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| 1 | Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration显示文摘Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood vessels.Mesenchymal stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans.Exosomes,which are among the key products MSCs release,mimic the effects of parental MSCs.They can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound healing.Moreover,using exosomes avoids many risks associated with cell transplantation.Therefore,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole cell.In this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration.In addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications.This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini | 2019 | Burns & Trauma2019，7，1： | 20 |
| 2 | Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer's disease progression?显示文摘Astrocytes' roles in late-onset Alzheimer's disease(LOAD) promotion are important, since they survive soluble or fibrillar amyloid-β peptides(Aβs) neurotoxic effects, undergo alterations of intracellular and intercellular Ca2+ signaling and gliotransmitters release via the Aβ/α7-n ACh R(α7-nicotinic acetylcholine receptor) signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/Ca SR(calcium-sensing receptor) signaling. Recently, it was suggested that the NMDAR(N-methyl-D-aspartate receptor) inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-n ACh R signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric Ca SR antagonist(calcilytic). | Ilaria Dal Prà Anna Chiarini Ubaldo Armato | 2015 | Neural Regeneration Research2015，10，2： | 6 |
| 3 | Catabolic cancer-associated fibroblasts (CAFs) transfer energy and biomass to anabolic cancer cells, fueling tumor growth显示文摘 | Ubaldo E. Martinez-Outschoorn Michael P. Lisanti Federica Sotgia | 2014 | Seminars in Cancer Biology2014，，： | 2 |
| 4 | Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia(Oreochromis niloticus)显示文摘Objective:To evaluate,in hyperglycemic tilapia[Oreochromis niloticus(O.niloticus)].the effect of this aqueous extract on blood glucose levels.Methods:The hyperglycemia in O.niloticus was induced by adding glucose to fish pond water.An aqueous extract of Ocimum tenuiflorum (O.tenuiflorum) was prepared by boiling fresh leaves and the doses of 0,40,80,200 and 400 mg per liter of pond water were tested.Results:The blood sugar concentration for tilapia with hyperglycemic induced was an average of 50%higher than the control group.The blood glucose levels in tilapia after the induction of hyperglycemia were higher than the control group for 90 min after the treatment.The treatment with the aqueous extract of O.tenuiflorum dropped the serum glucose level of hyperglycemic tilapia until it was similar to that of the control group and was dose dependent.Conclusions:The results indicated that O.tenuiflorum was endowed with anti-hyperglycemic activity.To our knowledge,this is the first report on the use of fish as a diabetes model to test natural extracts from plants. | Amilcar Arenal Leonardo Martín Nestor M Castillo Dainier de la Torre Ubaldo Torres Reinaldo Gonzlez | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 2 |
| 5 | II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: Co-milling显示文摘 | Lauretta Maggi Giovanna Bruni Mariarosa Maietta Andrea Canobbio Andrea Cardini Ubaldo Conte | 2013 | International Journal of Pharmaceutics2013，，： | 1 |
| 6 | Tuning electron-hole distance of the exeitons in organic molecules using tunctional groups显示文摘 | Wang Tianyang Weerasinghe Krishanthi C Ubaldo Pamela C | 2015 | Chemical Physics Letters2015，618，： | 1 |
| 7 | Fetal cardiac evaluation at 11-14 weeks by experienced obstetricians in a low-risk population显示文摘 | Volpe P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
| 8 | Metabolic remodeling of the tumor microenvironment migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth 显示文摘 | Valentina C Gloria B Ubaldo E | 2012 | Cell Cycle2012，11，18： | 1 |
| 9 | A case of intermittent lumbar pain radiating to the right shoulder in a 76-year-old woman (2009: 6b)显示文摘 | Luciano Cardinale Francesco Ardissone Ubaldo Familiari Mariaelena Perna Cesare Fava | 2009 | European Radiology2009，，9： | 1 |
| 10 | Continuous intestinal infu- sion of levodopa/carbidopa in advanced Parkinson's disease : effica, cy, safety and patient selection 显示文摘 | Giovanni A Paolo B Ubaldo B | 2012 | Funct Neurol2012，27，： | 1 |
| 11 | Vali-dation methods to determine phyticand oxalic acids in ' multimistur-as” 显示文摘 | Sandberg A S Giancarlo Ubaldo Nappi Lieselotte Jokl | 1989 | Food science1989，，： | 1 |
| 12 | Continuous intestinal infusion of levodopaJcarbidopa in advanced Parkinson's disease:efficacy, safety and patient selection 显示文摘 | Giovanni Abbruzzese Paolo Barone Ubaldo Botxuccelli | 2012 | Funct Neurol2012，27，3： | 1 |
| 13 | Fetal cardiac evaluation at 11-14weeks by experienced obstetricians in a low-risk population显示文摘 | Volpe P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
| 14 | Pulsed field gradient spin-echo NMR measurement of water diffusion coefficient in thickening and gelling agents:guar galactomannan solutions and pectin gels显示文摘 | Brosio E D'Ubaldo A Verzegnassi B | 1994 | Cell Mol Biol1994，40，： | 1 |
| 15 | Neurotrophin p75 receptor is involved in neuronal damage by Prion peptide (106-126)显示文摘 | Vittorina Della Bianca Filippo Rossi Ubaldo Armato | 2002 | J Biol Chem2002，276，38： | 1 |
| 16 | Fetal cardiac evaluation at 11 -14 weeks by experienced obstetricians in a low-risk population 显示文摘 | Volpe P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
| 17 | Fetal cardiac evaluation at 11 -14 weeks by experienced obstetricians in a low -risk population显示文摘 | Volpe P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
| 18 | Chemical structure and compatibility of polyamide-chitin and chitosan blends显示文摘 | Virgilio Gonzalez Carlos Guerrero Ubaldo Ortiz | 2000 | J Appl Polym Sci2000，78，4： | 1 |
| 19 | Fetal cardiac evaluation at11-14 weeks by experienced obstetricians in a low-risk population显示文摘 | Volpe P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
| 20 | Fetal cardiac evaluation at 11-14 weeks by experienced obstetricians in a low-risk population显示文摘 | Volep P Ubaldo P Volpe N | 2011 | Prenat Diagn2011，31，11： | 1 |
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