|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | OPTICAL PROPERTIES OF SKIN,SUBCUTANEOUS,AND MUSCLE TISSUES:A REVIEW显示文摘The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated tissues.In this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is presented.Basic principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined. | ALEXEY N.BASHKATOV ELINA A.GENINA VALERY V.TUCHIN | 2011 | Journal of Innovative Optical Health Sciences2011，4，1： | 8 |
| 2 | Multispectral sensing of biological liquids with hollow-core microstructured optical fibres显示文摘The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance.This common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain.Here,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells.IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral ranges.We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs. | Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan Gnusov Vsevolod Atkin Ekaterina N.Lazareva Sergei V.German Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel Ginzburg Valery V.Tuchin Pavlos G.Lagoudakis Dmitry A.Gorin | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 3 | Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound显示文摘The cerebral blood flow(CBF) alterations related to sound-induced opening of the blood–brain barrier(BBB) in adult mice are studied using laser speckle contrast imaging(LSCI) and wavelet analysis of vascular physiology.The results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB. | O.Semyachkina-Glushkovskaya A.Abdurashitov A.Pavlov A.Shirokov N.Navolokin O.Pavlova A.Gekalyuk M.Ulanova N.Shushunova A.Bodrova E.Saranceva A.Khorovodov I.Agranovich V.Fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin | 2017 | Chinese Optics Letters2017，15，9： | 3 |
| 4 | Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy显示文摘Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms.Among the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms.Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia.The aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms.It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant S.aureus strain.Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs.The e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation.It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen.The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT. | Aram G.Gyulkhandanyan Marina H.Paronyan Anna G.Gyulkhandanyan Karapet R.Ghazaryan Marina V.Parkhats Boris M.Dzhagarov Maria V.Korchenova Ekaterina N.Lazareva Elena S.Tuchina Grigor V.Gyulkhandanyan Valery V.Tuchin | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 1 |
| 5 | FOREWORD显示文摘Special Issue Optical Technologies in the Study of Tissues and Biological Fluids We are pleased to present this special issue of JIOHS,which focuses on optical technologies in the study of tissues and biological liquids.The selected papers were presented during Saratov Fall Meeting—XII International School for Junior Scientists and Students on Optics,Laser Physics and Biophotonics(September 23–26,2008,Saratov,Russia)in the framework of the following workshops:“Optical Technologies in Biophysics and Medicine,”“Nanostructures and Nanoparticles,”“Microscopic and Low-Coherence Methods in Biomedical Applications,”and“Internet Biophotonics.”All eight papers in this special issue are research papers. | Elina A.Genina Kirill V.Larin Valery V.Tuchin | 2009 | Journal of Innovative Optical Health Sciences2009，2，3： | 0 |
| 6 | Introduction to the special issue on celebrating the 15th anniversary of JIOHS and the 70th anniversary of HUST显示文摘Since launching in 2008,Journal of Innovative Optical Health Sciences(JIOHS)has been published for 15 years umtil 2022.Supported by the founding advisor Prof.Britton Chance and other founding Editorial Members,JIOHS was quickly embraced by the biomedical optics community,especially in Asia.Authors submitted some of their high quality papers to JIOHS,which led to a constant Impact Factor(IF)increase frcom the first IF 0.632 to IF 2396(Journal Citation Report 2021). | Qingming Luo Valery V.Tuchin Lihong Wang | 2023 | Journal of Innovative Optical Health Sciences2023，16，1： | 0 |
