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| 1 | Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults显示文摘BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the world.Multiple factors influence the development of obesity.Some research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional status.Report of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to increase.Although the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy homeostasis.GM affect body weight,especially obesity.Probiotics that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and Staphylococcus.The strain of L.plantarum Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing L.plantarum Dad-13.The consumption of probiotic L.plantarum Dad-13 powder decreased E.coli and non-E.coli coliform bacteria in school-aged children in Indonesia.L.plantarum is a dominant bacterium in the average Indonesian’s GM.For this reason,this bacterium is probably a more suitable probiotic for Indonesians.AIM To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder L.plantarum Dad-13(2×109 CFU/gram/sachet)for 90 d.The study was a randomized,double-blind,placebocontrolled study.The volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowel movements,fecal quality(consistency and color),any medications received,and any symptom of discomfort,such as diarrhea,constipation,vomiting,gassing,sensation of illness,etc.Fecal samples and the subjects’diaries were collected on the morning of day 10+1,which was marked as the end of the baseline period and the start of the ingestion period.During the ingestion period(from day 11 to day 101),several parameters to measure and analyze the results included body weight and height(once a month),the lipid profile,GM analysis using MiSeq,short-chain fatty acid(SCFA)analysis using gas chromatography,and the measurement of fecal pH using a pH meter.RESULTS The consumption of indigenous probiotic powder L.plantarum Dad-13 caused the average body weight and BMI of the probiotic group to decrease from 84.54±17.64 kg to 83.14±14.71 kg and 33.10±6.15 kg/m2 to 32.57±5.01 kg/m2,respectively.No significant reduction of body weight and BMI in the placebo group was observed.An analysis of the microbiota showed that the number of Bacteroidetes,specifically Prevotella,increased significantly,while that of Firmicutes significantly decreased.No significant change in lipid profile in both groups was found.Also,no significant change in SCFAs(e.g.,butyrate,propionate,acetic acid)and pH level was found after the consumption of the probiotic.CONCLUSION No significant differences in pH before and after ingestion were observed in both the probiotic and placebo groups as well as in the lipid profile of both cholesterol and triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL),and the LDL/HDL ratio.In addition,no significant changes in the concentration of SCFAs(e.g.,acetic acid,propionate,and butyrate)were found after consumption.Interestingly,a significant decrease in body weight and BMI(P<0.05)was determined in the treatment group.An analysis of GM shows that L.plantarum Dad-13 caused the Firmicutes population to decrease and the Bacteroidetes population(especially Prevotella)to increase. | Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka Putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie Agung Endro Nugroho Tyas Utami | 2021 | World Journal of Gastroenterology2021，27，1： | 6 |
| 2 | Gut microbiota profile in healthy Indonesians显示文摘BACKGROUND Recently, gut microbiota has been associated with various diseases other than intestinal disease. Thus, there has been rapid growth in the study of gut microbiota. Considering the numerous factors influencing gut microbiota such as age, diet, etc., area-based research is required. Indonesia has numerous different tribes and each of these tribes have different lifestyles. Hence, it is expected that each tribe has a specific gut microbiota. A deeper insight into the composition of gut microbiota can be used to determine the condition of gut microbiota in Indonesians and to consider which treatment may be suitable and effective to improve health status.AIM To investigate the gut microbiota of Indonesian subjects represented by Javanese and Balinese tribes by analyzing fecal samples.METHODS Fecal samples were collected from a total of 80 individuals with 20 in each of the young groups ranging from 25-45 years and the elderly group aged 70 years or more from two different regions, Yogyakarta and Bali. Fecal sample collection was performed at the end of the assessment period(day 14 ± 1 d) during which time the subjects were not allowed to consume probiotic or antibiotic products.The quantification of various Clostridium subgroups, Lactobacillus subgroups,Enterococcus, Streptococcus, Staphylococcus, Bacteroides fragilis group and Prevotella,Bifidobacterium and Atopobium cluster, Enterobacteriaceae and Pseudomonas was performed using the Yakult intestinal flora-scan(YIF-SCAN).RESULTS The bacterial population in younger subjects' feces was higher than that in the elderly population, with a total of approximately 10.0 – 10.6 log10 bacterial cells/g feces. The most