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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | A topological and func- tional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal anti- bodies 显示文摘 | Heinz F Berger R Tuma W | 1983 | Virology1983，126，2： | 1 |
| 3 | PCR for HBV,HCV and HIV-1 experiences and first results from a routine screening programme in a large blood transfusion service显示文摘 | Schottstedt V Tuma W Bunger G | 1998 | Biologicals1998，26，： | 1 |
| 4 | A novel cysteine-rich secretedprotein associated with pulmonary infiammation, defines a new gene family显示文摘 | Holcomb IN Kabakoff RC Chan B Baker TW Gurney A Henzel W Nelson C Lowman HB Wright BD Skelton NJ Frantz GD Tumas DB Peale FV Jr Shelton DL Hebert CC FIZZI | | 0，，： | 1 |
| 5 | Asymmetric catalytic hydrogenation reactions in supercritical carbon dioxide显示文摘 | Burk M J Feng S G Tumas W | 1995 | J Am Chem Soc1995，117，： | 1 |
| 6 | Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization显示文摘 | Tumas DB Chart B Werther W | 2001 | J Allergy Clin Immunol2001，107，： | 1 |
| 7 | Who gets student aid? Variations in access to aid 显示文摘 | Grubb W N & Tuma J | 1991 | Review of Higher Education1991，，03： | 1 |
| 8 | Odor volatiles associated with microflora in damp ventilated and non-ventilated bin-stored bulk wheat显示文摘 | Tuma D Sinha R N Muir W E | 1989 | International Journal of Food Microbiology1989，8，2： | 1 |
| 9 | 显示文摘 | Powell K R Mccleskey T M Tumas W | 2001 | Ind Eng Chem Res2001，40，5： | 1 |
| 10 | Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization显示文摘 | Tumas DB Chan B Werther W | 2001 | J Allergy Clin Immunol2001，107，6： | 1 |
| 11 | Hydrogen:An overview显示文摘 | LUBITZ W TUMAS B | 2007 | Chem Rev2007，107，： | 1 |
| 12 | Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization显示文摘 | Tumas DB Chan B Werther W | 2001 | J Allergy and Clinical Immunol2001，107，6： | 1 |
| 13 | Uranyl Photochemistry with Alkenes: Distinguishing between H-Atom Abstraction and Electron Transfer显示文摘 | Mccleskey T M Burns C J Tumas W | 1999 | Inorg Chem1999，38，： | 1 |
| 14 | Asymmetric catalytic hydrogenation reactors in supercritical carbon dioxide显示文摘 | BUBK M J FENC S CBOSS M F TUMAS W J | 1995 | J Am Chem Soc1995，117，： | 1 |
| 15 | Hydrogen:An overview显示文摘 | Lubitz W Tumas W | 2007 | Chemical Reviews2007，107，10： | 1 |
| 16 | Odor volatiles associated with microflora in damp ventilated and nonventilated bin -stored bulk wheat显示文摘 | Tuma D Sinha R N Muir W E | 1989 | International Journal of Food Microbiology1989，8，： | 1 |
| 17 | PCR for HBV, HCV and HIV-Ⅰ experiences and first results form a routine screening programme in a large blood transfusion 显示文摘 | Schottsted V Tuma W Bunger G | 1998 | Service Biological1998，26，2： | 1 |
| 18 | Odor volatiles associated with microflora in damp ventilated and nonventilated bin -stored bulk wheat 显示文摘 | Tuma D Sinha R N Muir W E | 1989 | International Journal of Food Microbiology1989，8，： | 1 |
| 19 | New chiral 1,1'- bis(phospholano) ferrocene ligands for asymmetric catalysis 显示文摘 | Burk M J Feng S G Tumas W | 1995 | Journal of the Americal Chemical Society1995，117，： | 1 |
| 20 | Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization显示文摘 | Tumas DB Chan B Werther W | 2001 | J Allergy Clin Immunol2001，107，6： | 1 |
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