| 7 | COMPARATIVE TREATMENT OF ACNE VULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION显示文摘Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne lesions.However,invasive delivery techniques limit the use of this modality to a relatively narrow class of cases.Skin permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of epidermis.In this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne lesions.Clinical photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the study.No difference in lesion dynamics between the treatment and control groups was observed at two-hours follow-up.At 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne lesions.Enhancement of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin. | ELINA A.GENINA ALEXEY N.BASHKATOV VALERY V.TUCHIN GEORGY V.SIMONENKO VERA N.SHERSTNEVA ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER | 2009 | Journal of Innovative Optical Health Sciences2009，2，3： | 0 |
| 8 | Introduction to the Special Issue on Advances in Biophotonics and Biomedical Optics:Part II显示文摘The 9th Chinese–Russian Workshop on Biophotonics and Biomedical Optics was held online on 28–30 September 2020.The bilateral workshop brought together both Russian and Chinese scientists,engineers,and clinical researchers from a variety of disciplines engaged in applying optical science,photonics,and imaging technologies to problems in biology and medicine.During the workshop,2 plenary lectures,35 invited presentations,5 oral presentations,and 8 internet reports were presented.This special issue selects some papers from the attendees and includes both research and review articles. | Polina Dyachenko(Timoshina) Tingting Yu Dan Zhu Valery V.Tuchin | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 0 |
| 9 | Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral°uid dynamics显示文摘Photodynamic therapy(PDT)is a promising tool for least-invasive alternative methods for the treatment of brain tumors.The newly discovered PDT-induced opening of the blood–brain barrier(BBB)permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM.Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability,including with formation of brain edema.The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules.We discuss that noninvasive photonic stimulation of°uid clearance via meningeal lymphatic vessels,and application of optical coherence tomography(OCT)for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors. | A.Abdurashitov V.Tuchin O.Semyachkina-Glushkovskaya | 2020 | Journal of Innovative Optical Health Sciences2020，，2： | 0 |
| 10 | ASSESSMENT OF TISSUE OPTICAL CLEARING AS A FUNCTION OF GLUCOSE CONCENTRATION USING OPTICAL COHERENCE TOMOGRAPHY显示文摘One of the major challenges in imaging biological tissues using optical techniques,such as optical coherence tomography(OCT),is the lack of light penetration due to highly turbid structures within the tissue.Optical clearing techniques enable the biological samples to be more optically homogeneous,allowing for deeper penetration of light into the tissue.This study investigates the effect of optical clearing utilizing various concentrations of glucose solution(10%,30%,and 50%)on porcine skin.A gold-plated mirror was imaged beneath the tissue and percentage clearing was determined by monitoring the change in reflected light intensity from the mirror over time.The ratio of percentage clearing per tissue thickness for 10%,30% and 50% glucose was determined to be 4.7±1.6%mm^(−1)(n=6),10.6±2.0%mm^(−1)(n=7)and 21.8±2.2%mm^(−1)(n=5),respectively.It was concluded that while higher glucose concentration has the highest optical clearing effect,a suitable concentration should be chosen for the purpose of clearing,considering the osmotic stress on the tissue sample. | NARENDRAN SUDHEENDRAN MOHAMED MOHAMED MOHAMAD G.GHOSN VALERY V.TUCHIN KIRILL V.LARIN | 2010 | Journal of Innovative Optical Health Sciences2010，3，3： | 0 |
| 11 | INTRODUCTION SPECIAL ISSUE:OPTICAL CLEARING FOR BIOMEDICAL IMAGING显示文摘In the visible and near-infrared wavelength range,the majority of tissues are low absorbing but highly scattering media.Scattering defines the penetration depth of light in tissue,and also limits the clinical application of light-based diagnostic and therapeutic techniques.Optical clearing agents(OCAs)have been identified that can reversibly change the light scattering properties of tissues and blood. | Valery V.Tuchin Martin Leahy Dan Zhu | 2010 | Journal of Innovative Optical Health Sciences2010，3，3： | 0 |
