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| 1 | White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment显示文摘Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk factor.Methods We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRINT MIND)trial.The primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from enrolment.The primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH volumes.The secondary predictor was a binary WMH progression threshold(≥1.4 mL vs<1.4 mL).Results Among the 433 included patients,33(7.6%)developed dementia/MCI.There were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients with<1.4 mL WMH progression(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MIND,WMH progression over 48 months was associated with the development of probable dementia or MCI. | Adam de Havenon Kevin N Sheth Sharon D Yeatts Tanya N Turan Shyam Prabhakaran | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 2 | The prevention of pain from injection of roeuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil显示文摘 | Turan A Memis D Karamanlioglu B | 2003 | Anaesth Intensive Care2003，31，3： | 1 |
| 3 | The prevention of pain from injection of propofol by dexmedetomidine and com- parison with lidocaine 显示文摘 | Turan A Memis D Kaya G | 2005 | Can J Anaesth2005，52，5： | 1 |
| 4 | Production of human milk fat analogue containing docosahexaenoic and araehidonie acids 显示文摘 | Turan D Sahin Yesil Ubuk N Akoh C C | 2012 | Journal of Agricultural and Food Chemistry2012，60，17： | 1 |
| 5 | Application of low pressure NF membme for the recovery and reuse of dairy in- dustry effluents显示文摘 | Koyuncu I Turan M Topacik D | 2000 | Water Sci Techn2000，41，1： | 1 |
| 6 | Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption显示文摘 | Karamanlioglu B Turan A Memis D | | 0，，10： | 1 |
| 7 | The prevention of pain from iniection of propofol by dexmedetomidine and comparison with lidocaine显示文摘 | TURAN A MEMIS D KAYA G | 2005 | Can J Anaesth2005，52，5： | 1 |
| 8 | Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption显示文摘 | Karamanlioglu B Turan A Memis D | 2005 | Can J Anaesthesia2005，52，10： | 1 |
| 9 | Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation显示文摘 | Memis D Turan A Karamanlioglu B | 2006 | Eur J Anaesthesiol2006，23，8： | 1 |
| 10 | Analgesic effect of gabapentin after spinal surgery 显示文摘 | Turan A Karamanlioglu B Memis D | 2004 | Anesthesiology2004，100，4： | 1 |
| 11 | The prevention of pain from injection of propofol by dexmedetomidine and comparison with li-docaine显示文摘 | Turan A Memis D Kaya G | | 0，，5： | 1 |
| 12 | Adding dexmedeto- midine to lidocaine for intravenous regional anesthesia显示文摘 | Memis D Turan A Karamanlioglu B | 2004 | Anesth Analg2004，98，3： | 1 |
| 13 | Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption显示文摘 | Karamanlioglu B Turan A Memis D | 2005 | Can J Anaesth2005，52，10： | 1 |
| 14 | The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl显示文摘 | Memis D Turan A Karamanlioglu B | 2002 | Anesh Analg2002，94，6： | 1 |
| 15 | The prevention of pain from injection of rocuronium by ondansetron,lidocaine,tramadol,and fentanyl显示文摘 | Memi D Turan A Karamanlio lu B Süt N Pamuk Cu Z | 2002 | Anesth Analg2002，94，： | 1 |
| 16 | Effect of preoperative oral use of erythtomycin and nizatidine on gastric pH and volume显示文摘 | MEMIS D TURAN A KARAMANLIONLU B | 2002 | Anaesth Interns Care2002，30，4： | 1 |
| 17 | Addiction of dexmedetomidine to lidicaine for intravenous regional an- esthesia显示文摘 | Memics D Turan A Karamanlioglu B | 2004 | Anesth Analg2004，98，： | 1 |
| 18 | The prevention of pain from injection of rocuronium by magnesium sulphate,lignocaine,sodium bicarbonate and alfentani 显示文摘 | Turan A Memis D Karamanlioglu B | 2003 | Anaesth Intesive Care2003，31，3： | 1 |
| 19 | Intravenous regional anesthesia using prilocaine and neostigmine显示文摘 | Turan A Karamanlioglu B Memis D | 2002 | Anesth Analg2002，95，： | 1 |
| 20 | Susceptibility to seasickness显示文摘 | Bos J E Damala D Lewis C Ganguly A Turan O | 2007 | Ergonomics2007，50，： | 1 |
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