显示文摘 | Brown R A Coogan R G Fortier D G | 2005 | Progress in Organic Coatings2005，52，： | 1 |
| 9 | Hormone-sensitive lipaseindependent adipocyte lipolysis duringβ-adrenergic stimulation,fasting,and dietary fat loading显示文摘 | fortier M Wang S P Mauriege P | 2004 | Am J Physiol Endocrinol Metab2004，287，： | 1 |
| 10 | Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells 显示文摘 | FORTIER L A NIXON A J WILLIAMS J | 1998 | Am J Vet Res1998，59，9： | 1 |
| 11 | Numerical simulation of the impacts of climate warming on a permafrost mound显示文摘 | guteau S Fortier R Delisle G | 2004 | Permafrost and Periglaeial Processes2004，15，： | 1 |
| 12 | Acute effects of short-duration isolated static stretching or combined with dy- namic exercises on strength,jump and sprint performance显示文摘 | FORTIER J LATTIER G BABAULT N | 2013 | Sci Sport2013，28，5： | 1 |
| 13 | Comparison between sys- temic analgesia, continuous wound catheter analgesia and contin- uous thoracic paravertebral block : a randomised, controlled trial of postthoracotomy pain management 显示文摘 | Fortier S Hanna HA Bernard A | 2012 | Eur J Anaesthesiol2012，29，11： | 1 |
| 14 | Prostaglandin E2 regulates both interleukin-2 and granulocyte-macrophage colonystimulating factor gene expression in bovine lymphocytes 显示文摘 | Emond V Fortier M A Murphy B D | 1998 | Biol Reprod1998，58，1： | 1 |
| 15 | Export of biogenic carbon to fish and to the deep ocean: the role of large planktonic mirophages显示文摘 | FORTIER L LE FeVRE J LEGENDRE L | 1994 | JournalofPlanktonResearch1994，16，： | 1 |
| 16 | Isolation and chondrocytic differentiation of equine bone marrow - derived mesenchymal stem cells显示文摘 | Fortier LA Nixon AJ Williams J | 1998 | Am J Vet Res1998，59，9： | 1 |
| 17 | The role of growth factors in cartilage repair显示文摘 | FORTIER L A BARKER J U STRAUSS E J | 2011 | Clin Orthop Relat Res2011，469，10： | 1 |
| 18 | Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury显示文摘 | Fortier AM Riopel K Desaulniers M | | 0，，02： | 1 |
| 19 | Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis withADHD and methylphenidate treatment response显示文摘 | Fortier MI Sengupta SM Grizenko N | 2013 | Neuromolecular Med2013，15，1： | 1 |
| 20 | Ectopic Pregnancy in a Cesarean Sear: a Case Report显示文摘 | Persadie R J Fortier AoStopps R G | 2005 | J Obstet Gynaecol Can2005，27，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员