| 12 | INTRODUCTION:SPECIAL ISSUE ON ADVANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART I显示文摘The 5th Russian-Chinese Workshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,2012.The bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and medicine.During the W orkshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters was also organized.This special issue selects some papers from the attendees,and is made up of 12 original research articles and one review.Seven articles will be presented in Vol.6 No.1 of JIOHS,while the remaining five articles will be presented in Vol.6 No.2. | Dan Zhu Valery V.Tuchin Qingming Luo | 2013 | Journal of Innovative Optical Health Sciences2013，6，1： | 0 |
| 13 | Integrated binary hologram to monitor cargo release from a drug-eluting film显示文摘Nowadays,holography translates from a pure technical tool for recording the phase and amplitude of the light wave to a widely applicable research-based method.Holographic devices are used for security enhancement,entertainment,3D display technologies and augmented reality.Binary computer-generated holograms(amplitude or phase-based)are of specific interest.They are easy to compute and their manufacturing methods are fast and robust.In this work,a method of manufacturing amplitude-only binary holograms out of biopolymers films is proposed.Opaque cargo bits made out of different bioactive substances(antibiotics,dyes,etc.)absorb or scatter specific parts of the incoming light wave.Cargo release was conducted by submerging the produced holograms into the aqueous solution at specific pH and temperature levels.Drug elution from the film was traced out by the numerical analysis of the far-field diffraction pattern,which otherwise could only be measured post-factum using sophisticated spectroscopic or chromatography devices.This approach broadens the application of general holography over to the field of biomedical research relevant to quantitative monitoring of the drug elution. | Arkady S.Abdurashitov Pavel IProshin Valery V.Tuchin Gleb B.Sukhorukov | 2022 | Light(Advanced Manufacturing)2022，3，3： | 0 |
| 14 | INTRODUCTION:SPECIAL ISSUE ON ADV ANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART II显示文摘The 5th Russian-Chinese W orkshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,2012.The bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and medicine.During the Workshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters,was also organized.This special issue selects some papers from the attendees,and is made up of 12 original research articles and one review.Seven articles have been presented in Vol.6,No.1 of JIOHS;this issue presents the remaining six articles. | Dan Zhu Valery V.Tuchin Qingming Luo | 2013 | Journal of Innovative Optical Health Sciences2013，6，2： | 0 |
| 15 | OPTICAL COHER ENCE TOMOGRAPHY OF ADIPOSE TISSUE AT PHOTODYNAMIC/PHOTOTHERMAL TRE ATMENT IN VITRO显示文摘Temporal changes in structure and refractive index distribution of adipose tissue at photo-dynamic/photothermal treatment were studied with OCT in vitro.Ethanol-water solutions of indocyanine green(ICG)and brilliant green(BG)were used for fat tissue staining.CW laser diode(808 nm)and LED light source(442 and 597 nm)were used for ir adiation of stained tissue slices.The data received supporting the hypothesis that photodynamic/photothermal treatment,induces fat cell lipolysis during a certain period of time after light exposure. | IRINA YU.YANINA NATALIA A.TRUNINA VALERY V.TUCHIN | 2013 | Journal of Innovative Optical Health Sciences2013，6，2： | 0 |
| 16 | THE EXPERIMENTAL STUDY OF STRESS-RELATED PATHOLOGICAL CHANGES IN CEREBRAL VENOUS BLOOD FLOW IN NEWBORN RATS ASSESSED BY DOCT显示文摘In experiments on newbom rats with stress related intracrani al hemorhage(ICH)using Doppler optical coberence tomognaphy(DOCT)we have shown that latent stage of ICH(4 h after stress)is characterized by decrease of venous blood outflow and the loss of sensitivity of sagittal vein to vasoconstrictor ffect of adrenaline.The incidence of ICH(24 h after stress)was accompanied by progressi on of early pathological changes in cerebral venous blood flow(CVBF)and development of venous insufficiency.Taking into consideration of this fact,we suggest that the suppression of CVBF related to the severity to the deleterious effect of stress on the brain hemodynamics in newborn rats.These facts allow us to conclude that the venous insufficiency with the loss of vasoconstrictor response to adrenaline is an informative and sensitive component of pattern of CVBF that can be important diagnostic criteria of risk of ICH development in newborns. | OXANA V.SEMYACHKINA-GLUSHKOVSKAYA VLADISLAV V.LYCHAGOV OLGA A.BIBIKOVA IGOR A.SEMYACHKIN-GLUSHKOVSKIY SERGEY S.SINDEEV EKATERINAM.ZINCHENKO MOHHANAD M.KASSIM AL-FATLE FATEMA ALI AL HASSANI LEITH MARIA V.ULANOVA VALERY V.TUCHIN | 2013 | Journal of Innovative Optical Health Sciences2013，6，3： | 0 |
