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| 1 | Precision medicine in gastric cancer显示文摘Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic alterations.GC represents the second leading cause of cancer-related deaths worldwide.Its onset is subtle,and the majority of patients are diagnosed once the cancer is already advanced.In recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular characteristics.Thanks to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic methods.Among the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this end.After phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic GC.However,the heterogeneity of this neoplasia makes the practical application of such approaches difficult.Unfortunately,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in prognosis.Survival continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate cancers.Although several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially changed.Currently,surgical resection with adjuvant or neoadjuvant radiotherapy and chemotherapy are the most effective treatments for this disease.Future research should not underestimate the heterogeneity of GC when developing diagnostic and therapeutic strategies aimed toward improving patient survival. | Patrizia Bonelli Antonella Borrelli Franca Maria Tuccillo Lucrezia Silvestro Raffaele Palaia Franco Maria Buonaguro | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 8 |
| 2 | Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases显示文摘 | Carmela Loguercio Alessandro Federico Concetta Tuccillo Fulvia Terracciano Mauro Valeriano D?Auria Claudio De Simone Camillo Del Vecchio Blanco | 2005 | Journal of Clinical Gastroenterology2005，，6： | 2 |
| 3 | Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases显示文摘 | Carmela Loguercio Alessandro Federico Concetta Tuccillo Fulvia Terracciano Mauro Valeriano D?Auria Claudio De Simone Camillo Del Vecchio Blanco | 2005 | Journal of Clinical Gastroenterology2005，，6： | 2 |
| 4 | Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic li- ver diseases显示文摘 | Loguercio C Federico A Tuccillo C et ol | 2005 | J Clin Gastroenterol2005，39，6： | 1 |
| 5 | Beneficial effects of a probiotie VSL 3 on parameters of liver dysfunction in chronic liver diseases显示文摘 | Loguercio C Federico A Tuccillo C | 2005 | J Clin Gastroenterol2005，39，6： | 1 |
| 6 | Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo显示文摘 | Graziani G D'Argenio G Tuccillo C | 2005 | Gut2005，54，2： | 1 |
| 7 | Chronic inflammation and oxidative stress in human carcinogenesis显示文摘 | Federico A Morgillo F Tuccillo C | 2007 | Int J Cancer2007，121，11： | 1 |
| 8 | Size fractionation of metals in runoff from residential and highway storm sewers显示文摘 | TUCCILLO M E | | 0，，1： | 1 |
| 9 | Beneficial ef- fects of a probiotic VSL#3 on parameters of liver dys- function in chronic liver diseases显示文摘 | Loguercio C Federico A Tuccillo C | 2005 | J Clin Gastroenterol2005，39，6： | 1 |
| 10 | A spatio- temporal view of historical growth in Phoenix,Arizona,USA显示文摘 | Kane ~Tuccillo J York A M | 2014 | Landscape and Urban Planning2014，121，： | 1 |
| 11 | A VAS-numerical model impact study using the Gal-Chen's variational approach显示文摘 | Aune R M Tuccillo J J Uccellini L W | | 0，，： | 1 |
| 12 | The effect of a new symbiotic formulation on plasma levels and peripheral blood mononuclear cell expression of some pro - inlammatory cyto- kines in patients with ulcerative colitis: a pilot study 显示文摘 | Federico A Tuccillo C Grossi E | 2009 | Eur Rev Med Pharmacol Sci2009，13，4： | 1 |
| 13 | Size fractionation of metals in runoff from residential and highway storm sewers 显示文摘 | Tuccillo M E | 2006 | Science of the Total Environment2006，355，13： | 1 |
| 14 | Treatment of polychlorinated biphenyls in two surface soils using catalyzed H 2 O 2 propagations显示文摘 | Mushtaque Ahmad Michelle A. Simon Alex Sherrin Mary Ellen Tuccillo Jeffrey L. Ullman Amy L. Teel Richard J. Watts | 2011 | Chemosphere2011，，7： | 1 |
| 15 | Antitumor activity of ZD6474, a vascular endothelial growth factor -2 and epidermal growth factor receptor small molecule tyrosine kinase inhibitor, in combination with SC - 236, a cyclooxygenase - 2 inhibitor 显示文摘 | Tuccillo C Romano M Troiani T | 2005 | Clin Cancer Res2005，11，： | 1 |
| 16 | 显示文摘 | Zarrilli R Tuccillo C Santangelo M | 1999 | Am J Gastroenterol1999，94，11： | 1 |
| 17 | Progression of natural attenuation processes at a crude oil spill site(Ⅱ):Controls on spatial distribution of microbial populations 显示文摘 | Bekins B A Cozzarelli I M Godsy E M Warren E Essaid H I Tuccillo M E | 2002 | Journal of Contaminant Hydrology2002，53，： | 1 |
| 18 | Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases显示文摘 | Carmela Loguercio Alessandro Federico Concetta Tuccillo Fulvia Terracciano Mauro Valeriano D?Auria Claudio De Simone Camillo Del Vecchio Blanco | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 19 | Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases显示文摘 | Loguercio C Federico A Tuccillo C | 2005 | J Clin Gastroenterol2005，39，6： | 1 |
| 20 | Chronic inilamma- tion oxidative stress in human carcinogenesis 显示文摘 | Federico A Morgillo F Tuccillo C | 2007 | Int J Cancer2007，121，11： | 1 |
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