|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Global signatures of protein binding on structured RNAs in Saccharomyces cerevisiae显示文摘Protein binding is essential to the transport,decay and regulation of almost all RNA molecules.However,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly understood.Here,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide resolution.We found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by proteins.The RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in vivo.We found that four nucleotide modifications of tRNA are significantly associated with RBP binding.We also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress responses.Moreover,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary structures.We present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions. | YANG YuCheng UMETSU Jumpei LU Zhi John | 2014 | Science China(Life Sciences)2014，57，1： | 7 |
| 2 | Early exposure to germs and the Hygiene Hypothesis显示文摘 | Dale T Umetsu | 2012 | Cell Research2012，22，8： | 4 |
| 3 | Orosomucoid (ORM) typing by isoelectric focusing: evidence for two structural loci ORM1 and ORM2显示文摘 | I. Yuasa K. Umetsu K. Suenaga M. Robinet-Levy | 1986 | Human Genetics1986，，2： | 4 |
| 4 | Orosomucoid (ORM) typing by isoelectric focusing: description of two new alleles in a German population and thermostability in bloodstains显示文摘 | K. Umetsu I. Yuasa K. Nishi B. Brinkmann T. Suzuki | 1989 | Zeitschrift für Rechtsmedizin (-)1989，，2： | 3 |
| 5 | Orosomucoid (ORM) typing by isoelectric focusing: evidence for gene duplication of ORM1 and genetic polymorphism of ORM2显示文摘 | I. Yuasa K. Suenaga K. Umetsu K. Ito M. Robinet-Levy | 1987 | Human Genetics1987，，3： | 3 |
| 6 | Magnetic relaxation behavior of a spatially closed dysprosium(Ⅲ) phthalocyaninato double-decker complex显示文摘The SMM properties of the spatially closed Dy(Ⅲ) double-decker Pc complex Dy(obPc) 2 (1), which is equivalent to a pseudo dinuclear complex, are reported. Complex 1 crystallized with ethanol in the crystal lattice in the monoclinic space group P21/n and was isomorphous with Tb(obPc) 2 (3), which is arranged in a dimer structure along the b axis. The intermetallic Dy-Dy distance was determined to be 0.756 nm. χM T versus T plots for 1 decreased with a decrease in T, which suggests the existence of an antiferromagnetic (AF) interaction between the Dy 3+ ions. The M-H curve for 1 at 1.8 K showed magnetic hysteresis. In ac susceptibility measurements on a powder sample of 1, which were dependent on the applied ac field, indicating that 1 is an single molecule magnet (SMM), a maximum appeared at 22 K at an ac frequency (f) of 1488 Hz. The shape of the peaks drastically changed, and the peaks did not shift when an H dc large enough to suppress the quantum tunneling of the magnetization (QTM) was applied. The energy barrier (△/hc) was estimated to be 44 cm-1 with a pre-exponential factor (τ0 ) of 1.6 × 10 -5 s from an Arrhenius plot. Our results suggest that the SMM/magnetic properties of 1 significantly change in a dc magnetic field. These relaxation mechanisms are related to the energy gap of the ground state and to QTM. | KATOH Keiichi UMETSU Kaori BREEDLOVE BRIAN K. YAMASHITA Masahiro | 2012 | Science China Chemistry2012，55，6： | 3 |
| 7 | Genetic polymorphisms of orosomucoid and alpha-2-HS-glycoprotein in Thai, Sri Lankan and Paraguayan populations显示文摘 | Kazuo Umetsu Isao Yuasa Takao Yamashita Susumu Saito Tomio Yamaguchi Srinama B. Ellepola Takafumi Ishida Tsuneo Suzuki | 1989 | The Japanese Journal of Human Genetics1989，，3： | 2 |
| 8 | Structure and properties of nanoporous FePt fabricated by dealloying a melt-spun Fe(60)Pt(20)B(20)alloy and subsequent annealing显示文摘A nanoporous FePt alloy has been fabricated by dealloying a melt-spun Fe(60)Pt(20)B(20)alloy composed of nanoscale amorphous and face-centered-cubic FePt(fcc-FePt)phases in H2 SO4 aqueous solution.The nanoporous alloy consists of single fcc-FePt phase with an Fe/Pt atomic ratio of about 55.3/44.7,and possesses a uniform interpenetrating ligament-channel structure with average ligament and pore sizes of 27 nm and 12 nm,respectively.The nanoporous fcc-FePt alloy shows soft magnetic characteristics with a saturation magnetization of 37.9 emu/g and better electrocatalytic activity for methanol oxidation than commercial Pt/C in acidic environment.The phase transformation from disordered fcc-Fe Pt into ordered face-centered-tetragonal FePt(L10-FePt)in the nanoporous alloy has been realized after annealing at823-943 K for 600 s.The volume fraction of the L10-FePt phase in the alloy increases with the rise of annealing temperature,which results in the enhancements of coercivity and saturation magnetization from 0.14 kOe and 38.5 emu/g to 8.42 kOe and 51.4 emu/g,respectively.The ligament size of the samples is increased after annealing. | Dianguo Ma Yingmin Wang Yanhui Li Rie Y·Umetsu Shuli Ou Kunio Yubuta Wei Zhang | 2020 | Journal of Materials Science & Technology2020，36，1： | 2 |
| 9 | Inhibition of the allergic response by regulatory T cells 显示文摘 | Stock P DeKruyff RH Umetsu DT | 2006 | Curr Opin Allergy Clin Immunol2006，6，1： | 1 |
| 10 | The TIM gene family:emerging roles in immunity and disease显示文摘 | Umetsu DT DeKruyff RH | 2003 | Nat Rev Immunol2003，3，： | 1 |
| 11 | TIM family of genes in immunity and tolerance 显示文摘 | Kuchroo V K Meyers J H Umetsu D T | 2006 | Adv Immunol2006，91，： | 1 |
| 12 | Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respirato ry exposure to antigen显示文摘 | Akbari O DeKruyff RH Umetsu DT | 2001 | Nat Immunol2001，2，： | 1 |
| 13 | Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen显示文摘 | Akbari O DeKruyff RH Umetsu DT | 2001 | Nat Immunol2001，2，8： | 1 |
| 14 | Finite element method for moving boundary problems in river flow 显示文摘 | KAWAHARA M UMETSU T | 1986 | International Journal for Numerical Methods in Fluids1986，6，6： | 1 |
| 15 | Mg-Al layered double hydroxide intercalated with ethylene-diaminetetraacetate anion:Synthesis and application to the uptake of heavy metal ions from an aqueous solution显示文摘 | Kameda T Saito S Umetsu Y | | 0，，1： | 1 |
| 16 | Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen显示文摘 | DeKruyff RH Umetsu DT | 2001 | Nat Immunol2001，2，： | 1 |
| 17 | Regulatory T cells control the development of allergic diseases and asthma显示文摘 | Umetsu DT Akbari O Dekruyff RH | 2003 | J Allergy Clin Immunol2003，112，： | 1 |
| 18 | Allergen immunotherapy : novel approaches in the management of allergic diseases and asthma 显示文摘 | Campbell D De Kruyff RH Umetsu DT | 2000 | Clin Immunol2000，97，3： | 1 |
| 19 | Debittefing Mechanism of Bitter Peptides from Milk Casein by Wheat Carboxy-Peptidase 显示文摘 | UMETSU H | 1983 | Agric Food Chem1983，31，1： | 1 |
| 20 | Allergen immunotherapy: novel approaches in the management of allergic diseases andasthma显示文摘 | Campbell D DeKruyff RH Umetsu DT | 2000 | Clin Immunol2000，97，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员