|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 2 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 3 | Influence of marbling and animal age on factors associated with beef quality显示文摘 | Tuma H J Henrickson R L Stephens D F | 1962 | Animal Science1962，21，11： | 1 |
| 4 | Solubility of CO2 in the ionic liquid 显示文摘 | Perez-Salado Kamps A Tuma D Xia J | 2003 | Journal of Chemical & Engineering Data2003，48，3： | 1 |
| 5 | The chemistry and biological effects of malondisldehyde-acetaldehyde adducts 显示文摘 | Thiele GM Worrall S Tuma D | 2001 | Alcohol Clin Exp Red2001，，25： | 1 |
| 6 | Percutaneous nephrolithotomy: variables that influence hemorrhage 显示文摘 | Tuma B Nazli D Demiryoguran S | 2007 | Urology2007，69，4： | 1 |
| 7 | Safety,pharmacokinetics and pharmacodynamics of GS-9620,an oral Toll-like receptor 7 agonist显示文摘 | Lopatin U Wolfgang G Tumas D Frey CR Ohmstede C Hesselgesser J Kearney B Moorehead L Subramanian G M McHutchison J G | 2013 | Antivir Ther2013，18，3： | 1 |
| 8 | Ethanol feeding inhibits the activity of hepatic N5 methyltetrahydrofolate-homocysteine methyltransferase in the rat显示文摘 | BARAK A J BECKENHAUER H C TUMA D J | 1985 | IRCS Med Sci1985，13，8： | 1 |
| 9 | Effects of prolonged ethanol feeding in methionine metabolism in rat liver显示文摘 | BARAK A J BECKENHAUER H C TUMA D J | 1987 | Biochem Cell Biol1987，65，3： | 1 |
| 10 | Solubility of CO in the ionic liquid 显示文摘 | Kumelan J Perez'Salado Kamps A Tuma D | 2005 | Fluid Phase Equil2005，，： | 1 |
| 11 | Solubility of CO2 in the ionic liquid 显示文摘 | Kamps A Tuma D Xia J Z et ol | 2003 | J Chem Eng Data2003，48，3： | 1 |
| 12 | Dangerous Byproducts of Alcohol Breakdown Focus on Adducts显示文摘 | TUMA D J CASEY C A | 2003 | Alcohol Res Health2003，27，4： | 1 |
| 13 | Microtubules are more stable and more highly acetylated in ethanol-treated he- patic cells显示文摘 | Kannarkat G T Tuma D J Tuma P L | 2006 | J Hepatol2006，44，5： | 1 |
| 14 | Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration 显示文摘 | Tuma DJ Thiele GM Xu D | 1996 | Hepatology1996，23，4： | 1 |
| 15 | Solubility of CO2 in the ionic liquids and 显示文摘 | Kumelan J Perez-Salado Kamps A Tuma D | 2006 | J Chem Eng Data2006，51，5： | 1 |
| 16 | Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis显示文摘 | BENNETT R G HEIMANN D G TUMA D J | 2009 | Ann N Y Acad Sci2009，1160，1： | 1 |
| 17 | Solubility of CO2 in the Ionic Liquid IBmiml PF61 显示文摘 | Kamps A P S Tuma D Xia J | 2003 | J Chem EngData2003，48，3： | 1 |
| 18 | The chemistry and biological effects of malondialdehyde-acetaldehyde adducts 显示文摘 | Thiele GM Worrall S Tuma D J | 2001 | Alcohol Clin Exp Res2001，25，5： | 1 |
| 19 | Recent advances in alcohol- induced adduct formation显示文摘 | Freeman T L Tuma D J Thiele G M | 2005 | Alcohol Clin Exp Res2005，29，： | 1 |
| 20 | Solubility of H2 in the ionic liquid 显示文摘 | K umelan J Perez-Salado Kamps A Tuma D | 2006 | J ChemEngData2006，51，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员