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| 1 | Irritable bowel syndrome and small intestinal bacterial overgrowth:Meaningful association or unnecessary hype显示文摘Irritable bowel syndrome(IBS)is a common condition characterized by abdominal pain or discomfort,bloating,and altered stool form and passage.Small intestinal bacterial overgrowth(SIBO)is a condition in which there is overgrowth of bacteria in small bowel in excess of 105colony forming units per milliliter on culture of the upper gut aspirate.Frequency of SIBO varied from 4%-78%among patients with IBS and from 1%-40%among controls.Higher frequency in some studies might be due to fallacious criteria[postlactulose breath-hydrogen rise 20 PPM above basal within 90 min(early-peak)].Glucose hydrogen breath test(GHBT)has a low sensitivity to diagnose SIBO.Hence,studies based on GHBT might have under-estimated frequency of SIBO.Therefore,it is important to analyze these studies carefully to evaluate whether the reported association between IBS and SIBO is over or under-projected.This review evaluates studies on association between SIBO and IBS,discordance between different studies,their strength and weakness including methodological issues and evidence on therapeutic manipulation of gut flora on symptoms of IBS. | Uday C Ghoshal Deepakshi Srivastava | 2014 | World Journal of Gastroenterology2014，20，10： | 29 |
| 2 | Pathogenesis of achalasia cardia显示文摘Achalasia cardia is one of the common causes of motor dysphagia.Though the disease was first described more than 300 years ago,exact pathogenesis of this condition still remains enigmatic.Pathophysiologically,achalasia cardia is caused by loss of inhibitory ganglion in the myenteric plexus of the esophagus.In the initial stage,degeneration of inhibitory nerves in the esophagus results in unopposed action of excitatory neurotransmitters such as acetylcholine,resulting in high amplitude non-peristaltic contractions(vigorous achalasia);progressive loss of cholinergic neurons over time results in dilation and low amplitude simultaneous contractions in the esophageal body(classic achalasia).Since the initial description,several studies have attempted to explore initiating agents that may cause the disease,such as viral infection,other environmental factors,autoimmunity,and genetic factors.Though Chagas disease,which mimics achalasia,is caused by an infective agent,available evidence suggests that infection may not be an independent cause of primary achalasia.A genetic basis for achalasia is supported by reports showing occurrence of disease in monozygotic twins,siblings and other first-degree relatives and occurrence in association with other genetic diseases such as Down's syndrome and Parkinson's disease.Polymorphisms in genes encoding for nitric oxide synthase,receptors for vasoactive intestinal peptide,interleukin 23 and the ALADIN gene have been reported.However,studies on larger numbers of patients and controls from different ethnic groups are needed before definite conclusions can be obtained.Currently,the disease is believed to be multi-factorial,with autoimmune mechanisms triggered by infection in a genetically predisposed individual leading to degeneration of inhibitory ganglia in the wall of the esophagus. | Uday C Ghoshal Sunil B Daschakraborty Renu Singh | 2012 | World Journal of Gastroenterology2012，18，24： | 20 |
| 3 | Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India显示文摘AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P < 0.001, odds ratio (OR) 8.20; 95% confidence interval (95% CI), 4.08-16.47] and PUD (77.4% vs 31.1%, P < 0.001; OR 8.04; 95% CI, 3.25-19.90). Risk of gastric adenocarcinoma was significantly higher in patients having C carrier with (OR 7.83; 95% CI 3.09-19.85) and without H pylori infection (OR 7.06; 95% CI, 2.61-19.09). Patients with C carrier and H pylori infection had significant risk for the development of PUD (P < 0.001; OR 5.65; 95% CI, 2.07-15.34). CONCLUSION: -765G > C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD. | Ashish Saxena Kashi Nath Prasad Uday Chand Ghoshal Monty Roshan Bhagat Narendra Krishnani Nuzhat Husain | 2008 | World Journal of Gastroenterology2008，14，10： | 18 |
