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| 1 | Long-term thermal regimes of the Qinghai-Tibet Railway embankments in plateau permafrost regions显示文摘Ten years of ground temperature data(2003–2013) indicate that the long-term thermal regimes within embankments of the Qinghai-Tibet Railway(QTR) vary significantly with different embankment structures. Obvious asymmetries exist in the ground temperature fields within the traditional embankment(TE) and the crushed-rock basement embankment(CRBE). Measurements indicate that the TE and CRBE are not conducive to maintaining thermal stability. In contrast, the ground temperature fields of both the crushed-rock sloped embankment(CRSE) and the U-shaped crushed-rock embankment(UCRE) were symmetrical. However, the UCRE gave better thermal stability than the CRSE because slow warming of deep permafrost was observed under the CRSE. Therefore, the UCRE has the best long-term effect of decreasing ground temperature and improving the symmetry of the temperature field. More generally, it is concluded that construction using the cooling-roadbed principle meets the design requirements for long-term stability of the railway and for train transport speeds of 100 km h?1. However, temperature differences between the two shoulders, which exist in all embankments shoulders, may cause potential uneven settlement and might require maintenance. | NIU Fu un LIU MingHao CHENG GuoDong LIN ZhanJu LUO Jing YIN GuoAn | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 2 | Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4显示文摘 | Un Luo Ze-Ping Yu Han Qin Ze-Xin Zhu Ming-Heng Liao Hao-Tian Liao Ke-Fei Yuan Yong Zeng | 2018 | Chinese Medical Journal2018，，4： | 5 |
| 3 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 4 | Improved energy storage density in barium strontium titanate by addition of BaO-SiO2-B2O3 glass显示文摘 | Zhang Qingmeng Wang Lei Luo J un | 2009 | J Am Ceram Soc2009，92，8： | 1 |
| 5 | New amide alkaloids from Piper longum fruits显示文摘 | Yang J un Su Yao Luo Jifertg l | 2013 | Nat Prod Bioprospect2013，3，： | 1 |
| 6 | Gaseous air pollution and acute myocardial infarction mortality in Hong Kong:A time-stratified casecrossover study显示文摘 | UN H L AN Q Z LUO C | 2013 | Atmos Environ2013，，： | 1 |
| 7 | Characterization of two tartary buckwheat R2R3‐MYB transcription factors and their regulation of proanthocyanidin biosynthesis显示文摘 | Yue‐Chen Bai Cheng‐Lei Li Jin‐Wen Zhang Shuang‐Jiang Li Xiao‐Peng Luo Hui‐Peng Yao Hui Chen Hai‐Xia Zhao Sang‐Un Park Qi Wu | 2014 | Physiol Plantarum2014，，3： | 1 |
| 8 | An Inhibitory Effect of MAD1 on Bladder Tumor Cellular Proliferation in Vivo显示文摘OBJECTIVE To observe the inhibitory effect on bladder tumor prolivera-tion after transfection with the expression plasmid pcDNA3.1(+)/Mad1. METHODS Bladder tumors were induced in SD rats by intravesical instillation of MNU . The tumor-bearing rats were randomly divided into 3 groups: group A, transfected with pcDNA3.1 (+)/Mad1, group B, trans-fected with an empty vector and group C, transfected with saline. Rat body weight (RBW), bladder absolute weight (BAW) and bladder relative weight (BRW) were measured and expression levels of Mad1 and TERT were assayed. Flow cytometer analysis was used to observe the effect of Mad1 on the bladder tumors. RESULTS Comparions of RBW among the 3 groups showed there were no differences (P>0.05). But the BAW and BRW for group A were significantly decreased (P<0.01, P<0.05, respectively) comparded to groups B and C. In group A, the Mad1 mRNA expression level was markedly improved, while the TERT mRNA expression level was decreased. Flow cy-tometry showed an increase in G0/G1-phase cells and a decrease of S-phase cells after transfection with Mad1. CONCLUSION Over expression of Mad1 can inhibit the cellular proliferation of bladder tumors. | Hongbo Hu Chunli Luo Xiaozhong Cai Un Zou Pei Zhao Xiouhou Wu | 2006 | Chinese Journal of Clinical Oncology2006，3，2： | 0 |
| 9 | Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP显示文摘Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little effect.Together, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner. | Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng Zhang Fei Li Yiqing Wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin Zhang Chunbo Zhang Shuo Tu Zhihua Li Zhijun Luo Zhenghong Lin Xiaohua Yan | 2023 | Journal of Molecular Cell Biology2023，15，2： | 0 |
| 10 | Research of Anti-sway System for ARMG Based on Input-shaping Control Method显示文摘 | Gang Liu Jingui Luo Ch un Xie Christian Sponfeldner | 2015 | 机械工程与设计(中英文版)2015，4，1： | 0 |
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