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| 1 | Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain显示文摘Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2′-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen Neu N, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2′-deoxyuridine-positive ? anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke. | Sun Ryu Seung-Hoon Lee Seung U.Kim Byung-Woo Yoon | 2016 | Neural Regeneration Research2016，11，2： | 22 |
| 2 | Brain Transplantation of Immortalized Human Neural Stem Cells Promotes Functional Recovery in Mouse Intracerebral Hemorrhage Stroke Model显示文摘 | Hong J.Lee Kwang S.Kim Eun J.Kim Hyun B.Choi Kwang H.Lee In H.Park YongKo Sang W.Jeong Seung U.Kim | 2009 | STEM CELLS2009，，： | 1 |
| 3 | Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model显示文摘 | KiryoWakabayashi AtsushiNagai Abdullah Md.Sheikh YuriShiota DashdemberelNarantuya TatsuzoWatanabe JunichiMasuda ShotaiKobayashi Seung U.Kim ShuheiYamaguchi | 2010 | J Neurosci Res2010，，5： | 1 |
| 4 | Influence of the prodrugs 5‐fluorocytosine and CPT‐11 on ovarian cancer cells using genetically engineered stem cells: tumor‐tropic potential and inhibition of ovarian cancer cell growth显示文摘 | Ki‐YonKim Seung U.Kim Peter C. K.Leung Eui‐BaeJeung Kyung‐ChulChoi | 2010 | Cancer Science2010，，4： | 1 |
| 5 | Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B显示文摘 | S. U.Kim Y. S.Seo J. Y.Cheong M. Y.Kim J. K.Kim S. H.Um S. W.Cho S. K.Paik K. S.Lee K.‐H.Han S. H.Ahn | 2010 | Alimentary Pharmacology & Therapeutics2010，，3： | 1 |
| 6 | Radial Pulse and Electrocardiography Modulation by Mild Thermal Stresses Applied to Feet: An Exploratory Study with Randomized, Crossover Design显示文摘Objective:To investigate the changes in radial pulse induced by thermal stresses(TSs).Methods:Sixty subjects were enrolled.Using an open-label,2x2 crossover randomization design,both feet of each subject were immersed in 15%:water for cold stress(CS)and in 40 X:water for heat stress(HS)for 5 min each.Radial pulse,respiration and electrocardiogram(ECG)signals were recorded before,during and immediately after the TSs.Results:The an alysis of heart rate variability revealed that CS in creased the low-freque ncy(LF)and high-frequency(HF)components(P<0.05)and that HS reduced the LF and HF components(P<0.01).Both TSs reduced the normalized LF,increased the normalized HF,and reduced the LF/HF ratio.The differences in the ECG signals were more dominant during the TS sessions,but those in the radial pulse signals became more domi nant immediately after the TS sessi ons.CS decreased the pulse depth(P<0.01)and in creased the radial augme ntation in dex(P<0.1),and HS in creased the pulse pressure(P<0.1)and sube ndocardial viability ratio(P<0.01).There were no significant differences in pulse rate during the three time sequences of each TS.The respiration rate was increased(P<0.1),and the pulse rate per respiration(P/R ratio)was significantly decreased(P<0.05)with CS.The HF region(10-30 Hz)of the pulse spectral density was suppressed during both TSs.Conclusions:CS induced vasoconstriction and sympathetic reactions,and HS induced vasodilation and parasympathetic reacti ons.Based on defi nitions used in pulse diag no sis,we made the novel discoveries that the pulse became slower(decreased P/R ratio),more floating and tenser under CS and that the HF region of the spectral power decreased significantly under both TSs. | Jang-Han Bae Boncho Ku Young Ju Jeon Hyunho Kim Jihye Kim Haebeom Lee Jong Yeol Kim Jaeuk U.Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，4： | 0 |
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