| 4 | 热塑性复合材料在航空航天中的应用显示文摘热塑性复合材料在航空航天领域迅速发展,如航空和导弹防御中的应用。热塑性复合材料具有重量轻、高比模量和强度、设计自由度高、易加工和可回收的优点。本文介绍了伯明翰阿拉巴马大学(UAB)在航空航天用不连续或连续碳纤维热塑性复合材料最近的研究工作,包括电子产品外壳的复杂基板、配载门、罩片和结构承重构件。所使用的工艺包括挤压压缩、纤维注射、变截面板和真空成型,大大缩短了制备周期。 | Uday Vaidya 李进松 管佳明 | 2015 | 航空制造技术2015，58，14： | 18 |
| 5 | Reliability modeling of hydraulic system of drum shearer machine显示文摘 | SEYED HADI Hoseinie MOHAMMAD Ataie REZA Khalookakaei UDAY Kumar | 2011 | Journal of Coal Science & Engineering(China)2011，17，4： | 7 |
| 6 | Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma显示文摘Helicobacter pylori (H pylori ) etiologically 被连接了到胃的 cancer.H pylori 感染在象印度,孟加拉国,巴基斯坦,和泰国一样的少些发达的亚洲国家是更经常的并且比在更多的发达亚洲人国家喜欢日本和中国在早年龄被获得。然而,胃的癌症的频率在与那相比的印度,孟加拉国,巴基斯坦和在日本和中国的泰国是很低的。类似的谜作为与韦斯特相比从非洲被报导了。在印度,孟加拉国,巴基斯坦和泰国的成年人口的 H pylori 感染的 Seroprevalence 从 55% ~ 92% 变化。相反,在中国、日本的成年人的 H pylori 的 seroprevalence 分别地是 44% 和 55% 。在印度,孟加拉国,和泰国的胃的癌症的年度发生率是 10.6, 1.3, 7.1 每 100,000 张人口分别地;相反,那分别地每 100,000 张人口在中国和日本是 32-59 和 80-115。来自印度的几研究没能比控制与胃的癌症在病人显示出 H pylori 感染的高频率。可得到的证据没作为对这个谜的解释在 H pylori 紧张支持差别。尽管有 H pylori 的确定的病因学的角色,因为,状况在亚洲国家是有点神秘的在有感染的高频率的国家,有胃的癌症的更低的率。主人的基因组成和饮食、环境的因素力量解释这个谜。研究着急地被需要解决这个问题。 | Kartar Singh Uday C Ghoshal | 2006 | World Journal of Gastroenterology2006，12，9： | 5 |
| 7 | Noni(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats显示文摘Objective: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni(M. citrifolia) fruit juice(NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.Methods: Lymphocytes isolated from axillary and inguinal lymph nodes of young(3–4 months) and old(18–21 months) rats were treated in vitro with different concentrations(0.0001%, 0.01%, and 1%) of NFJ for a period of 24 h. In the in vivo study, old(16–17 months) male F344 rats were treated with 5 mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60 d. Concanavalin A(Con A)-induced lymphocyte proliferation, interleukin-2(IL-2)and interferon-γ(IFN-γ) production and expression of intracellular markers, such as phosphoextracellular signal-regulated kinase(p-ERK1/2), phospho-γ AMP response element-binding protein,phospho-protein kinase B(p-Akt), phospho-tyrosine hydroxylase(p-TH), phospho-nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α(p-IκB-α) and phospho-nuclear factor-κB(p-NF-κB p65 and p50) were examined in the lymphocytes of lymph nodes.Results: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-γ production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-κB p65 and p50.Conclusion: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. | Uday P.Pratap Hannah P.Priyanka Karthik R.Ramanathan Vishak Raman Lalgi Hima Srinivasan Thyagarajan | 2018 | Journal of Integrative Medicine2018，16，3： | 5 |
| 8 | Solid lipid nanoparticles for nose to brain delivery of haloperidol:in vitro drug release and pharmacokinetics evaluation显示文摘In the present study,haloperidol(HP)-loaded solid lipid nanoparticles(SLNs)were prepared to enhance the uptake of HP to brain via intranasal(i.n.)delivery.SLNs were prepared by a modified emulsification-diffusion technique and evaluated for particle size,zeta potential,drug entrapment efficiency,in vitro drug release,and stability.All parameters were found to be in an acceptable range.In vitro drug release was found to be 94.1674.78%after 24 h and was fitted to the Higuchi model with a very high correlation coefficient(R2¼0.9941).Pharmacokinetics studies were performed on albino Wistar rats and the concentration of HP in brain and blood was measured by high performance liquid chromatography.The brain/blood ratio at 0.5 h for HP-SLNs i.n.,HP sol.i.n.and HP sol.i.v.was 1.61,0.17 and 0.031,respectively,indicating direct nose-to-brain transport,bypassing the blood-brain barrier.The maximum concentration(Cmax)in brain achieved from i.n.administration of HP-SLNs(329.17720.89 ng/mL,Tmax 2 h)was significantly higher than that achieved after i.v.(76.9577.62 ng/mL,Tmax 1 h),and i.n.(90.1376.28 ng/mL,Tmax 2 h)administration of HP sol.The highest drug-targeting efficiency(2362.43%)and direct transport percentage(95.77%)was found with HP-SLNs as compared to the other formulations.Higher DTE(%)and DTP(%)suggest that HP-SLNs have better brain targeting efficiency as compared to other formulations. | Mohd Yasir Udai Vir Singh Sara | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 5 |
