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| 1 | Treatment of young patients with lupus nephritis using calcineurin inhibitors显示文摘Recent advances in the management of lupus nephritis,together with earlier renal biopsy and selective use of aggressive immunosuppressive therapy,have contributed to a favorable outcome in children and adolescents with systemic lupus erythematosus(SLE).Nevertheless,we believe that a more effective and less toxic treatment is needed to attain an optimal control of the activity of lupus nephritis.Recent published papers and our experiences regarding treatment of young patients with lupus nephritis using calcineurin inhibitors are reviewed.Although it has been reported that intermittent monthly pulses of intravenous cyclophosphamide(IVCY)are effective for preserving renal function in adult patients,CPA is a potent immunosuppressive agent that induces severe toxicity,including myelo-and gonadal toxicity,and increases the risk of secondary malignancy.Thus,treatment for controlling lupus nephritis activity,especially in children and adolescents,remains challenging.Cyclosporine A(Cs A)and tacrolimus(Tac)are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells,thereby inhibiting thetranscription of the early activation genes of interleukin(IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-α,IL-1βand IL-6.Therefore,both drugs,which we believe may be less cytotoxic,are attractive therapeutic options for young patients with lupus nephritis.Recently,a multidrug regimen of prednisolone(PDN),Tac,and mycophenolate mofetile(MMF)has been found effective and relatively safe in adult lupus nephritis.Since the mechanisms of action of MMF and Tac are probably complementary,multidrug therapy for lupus nephritis may be useful.We propose as an alternative to IVCY,a multidrug therapy with mizoribine,which acts very similarly to MMF,and Tac,which has a different mode of action,combined with PDN for pediatric-onset lupus nephritis.We also believe that a multidrug therapy including Cs A and Tac may be an attractive option for young patients with SLE and lupus | Hiroshi Tanaka Kazushi Tsuruga Tomomi Aizawa-Yashiro Shojiro Watanabe Tadaatsu Imaizumi | 2012 | World Journal of Nephrology2012，1，6： | 8 |
| 2 | Significance of functional hepatic resection rate calculated using 3D CT/^(99m)Tc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging显示文摘AIM: To evaluate the usefulness of the functional hepatic resection rate(FHRR) calculated using 3D computed tomography(CT)/^(99m)Tc-galactosyl-human serum albumin(GSA) single-photon emission computed tomography(SPECT) fusion imaging for surgical decision making. METHODS: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and March 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynamic multidetector CT and ^(99m)Tc-GSA scintigraphy. We compared the parenchymal hepatic resection rate(PHRR) with the FHRR, which was defined as the resection volume counts per total liver volume counts on 3D CT/^(99m)Tc-GSA SPECT fusion images.RESULTS: In total, 50 patients underwent bisectionectomy and seven underwent trisectionectomy.Biliary reconstruction was performed in 15 patients, including hepatopancreatoduodenectomy in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16(P < 0.0001). The ratio of FHRR to PHRR for patients with preoperative therapies(transcatheter arterial chemoembolization, radiation, radiofrequency ablation, etc.), large tumors with a volume of > 1000 m L, and/or macroscopic vascular invasion was significantly smaller than that for patients without these factors(0.73 ± 0.19 vs 0.82 ± 0.18, P < 0.05). Postoperative hyperbilirubinemia was observed in six patients. Major