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| 1 | Necroptosis was found in a rat ischemia/reperfusion injury flap model显示文摘Background:Necroptosis is a new form of cell death that has been identified as a third pathway causing cell death.In this study,necrostatin-1 (Nec-1) was used to determine whether necroptosis exists in a rat ischaemia/reperfusion injury flap model.Methods:In this study,twenty male Sprague-Dawley rats were divided randomly into two groups:a control group (CTL group) and a Nec-1 group.Each abdominal skin flap underwent 3 h of ischaemia and then reperfusion.Fifteen minutes before and after reperfusion,phosphate buffer saline (PBS) was administered intraperitoneally to the CTL group,while Nec-1 was administered intraperitoneally to the Nec-1 group.Twenty-four hours after reperfusion,the whole flap was divided equally into 54 sections.Flap blood perfusion was measured.One sample was taken randomly from each row.Morphological changes,apoptosis,receptor-interacting protein-1 (RIP-1) expression and caspase-3 activity were observed and detected.The measurements between the two groups were compared with the independentt-test,and aPvalue of <0.05 was considered statistically significant.Results:Compared to flaps in the CTL group,flaps in the Nec-1 group showed longer survival rates,better blood perfusion and less inflammatory infiltration.The total flap area considered to have survived was 70.88 ± 10.28% in the CTL group,whereas 80.56 ± 5.40% of the area was found to be living in the Nec-1 group (Nec-1 vs.CTL,t= –2.624,P<0.05).For some rows,there were significant differences in cell apoptosis between the two groups,the apoptosis index (AI) in rows '9 cm','7 cm','6 cm' and '5 cm' was significantly lower in the Nec-1 group than that in the CTL group (Nec-1 vs.CTL,P<0.05).RIP-1 expression was much lower in the Nec-1 group than that in the CTL group in rows '5 cm' to '9 cm' (Nec-1 vs.CTL,P<0.05).No significant differences in caspase-3 activity were found.Conclusion:According to the results,necroptosis was present in a rat abdominal ischaemia/reperfusion injury flap model. | Hao Uu Ming-Zi Zhang Yi-Fang Liu Xin-Hang Dong Yan Hao You-Bin Wang | 2019 | Chinese Medical Journal2019，，1： | 6 |
| 2 | Surgically induced astigmatism after superotemporal and superonasal clear corneal incisions in phacoemulsification显示文摘 | Ermis SS Inan UU Ozturk F | 2004 | J Cataract Refract Surg2004，30，6： | 1 |
| 3 | Transeatheter closure of Atrial septal defeet and patenth foramen ovale with ASDOS device (a multi-institutional European trial)显示文摘 | Sievert H Baltic UU Haysdof G et a1 | | 0，，： | 1 |
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| 5 | An extended VIKORmethod based on prospect theory for multiple attribute de-cision making under interval type-2 fuzzy environment显示文摘 | QIN J D UU X W PEDRYCZ W | 2015 | Knowledge-Based Systems2015，86，： | 1 |
| 6 | Does simplicity compromise accuracy in ACS risk prediction?A retrospective analysis of the TIMI and GRACE risk scores显示文摘 | Aragam KG Tamhane UU Kline-Rogers E | | 0，，11： | 1 |
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| 13 | Hot water epilepsy:seizure type,water temperature,EEG findings and treatment显示文摘 | Zeki G Ilker IH Hidir UU | | 0，，02： | 1 |
| 14 | Isolation and identi-fication of lactic acid bacteria from Tarag in Eastern InnerMongolia of China by 16S rRNA sequences and DGGE analy-sis显示文摘 | UU W J BAO Q Ht JIRIMUTU | 2012 | Microbiological Research2012，167，2： | 1 |
| 15 | Bacterial exopolysaccharides:functionality and prospects显示文摘 | Nwodo UU Green E Okoh AI | 2012 | Int J Mol Sci2012，13，14： | 1 |
| 16 | Overall evaluation of geotechnical hazard based on fuzzy set theory显示文摘 | VAN Uu Nguyen | 1985 | Soils and Foundations1985，25，4： | 1 |
| 17 | Minimum-entropy phase adjustment for ISAR显示文摘 | WangJ Uu X Zhou Z | 2005 | IEEE Proc-Radar Sonar Navigation2005，152，2： | 1 |
| 18 | Acta Pharmaceuti- ca显示文摘 | Li Jing W Xiao-Jian Uu Chang-Xiao | 2006 | Sinica2006，41，： | 1 |
| 19 | Multilayer neural-net robot controller with guaranteed tracking performance显示文摘 | LEWIS F L YESILDIREK A UU K | 1996 | IEEE Transactions on Neural Networks1996，7，2： | 1 |
| 20 | Fibrinogen angina and coronary heart disease in a Chinese population 显示文摘 | Lain TH Uu LJ Janus ED | 2000 | Atherosclerosis2000，149，： | 1 |
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