| 9 | Inflammatory bowel disease-related colorectal cancer:Past,present and future perspectives显示文摘Inflammatory bowel disease-related colorectal cancer(IBD-CRC)is one of the most serious complications of IBD contributing to significant mortality in this cohort of patients.IBD is often associated with diet and lifestyle-related gut microbial dysbiosis,the interaction of genetic and environmental factors,leading to chronic gut inflammation.According to the“common ground hypothesis”,microbial dysbiosis and intestinal barrier impairment are at the core of the chronic inflammatory process associated with IBD-CRC.Among the many underlying factors known to increase the risk of IBD-CRC,perhaps the most important factor is chronic persistent inflammation.The persistent inflammation in the colon results in increased proliferation of cells necessary for repair but this also increases the risk of dysplastic changes due to chromosomal and microsatellite instability.Multiple pathways have been identified,regulated by many positive and negative factors involved in the development of cancer,which in this case follows the‘inflammation-dysplasia-carcinoma’sequence.Strategies to lower this risk are extremely important to reduce morbidity and mortality due to IBD-CRC,among which colonoscopic surveillance is the most widely accepted and implemented modality,forming part of many national and international guidelines.However,the effectiveness of surveillance in IBD has been a topic of much debate in recent years for multiple reasons—cost-benefit to health systems,resource requirements,and also because of studies showing conflicting long-term data.Our review provides a comprehensive overview of past,present,and future perspectives of IBD-CRC.We explore and analyse evidence from studies over decades and current best practices followed globally.In the future directions section,we cover emerging novel endoscopic techniques and artificial intelligence that could play an important role in managing the risk of IBD-CRC. | Snehali Majumder Uday Nagesh Shivaji Rangarajan Kasturi Alben Sigamani Subrata Ghosh Marietta Iacucci | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 5 |
| 10 | 放射损伤对外源骨髓间充质干细胞迁徙定植的影响显示文摘【目的】研究机体中枢神经系统受放射损伤时骨髓间充质干细胞(MSCs)的迁徙定植特性的改变,从而为应用MSCs治疗中枢神经系统放射损伤提供理论和实验依据。【方法】用8周龄SD大鼠接受22GyX线照射制作枢神经系统放射损伤模型;从GFP鼠抽取骨髓,分离和扩增MSCs。中枢神经系统受放射损伤的SD大鼠4个月后予静脉输注GFP-MSCs。于移植后几个时间点取脑、骨髓、肝、脾等做冰冻切片,用双光子共聚焦红外脉冲激光显微镜检测GFP-MSCs。【结果】在最早24h内实验组和对照组的骨髓中检测到外源性GFP阳性细胞,至第7天后实验组骨髓中GFP阳性细胞显著多于对照组。脑内第1天未检测到外源性GFP阳性细胞,第4天后中枢神经系统受放射损伤的SD大鼠,脑组织检测到带绿色荧光的外源性GFP阳性细胞;而对照组脑内一直未检测到带绿色荧光的外源性MSCs。实验组和对照组脾脏在输注MSCs后第1天即检测到大量GFP阳性细胞,并持续存在,第21天实验组GFP阳性细胞较对照组减少。【结论】在放射损伤条件下外源性MSCs可透过血脑屏障到达脑组织,中枢神经系统放射损伤可诱导外源性MSCs向脑组织迁徙定植。 | 罗向阳 Mohi Rezvani 夏焱 岑丹阳 何展文 李栋方 Uday Tirlapur | 2008 | 中山大学学报(医学科学版)2008，29，5： | 4 |
| 11 | Role of Tumor Necrosis Factor-Alpha (C-863A) Polymorphism in Pathogenesis of Inflammatory Bowel Disease in Northern India显示文摘 | Dinesh Ahirwar Pravin Kesarwani Ranjana Singh Uday Ghoshal Rama Mittal | 2012 | Journal of Gastrointestinal Cancer2012，，2： | 3 |
| 12 | Reliability and maintainability analysis of electrical system of drum shearers显示文摘 | SEYED Hadi Hoseinie MOHAMMAD Ataei REZA Khalokakaie UDAY Kumar | 2011 | Journal of Coal Science & Engineering(China)2011，17，2： | 3 |
