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| 1 | Effect of prolonged cryptorchidism on germ cell apoptosisand testicular sperm count显示文摘Aim:To evaluate the long term effect of experimental cryptorchidism on germ cell apoptotic rate and testicular sperm content in adult rats.Methods:Bilateral cryptorchidism was created in 40 adult male Sprague-Dawley rats by surgically manipulating the testes into the abdominal cavity and closing the internal inguinal ring.The rats were sacrificed and the testes removed 6 hours and 2,4,7,21,28 and 56 days after cryptorchidism.Germ cell apoptosis was quantified by means of TUNEL assay and apoptosis was confirmed using transmission electron microscopy.Results:The rate of apoptosis peaked at 4 days of cryptorchidism and then progressively declined to a nadir at 14 days of cryptorchidism.At 56 days of cryptorchidism,the germinal epithelium was largely depleted by the apoptotic process and only a few mature sperm were seen within the testis.At this point,a few tubules were seen to be repopulating with primary spermatocytes and the level of germ cell apoptosis began to increase marginally.Testicular sperm count (TSC) began to decline rapidly at day 7 of cryptorchidism.Only a few mature sperm were found in the testes of rats following 56 days of cryptorchidism.Multinucleated giant cells (MGC) were most numerous within the seminiferous tubules at day 4.At day 7,35% of MGCs were TUNEL positive.At all subsequent time points,however,MGCs fail to stain positive for apoptosis.This resumption of increased apoptosis coincided with the appearance of a population of primary spermatocytes in some seminiferous tubules.Moreover,there was not a corresponding increase in the number of mature sperm after 56 days of cryptorchidism.Conclusion:The decline in germ cell apoptosis after 4 days of cryptorchidism can be attributed to be the result of an overall depletion of germ cells.It appears that after a prolonged cryptorchidism (56 days),there is a limited resumption of spermatogenesis presumably as a result of a decrease in the maturing germ cells undergoing programmed cell death.(Asian JAndrol2004 Mar;6:47-51) | Albaha Barqawi Herald Trummer Randall Meacham | 2004 | Asian Journal of Andrology2004，6，1： | 7 |
| 2 | Incresse in biliary permeability subsequent to intrahepatic cholestssis by estradiol valerate in the rats显示文摘 | Trummer E Krell H | 1988 | Gastroenterology1988，93，： | 1 |
| 3 | Color-codedduplex ultrasound in pre-occlusive stenoses of the internalcarotid artery 显示文摘 | Hetzel A Eckenweber B Trummer B | 1993 | Ultraschall Med1993，14，5： | 1 |
| 4 | Right hemispheric frontal lesions as a cause for anorexia nervosa report of three cases显示文摘 | Trummer M Eustacchio S Unger F | | 0，，： | 1 |
| 5 | Endoscopic percutaneous transforaminal treatment for herniated lumbar discs显示文摘 | Eustacchio S Flaschka G Trummer M | 2002 | Acta Neurochir(Wien)2002，144，10： | 1 |
| 6 | Effect of storage temperature on sperm cryopreservation显示文摘 | Trummer H Tucker K Young C | 1998 | Fertil Steril1998，70，： | 1 |
| 7 | Next-Generation Proximity and Position Sensors 显示文摘 | Trummer G Kurzhals C Gehring R | 2004 | Sensors ( Peterborough NH )2004，21，3： | 1 |
| 8 | Efficacy and safety of alow-dose combined oral contraceptive containing drospirenone 3mg and ethinylestradiol 20 meg in a 24/4 -day regimen 显示文摘 | Hemddi L Marr J Trummer D | 2009 | Contraception2009，80，1： | 1 |
| 9 | Suppression of ovar- ian activity with a drospirenone-containing oral contraceptive in a 24/4 regimen显示文摘 | Klipping C Duijkers I Trummer D | 2008 | Contraception2008，78，1： | 1 |
| 10 | Etiologic and causative factors in perianal dermatitis: results of a prospective study in 126 patients显示文摘 | Birger Kr?nke Michaela Trummer Eva Brabek Peter Komericki Theo Dieter Turek Werner Aberer | 2006 | Wiener klinische Wochenschrift (-)2006，，3： | 1 |
| 11 | Early endoscopy in systemic sclerosis without gastrointestinal symptoms显示文摘 | Rene Thonhofer Cornelia Siegel Markus Trummer Winfried Graninger | 2012 | Rheumatology International2012，，1： | 1 |
| 12 | Etiologic and caus- ative factors in perianal dermatitis: results of a prospective study in 126 patients 显示文摘 | Kranke B Trummer M Brabek E | 2006 | Wien Kiln Wochenschr2006，118，34： | 1 |
| 13 | Addition of in-vitro generated endothelial microparticles to von- Willebrand plasma improves primary and secondary hemostasis显示文摘 | Trummer A Werwitzke S Wermes C | 2014 | Thromb Res2014，133，44： | 1 |
| 14 | Developmentof a nonlabeled immunosensor for the herbicide trifluralin via optical waveguide lightmode spectroscopic detection显示文摘 | Székács A Trummer N Adányi N | 2003 | Analytica Chimica Acta2003，487，： | 1 |
| 15 | Allelic Deter- minants of Vitamin D Insufficiency, Bone Mineral Density, and Bor Fractures显示文摘 | Trummer O Schwetz V Walter - Finell D | 2012 | J Clin Endocrinol Metab2012，97，7： | 1 |
| 16 | Intracranial aneurysms :a review of endovaseular and surgical treatment in 248 patients显示文摘 | Leber KA Klein GE Trummer M | 1998 | Minim Invasive Neurosurg1998，41，2： | 1 |
| 17 | Intracranial aneurysms: a review of endovascular and surgical treatment in 248 patients显示文摘 | Leber KA Klein GE Trummer M | 1998 | Minim Invasive Neurosurg1998，41，： | 1 |
| 18 | Vitamin D-associated poly- morphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome 显示文摘 | Wehr E Trummer O Giuliani A | 2011 | Eur J Endocrinol2011，164，5： | 1 |
| 19 | Depth of Interaction Resolution of LuAP and LYSO Crystals显示文摘 | Trummer J Auffray E Leeoq P | 2009 | Nuclear Instruments and Methods in Physics Research A2009，599，23： | 1 |
| 20 | Etiologic and causative factors in perianal dermatitis results of a prospective study in 126 patients显示文摘 | Kranke B Trummer M Brabek E | 2006 | Wien Klin Wochenschr2006，，118： | 1 |
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