| 17 | WAVELET-BASED ANALYSIS OF CEREBROVASCULAR DYNAMICS IN NEWBORN RATS WITH INTRACRANIAL HEMORRHAGES显示文摘Intracranial hemorrhage(I)is a major problem of neonatal intensive care.The incidence of Iistypically asymptomatic and'canmot be effectively detected by standard diagnostic methods.The mechanisms underlying IH are unknown but there is evidence that stress-induced disorders inadrenergic regulation of cerebral venous blood flow (CVBF) are among the main reasons.Quantitative and qualitative:could significantly advance understanding ofthe nature of I in newbornslth1sions of CVBF in newborn rats withan experimental model of stinjection.Our analysis is bas ed on theDoppler optical coheavelet-based approachthat provides sensitiv external factors.Theobtained resultsccompanied by asupprectivity to adrenaline.Weintroducd show that the values0<1.23 estimated ithelodinto the sympathicusindicate abnormal reactions associated with the developent of I.We conclude that t he revealed areactivity of the cerebral veins to adrenaline represents a possible mechanism responsible forpat hological changes in CVBF. | ALEXEY N.PAVLOV ALEXEY I.NAZIMOV OLGA N.PAVLOVA VLADISLAV V.LYCHAGOV VALERY V.TUCHIN OLGA A.BIBIKOVA SERGEYS.SINDEEV OXANA V.SEMYACHKINA-GLUSHKOVSKAYA | 2014 | Journal of Innovative Optical Health Sciences2014，7，1： | 0 |
| 18 | Terahertz technology in intraoperative neurodiagnostics:A review显示文摘Terahertz(THz)technology offers novel opportunities in biology and medicine,thanks to the unique features of THzwave interactions with tissues and cells.Among them,we particularly notice strong sensitivity of THz waves to the tissue water,as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging.Tissues of the brain have an exceptionally high content of water.This factor,along with the features of the structural organization and biochemistry of neuronal and glial tissues,makes the brain an exciting subject to study in the THz range.In this paper,progress and prospects of THz technology in neurodiagnostics are overviewed,including diagnosis of neurodegenerative disease,myelin deficit,tumors of the central nervous system(with an emphasis on brain gliomas),and traumatic brain injuries.Fundamental and applied challenges in study of the THz-wave–brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed. | Nikita V.Chernomyrdin Guzel R.Musina Pavel V.Nikitin Irina N.Dolganova Anna S.Kucheryavenko Anna I.Alekseeva Yuye Wang Degang Xu Qiwu Shi Valery V.Tuchin Kirill I.Zaytsev | 2023 | Opto-Electronic Advances2023，6，5： | 0 |
| 19 | PHOTOTHERAPY OF GINGIVITIS:PILOT CLINICAL STUDY显示文摘The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were conducted.The microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the R-LETB.For the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two groups.Subjects in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized toothpaste.The second(control)group used only the toothpaste and a regular toothbrush.Subjects in both groups followed their respective procedures 2 times a day(morning and evening)for 30 days.Indices of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day timepoints.In the both groups,all indices improved in comparison with baseline.However,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum tissue.Thus,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction. | ELINA A.GENINA VLADIMIR A.TITORENKO VALERY V.TUCHIN GEORGY V.SIMONENKO ALEXEY N.BASHKATOV GENNADY M.SHUB ALEXANDER V.LEPILIN ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER | 2011 | Journal of Innovative Optical Health Sciences2011，4，4： | 0 |
| 20 | Foreword to the Special Issue on Optical Technologies in Biophysics and Medicine显示文摘We are pleased to present the third issue of JIOHS,which focuses on optical technologies of diagnosticsand therapy,These are selected papers presented during Saratov Fall Meeting,1t International Sym-posium on Optics and Biophotonics(September 24-28,2013,Saratov,Russia)in the framework of the Workshops:'Optical Technologies in Biophysics_and Medicine,'Nanobiophotonics,'and'Internet Biophotonics.' | Elina A.Genina Dan Zhu Valery V.Tuchin | 2015 | Journal of Innovative Optical Health Sciences2015，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员