abundant bacteria in all groups were Clostridium, followed by Prevotella, Atopobium, Bifidobacterium and Bacteroides. In the elderly, an increase in Enterobacteriaceae, Coliform and Escherichia coli was found. In terms of bacterial counts in Yogyakarta, total bacteria, Clostridium coccoides(C. coccoides) group,Bifidobacterium, Prevotella, Lactobacillus plantarum subgroup, and Streptococcus were significantly higher(P < 0.05) in younger than elderly subjects, while the Lactobacillus gasseri subgroup, Lactobacillus casei subgroup, and Lactobacillus reuteri subgroup counts were significantly lower(P < 0.05) in younger subjects. In Balinese subjects, total bacteria, C. coccoides group, Clostridium leptum subgroup,Bacteroides fragilis group, and Prevotella were significantly higher(P < 0.05) in younger compared to elderly individuals, while the Lactobacillus ruminis subgroup, and Enterobacteriaceae were significantly lower(P < 0.05) in younger subjects. The results also revealed that, besides the C. coccoides group and Clostridium leptum group being the most abundant gut microbiota in both Yogyakarta and Balinese people, the latter was indicated by a higher Clostridium perfringens count, which was almost 10 times that of Yogyakarta subjects. This may be a response to different lifestyles in the different tribes; however, this phenomenon requires further extensive study.CONCLUSION Bacterial populations were higher in younger than in elderly subjects. Most abundant bacterial groups were Clostridium, Prevotella, Atopobium, Bifidobacterium,and Bacteroides. The level of Clostridium perfringens in Yogyakarta subjects was lower than that in Balinese subjects. | Endang Sutriswati Rahayu Tyas Utami Mariyatun Mariyatun Pratama Nur Hasan Rafli Zulfa Kamil Ryan Haryo Setyawan Fathyah Hanum Pamungkaningtyas IskANDar Azmy Harahap Devin Varian Wiryohanjoyo Putrika Citta Pramesi Muhammad Nur Cahyanto I Nengah Sujaya Mohammad Juffrie | 2019 | World Journal of Gastroenterology2019，25，12： | 6 |
| 3 | 基于油藏特征的完井方法显示文摘通过优化完井,无需动用管柱,可提高措施效率、开采多个油气藏及多层非均质砂岩油藏,从而控制开发成本并提高采收率。印尼苏门答腊Jabung区块开发井钻遇三类典型油气藏:气顶油环油气藏、多油气藏及多砂岩非均质油藏。根据各类油气藏的特点,采用针对性的完井方法,优化的完井方法利用常规完井技术和井下工具实现单井一次完井,无需复杂的再完井措施,可同时或接替生产多个油气藏。此外,针对非均质多砂岩特点,应用可控的分层注水技术,可提高油藏采收率。上述完井方法已成功应用于不同类型油藏中,为油气水分布复杂的小断块油田开发过程中控制操作成本、提高开发井的整体效益提供了借鉴。 | 吕晓光 张学文 刘永喜 Bradford W Sincock Budi Tyas Utomo | 2008 | 石油勘探与开发2008，35，4： | 5 |
| 4 | Effect of cross-sectional surface area on bond stI'engths between resin and dentin 显示文摘 | Phrukkanon S Burrow MF Tyas MJ | 1998 | Dent Mater1998，14，2： | 1 |
| 5 | The influence of cross - sectional shape and surface area on the microtensile bond test 显示文摘 | Phrukkanon S Burrow MF Tyas MJ | | Dent Mater0，14，3： | 1 |
| 6 | Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada显示文摘 | Tyas S Manfreda J Strain L | 2001 | Int J Epidemiol2001，30，： | 1 |
| 7 | Effects of condition- ers on microshear bond strength to enamel after carba- mide peroxide bleaching and/or casein phosphopeptide- amorphous calcium phosphate (CPP-ACP) treatment显示文摘 | Adebayo OA Burrow MF Tyas MJ | 2007 | J Dent2007，35，11： | 1 |
| 8 | Apical dentin permeability and microleakage associated with root end resection and retrograde filling显示文摘 | Gilheany PA Figdor D Tyas MJ | | 0，，01： | 1 |
| 9 | Cracked tooth syndrome: diagnosis, treatment and correlation between symptoms and post - extraction findings显示文摘 | Ehrmann EH Tyas MT | 1990 | Aust Dent J1990，35，2： | 1 |
| 10 | Psychosocial factors related to adolescent smoking:a critical review of the literature显示文摘 | Tyas SL Pederson LL | 1998 | Tobacco Control1998，7，： | 1 |
| 11 | Effect of cross-sectional surface area on bond strengths between resin and dentin显示文摘 | Phrukkanon S Burrow MF Tyas MJ | | 0，，02： | 1 |
| 12 | The influence of crosssectional shape and surface area on the microtensile bond test显示文摘 | Phrukkanon S Burrow MF Tyas MJ | | 0，，03： | 1 |
| 13 | The repair potential of resin composite materials显示文摘 | Maneenut C Sakoolnamarka R Tyas MJ | 2011 | Dent Mater2011，27，2： | 1 |
| 14 | Strain patterns in cervical enamel of teeth subjected to occlusal loading显示文摘 | Palmnara D Palam ara JE Tyas MJ | 2000 | Dent Mater2000，16，6： | 1 |
| 15 | Cracked tooth syndrom;diagnosis,treatment and correlation between symptoms and post extraction显示文摘 | Ehrman EH Tyas MT | 1990 | Findings Dent J1990，35，2： | 1 |
| 16 | Nanoleakage patterns of four dentin bonding systems显示文摘 | Li H Burrow MF Tyas MJ | 2000 | Dent Mater2000，16，1： | 1 |
| 17 | Minimal Intervention Dentistry-A Review显示文摘 | Tyas Martin J Anusavice Kenneth J Frencken J | 2000 | Internation Dental Journal2000，50，： | 1 |
| 18 | Cracked tooth syndrome : diagnosis, treat- ment and correlation between symptoms and post-extraction find- ings显示文摘 | Ehrmann EH Tyas MT | 1990 | Aust Dent J1990，35，2： | 1 |
| 19 | Practical plastic layout optimization of trusses incorporating stability considerations 显示文摘 | Tyas A Gilbert M Pritchard T | 2006 | Computers & Structures2006，84，34： | 1 |
| 20 | Intracranial atherosclerosisas a contributing factor to A|zheimer's disease dementia显示文摘 | Roher AE Tyas SL Maarouf CL | 2011 | Alzhe- imers Dement2011，7，： | 1 |
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