| 13 | The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A显示文摘Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation,adhesion,differentiation,and embryogenesis.The downstream effectors through which Rap1A mediates its diverse effects are largely unknown.Here we show that Rap1A,but not the related small G proteins Rap2 or Ras,binds the tumor suppressor Ras association domain family 1A(RASSF1A)in a manner that is regulated by phosphorylation of RASSF1A.Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior. | Sunil K.Verma Trivadi S.Ganesan Uday Kishore Peter J.Parker | 2011 | Protein & Cell2011，2，3： | 3 |
| 14 | Release rate kinetics of corrosion inhibitor loaded halloysite nanotube-based anticorrosion coatings on magnesium alloy AZ91D显示文摘Halloysite nanotubes were used as nanocontainers to hold corrosion inhibitors such as Ce^(3+)-Zr^(4+),2-mercaptobenzothiazole and 8-hydroxyquinoline in their lumen.An acid assisted etching of the nanotubes was carried out with a view to increase the lumen diameter and thereby,increase the amount of loading of the corrosion inhibitor.The morphology of as-received and etched halloysite nanotubes was ob-served using TEM analysis.The loading of corrosion inhibitors was confirmed using SEM-EDS and BET analysis.Polymeric microcapsules were used as capping agents for the ends of the loaded HNTs following which,they were dispersed into a hybrid sol-gel silica matrix.Dip coating method was used to generate coatings on AZ91D substrates followed by heat treatment at 130℃ for 1 h.The release rate kinetics of corrosion inhibitors from as-received and etched nanotubes was investigated in buffer solutions of 3.5 wt%NaCl at different pH.The release mechanism of corrosion inhibitors from the HNT lumen was validated using various semi-empirical models.Coatings were also evaluated for their corrosion protection ability using electrochemical techniques after exposure to 3.5 wt%NaCl solution for 120 h.Coatings generated using Ce^(3+)-Zr^(4+)loaded into as-received halloysite nanotubes have shown more effective corrosion protection when compared to other corrosion inhibitors after 120 h exposure to the corrosive medium. | Swapnil H.Adsul Uday D.Bagale Shirish H.Sonawane R.Subasri | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 15 | Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review显示文摘Irritable bowel syndrome(IBS) is a chronic gastrointestinal disorder, common in clinic and in the community. It has a significant impact on both society and patients' quality of life. The epidemiology, clinical presentation, and management of IBS may vary in different geographical regions due to differences in diet, gastrointestinal infection, socio-cultural and psychosocial factors, religious and illness beliefs, symptom perception and reporting. Although previous reviews and consensus reports on IBS in Asia have been published, Asia is quite diverse socio-demographically. In this context, India, Bangladesh and Malaysia share some similarities, including:(1) large proportion of the population living in rural areas;(2) rapid development and associated lifestyle changes in urban areas; and(3) dietary, cultural and religious practices. The present review explores the clinical and epidemiological data on IBS from these three major nations in South and South-East Asia. In-depth review of the literature revealed important differences between IBS in the East, as revealed by studies from these three countries, and the West; these include a predominantly rural profile, differences in bowel habit and symptom profile, raising concern with regards to diagnostic criteria and subtyping of IBS, higher dietary fiber consumption, frequent lactose malabsorption, parasitosis, and possible overlap between post-infectious IBS and tropical sprue. Moreover, the current perception on difference in prevalence of the disorder in these countries, as compared to the West, might be related to variation in survey methods. | M Masudur Rahman Sanjiv Mahadeva Uday C Ghoshal | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 16 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 17 | Emerging SOM technology for the green synthesis of metals from oxides显示文摘 | Uday B. Pal David E. Woolley George B. Kenney | 2001 | JOM2001，，10： | 2 |