morbidities(Clavien-Dindo grade ≥ 3) occurred in 17 patients(29.8%). There was no case of surgeryrelated death.CONCLUSION: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepant owing to insufficient hepatic inflow and congestion in patients with preoperative therapies, macroscopic vascular invasion, and/or a tumor volume of > 1000 m L. | Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Shingo Shimada Kenji Wakayama Tatsuya Orimo Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketomi | 2016 | World Journal of Gastroenterology2016，22，17： | 6 |
| 3 | Neonatal Exposure to Sevoflurane Causes Significant Suppression of Hippocampal Long-Term Potentiation in Postgrowth Rats显示文摘 | Rui Kato Kaori Tachibana Naoki Nishimoto Toshikazu Hashimoto Yosuke Uchida Ryoko Ito Kenkichi Tsuruga Koichi Takita Yuji Morimoto | 2013 | Anesthesia & Analgesia2013，，6： | 2 |
| 4 | Management of young patientswith lupus nephritis using tacrolimus administered as a single dailydose显示文摘 | Tanaka H Oki E Tsuruga K | 2009 | Clin Nephrol2009，72，6： | 1 |
| 5 | Bleomycin treatment for cystic hygroma in children显示文摘 | Yura J Hashimoto T Tsuruga N Shibata K | 1977 | Nippon Geka Hokan1977，46，： | 1 |
| 6 | Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis:implication of its mitochondrial abnormality显示文摘 | Ijiri K Tsuruga H Sakakima H | 2005 | Ann Rheum Dis2005，64，6： | 1 |
| 7 | Pore size of porous hydroxyapatite as the cell-substratum controls BMP-in- duced osteogenesis显示文摘 | Tsuruga E Takita H Itoh H | 1997 | J Biochem1997，121，2： | 1 |
| 8 | insulin response patterns contribute to different perinatal risks in gestationaI diabetes 显示文摘 | Yamada H Hirayama KE Tsuruga R | 2001 | Gynecol ObstetInvest2001，51，2： | 1 |
| 9 | Bleomycin treatment for cystic hygroma in children显示文摘 | Yura J Hashimoto T Tsuruga N | 1977 | Nihon Geka Hokan1977，46，5： | 1 |
| 10 | Bleomycin treatment for cystic hy- groma in children显示文摘 | Yura J Hashimoto T Tsuruga N | 1977 | Arch JPN Chir1977，46，4： | 1 |
| 11 | Cytoskeleton disruption accelerates caspase-3activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis 显示文摘 | Yamazak Y Tsuruga M Zhou D | 2000 | Experimental Cell Research2000，259，： | 1 |
| 12 | Bleomycin treatment for cystic hygroma in children 显示文摘 | Yura J Hashimoto T Tsuruga N | 1977 | Nihon Geka Hokan1977，46，5： | 1 |
| 13 | Porr size of porous hydroxyapatie as the cell-substratum controls BMP-induced osteogenesis显示文摘 | Tsuruga E Takita H Itoh H | 1997 | J Biochem1997，121，： | 1 |
| 14 | Insulin response patterns contribute to different perinatal risks in gestational diabetes显示文摘 | Yamada H Hirayama Kato E Tsuruga R | 2001 | Gynecol Obstet2001，，2： | 1 |
| 15 | Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis显示文摘 | Yamazaki Y Tsuruga M Zhou D | 2000 | Exp Cell Res2000，259，1： | 1 |
| 16 | Amelioration of type Ⅱ diabetes in db/db mice by continuous low-dose-rate gamma irradiation显示文摘 | Tsuruga M Taki K Ishii G | 2007 | Radiat Res2007，167，5： | 1 |
| 17 | Effects of post-irradiation annealing on the transformation behavior of Ti-Ni alloys显示文摘 | Kimura A Tsuruga H Morimura T | 1993 | Mater Trans JIM1993，34，： | 1 |
| 18 | Imbalance towards Th1pathway predominance in purpura nephritis with proteinuria显示文摘 | Tsuruga K Watanabe S Oki E | 2011 | PediatrNephrol2011，26，12： | 1 |
| 19 | Management of young patients with lupus nephritis using tacrolimus administered as a single daily dose显示文摘 | Tanaka H Oki E Tsuruga K | | 0，，06： | 1 |
| 20 | Induction of fibulin-5 gene is regulated by tropoelastin gene, and correlated with tropoelastin accumulation in vitro显示文摘 | Tsuruga E Yajima T Irie K | 2004 | Int J Biochem Cell Biol2004，36，： | 1 |
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