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| 1 | SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity显示文摘There is a link between high lipopolysaccharide(LPS)levels in the blood and the metabolic syndrome,and metabolic syndrome predisposes patients to severe COVID-19.Here,we define an interaction between SARS-CoV-2 spike(S)protein and LPS,leading to aggravated inflammation in vitro and in vivo.Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS.Microscale thermophoresis yielded a of〜47 nM for the interaction.Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results,identifying a main LPS-binding site in SARS-CoV-2 S protein.S protein,when combined with low levels of LPS,boosted nuclear factor-kappa B(NF-k B)activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells,respectively.The in vitro inflammatory response was further validated by employing NF-kB reporter mice and in vivo bioimaging.Dynamic light scattering,transmission electron microscopy,and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS,providing a molecular explanation for the observed boosting effect.Taken together,our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins. | Ganna Petruk Manoj Puthia Jitka Petrlova Firdaus Samsudin Ann-Charlotte Stromdahl Samuel Cerps Lena Uller Sven Kjellstrom Peter J.Bond Artur Schmidtchen | 2020 | Journal of Molecular Cell Biology2020，12，12： | 3 |
| 2 | Screening of commercial sorbents for the removal of reactive dyes显示文摘 | Karcher S Komm&Uller A Jekel M | 2001 | Dyes and Pigments2001，51，23： | 1 |
| 3 | 查看详情显示文摘 | Kresse G Furthm ¨uller J | | 0，，： | 1 |
| 4 | Non-linear component analysis as a kernel eigenvalue problem显示文摘 | Sch¨olkopf B Smola A M¨uller K | | 0，，： | 1 |
| 5 | Remodeling of extrabronchial lung vasculature following allergic airway inflammation 显示文摘 | Rydell-Tormanen K Uller L Erjefalt JS | 2008 | RespirRes2008，9，： | 1 |
| 6 | Biologic fixation of a press-fit titanium hip joint endoprosthesis显示文摘 | Zweym¨uller KA Lintner FK Semlitsch MF | | 0，，： | 1 |
| 7 | Splat-based ray tracing of point clouds 显示文摘 | Linsen L M'uller K Rosenthal P | 2007 | Journal of WSCG2007，15，2： | 1 |
| 8 | Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration 显示文摘 | Erjefalt JS Uller L Malm-Erjefalt M | 2004 | Thorax2004，59，2： | 1 |
| 9 | Template-mediated self-assembly of six-and eight-membered iron coronates显示文摘 | Saalfrank R W Bernt I Uller E Hampel F | | 0，，： | 1 |
| 10 | Ground-state properties of alkali dimers and their cations (including the elements Li, Na, and K) from ab initio calculations with effective core polarization potentials显示文摘 | M uller W Meyer W | 1984 | J Chem Phys1984，80，： | 1 |
| 11 | 显示文摘 | Schrefl T Fidler J Kromm uller H | 1994 | Phys Rey B1994，49，9： | 1 |
| 12 | Developmental plasticity and the evolution of parental effects 显示文摘 | Uller T | 2008 | Trends in Ecology and Evolution2008，23，8： | 1 |
| 13 | An economic evaluation based on an experimental study of the vitamin E concentration present in deodorizer distillate of soybean oil using supercritical CO2 显示文摘 | MENDES M F PESSOA F L P ULLER A M C | 2002 | The Journal of Supercritical Fluids2002，23，3： | 1 |
| 14 | Fractures of the distalhumerus in the adult显示文摘 | Uller ME Allgower M Schneider R | 2000 | Clin Orthop2000，31，： | 1 |
| 15 | Parental effects in ecology and evolution: mechanisms, processes and implications显示文摘 | Badyaev Alexander V Uller Tobias | 2009 | Philosophical Transactions of The Royal Society B . 2009 (1520)2009，，： | 1 |
| 16 | Towards an evolutionary ecology of sexual traits显示文摘 | Charlie K. Cornwallis Tobias Uller | 2009 | Trends in Ecology & Evolution2009，，： | 1 |
| 17 | Listening in aging adults: from discourse comprehension to psychoacoustics显示文摘 | SCHNEIDER B A DANEMAN M PICHORAF- ULLER M K | 2002 | Can J ExpPsyehol2002，56，： | 1 |
| 18 | Antagonism ofthe prostaglandin D2 receptorCRTH2 attenuates asthma pathologyin mouse eosinophilicairway inflammation显示文摘 | ULLER L MATHIESEN JM ALENMYR L | 2007 | Respir Res2007，8，： | 1 |
| 19 | Assessment of a novel screening score for nutritional risk in predicting complications in gastro-intestinal surgery显示文摘 | Schiesser M M uller S Kirchhoff P | 2008 | Clin Nutr2008，27，4： | 1 |
| 20 | Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps 显示文摘 | Uller L Andersson M Greiff L | 2004 | Am Respir Crit Care Med2004，170，7： | 1 |
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