| 18 | A rare case of langerhans cell histiocytosis of the gastrointestinal tract显示文摘Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized,bone marrow-derived langerhans cells and mature eosinophils.The clinical spectrum ranges from an acute,fulminant,disseminated disease called LettererSiwe disease to solitary or few,indolent and chronic lesions of the bone or other organs called eosinophilic granuloma.Involvement of the gastrointestinal tract is very rare in LCH.We present the case of a 53-yearold woman referred by her primary care physician for a screening colonoscopy.A single sessile polyp,measuring 4 mm in size,was found in the rectum.Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm.The nuclei within these cells had frequent grooves and were occasionally folded.Immunohistochemical staining was positive for CD1a which confirmed the diagnosis of LCH.On further workup,there was no evidence of involvement of any other organ.On follow up colonoscopy one year later,there was no evidence of disease recurrence.Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare.However,with the increas-ing rates of screening colonoscopy,more colonic polyps may be identified as LCH on histopathology.This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease. | Uday Shankar Monika Prasad Om P Chaurasia | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 19 | Deposition of atmospheric pollutant and their chemical characterization in snow pit profile at Dokriani Glacier,Central Himalaya显示文摘The uncertainty in assessing the numerous atmospheric pollutants transported via wind from arid and semi-arid regions is affecting the glacial ecosystem. In our study area due to the complexity of the system, a prominent seasonal difference noticed among major ions(Ca^(2+), Mg^(2+), SO_4^(2-), and NO_3^-). There is a need for understanding the ions cycling as a whole and the directionality of the feedback loops in the system. Therefore, we provide an appraisal of our current hypothesis for seasonal difference in major ion concentration from snow samples for two corresponding years(2013 and 2015) at Dokriani Glacier. A systematic study of chemical compositionsin the shallow snow pit from Dokriani Glacier was undertaken for the pre-monsoon season to understand the cycling of major ions from atmosphere to solute acquisition process. The intimating connections of ions cycling in snow and its temporal behavior was observed and analyzed through various statistical tests. Among major ions, the SO_4^(2-)has the highest concentration among anions on an average considered as 14.21% in 2013 and 29.46% in 2015. On the other side Ca^(2+) is the dominant cation contributing 28.22% in 2013 and 15.3% in 2015 on average. The average ratio of Na+/Cl-was higher in 2013 whereas lower in 2015. The backward trajectory analysis suggests the possible sources of the ions transported from Central Asia through the Western Disturbance(WD) as a prominent source of winter precipitation mainly in the Central Himalaya. Ionicconcentration of Ca^(2+) in cations was highly dominated while in anion SO_4^(2-)played the major role. Factor analysis and correlation matrix suggested that, the precipitation chemistry is mostly influenced by anthropogenic, crustal, and sea salt sources over the studied region. The elemental cycling through ocean, atmosphere and biosphere opens up new ways to understand the geochemical processes operating at the glacierized catchments of the Himalaya. Moreover, increasing the field-based studies in the coming decades would also have the certain advantage in overcoming the conceptual and computational geochemical modelling difficulties. | Shipika SUNDRIYAL Tanuj SHUKLA Lekhendra TRIPATHEE Dwarika Prashad DOBHAL Sameer Kumar TIWARI Uday BHAN | 2018 | Journal of Mountain Science2018，15，10： | 2 |
| 20 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
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