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| 1 | PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer显示文摘Background:Programmed cell death ligand-1(PD-L1)and ligand-2(PD-L2)interaction with programmed cell death protein-1(PD-1)represent an immune-inhibiting checkpoint mediating immune evasion and is,accordingly,an important target for blockade-based immunotherapy in cancer.In non-small-cell lung cancer(NSCLC),improved understanding of PD-1 checkpoint blockade-responsive biology and identification of biomarkers for prediction of a clinical response to immunotherapy is warranted.Thus,in the present study,we systematically described PD-L1 and PD-L2 expression correlated genes in NSCLC.Methods:We performed comparative retrospective analyses to identify PD-L1 and PD-L2 mRNA expression corre-lated genes in NSCLC.For this,we examined available datasets from the cancer cell line encyclopedia(CCLE)project lung non-small-cell(Lung_NSC)and the cancer genome atlas(TCGA)projects lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC).Results:Analysis of the CCLE dataset Lung_NSC identified expression correlation between PD-L1 and PD-L2.Moreo-ver,we identified expression correlation between 489 genes and PD-L1,191 genes and PD-L2,and 111 genes for both.PD-L1 and PD-L2 also expression correlated in TCGA datasets LUAD and LUSC.In LUAD,we identified expression corre-lation between 257 genes and PD-L1,914 genes and PD-L2,and 211 genes for both.In LUSC,we identified expression correlation between 26 genes and PD-L1,326 genes and PD-L2,and 13 genes for both.Only a few genes expression correlated with PD-L1 and PD-L2 across the CCLE and TCGA datasets.Expression of Interferon signaling-involved genes converged in particular with the expression correlated genes for PD-L1 in Lung_NSC,for PD-L2 in LUSC,and for both PD-L1 and PD-L2 in LUAD.In LUSC,PD-L1,and to a lesser extent PD-L2,expression correlated with chromosome 9p24 localized genes,indicating a chromosome 9p24 topologically associated domain as an important driver of in particu-lar LUSC PD-L1 expression.Expression correlation analyses of the PD-L1 and PD-L2 receptors programmed cell death protein-1(PD-1),Cluster of differentiation 80(CD80),and Repulsive guidance molecule B(RGMB)showed that PD-1 and CD80 expression correlated with both PD-L1 and PD-L2 in LUAD.CD80 expression correlated with PD-L2 in LUSC.Conclusions:We present gene signatures associated with PD-L1 and PD-L2 mRNA expression in NSCLC which could possess importance in relation to understand PD-1 checkpoint blockade-responsive biology and development of gene signature based biomarkers for predicting clinical responses to immunotherapy. | Trine Vilsbøll Larsen Dianna Hussmann Anders Lade Nielsen | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Sudden cardiac death caused by myocarditis in persons aged 1-49 years:a nationwide study of 14 294 deaths in Denmark显示文摘Myocarditis is associated with an increased risk of sudden cardiac death (SCD) in the young.However,Information on nationwide burden of SCD caused by myocarditis (SCD-myocarditis) is sparse.For this study all deaths among persons in Denmark aged 1-35years in 2000-2009 and 36-49years in 2007-2009 (27.1 million person-years) were induded.Autopsy reports,death certificates,discharge summaries,and nationwide registries were used to identify all cases of SCD-myocarditis.In the 10-year study period,there were 14294 deaths,of which we identified 1 363 (10%) SCD.Among autopsied SCD (n=753,55%),cause of death was myocarditis in 42 (6%) cases corresponding to an SCD-myocarditis incidence of 0.16 (95%CI: 0.11-0.21) per 100000 person-years.Males had significantly higher incidence rates of SCD-myocarditis compared to females with an incidence rate ratio of 2.2 (95%CI:1.1-4.1).Myocarditis was not registered as cause of death In any of the non-autopsied SCD (n=610,45%).In conclusion,after nationwide unselected Inclusion of 14294 deaths,we found that 6% of all autopsied SCD was caused by myocarditis.No cases of SCD-myocarditis were reported in the non-autopsied SCD,which could reflect underdiagnosing of myocarditis in non-autopsied SCD.Furthermore,our data suggest a female protection towards SCDmyocarditis. | Thomas Hadberg Lynge Trine Skov Nielsen Bo Gregers Winkel Jacob Tfelt-Hansen Jytte Banner | 2019 | Forensic Sciences Research2019，4，3： | 3 |
| 3 | Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research. | Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 4 | Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage显示文摘一个高精子 DNA 破碎索引(DFI ) 与减少的富饶被联系。DFI 被在反应的氧种类和抗氧化剂之间的平衡影响。在 melatonin,一种抗氧化剂和免费激进的 scavenger 的一个 circannual 变化,能因此影响精液质量和富饶。在主要 melatonin 代谢物,尿 6-sulfatoxymelatonin (aMT6s ) ,和 DFI 之间的协会在 110 个奥斯陆人(北极圈的南方) 和 86 个 Tromsoe 人(北极圈的北方) 被分析。二精液分析,夏天和冬季,和四件尿样品(早 / 晚的夏天;早 / 晚的冬季) ,被分析。在在尿和 DFI 的 aMT6s 之间的协会用关联分析和线性回归以一种代表性、纵的方式被描绘。不管季节和地点,在 aMT6s 和 DFI 之间的重要关联都没被观察。(早冬季早的夏天) 为在变化之间的协会的关联系数随着时间的过去在 aMT6s 和 DFI 为全部的队:rho =− 0.08 (P = 0.322 ) ,为奥斯陆队:rho =− 0.07 (P = 0.485 ) ,并且为 Tromsoe 队:rho =− 0.14 (P = 0.273 ) 分别地。类似的结果被看是否比较迟了的冬季和迟了的夏天。为有 DFI 在下面并且在中部的价值(10%) 上面的人在 aMT6s 和 DFI 随着时间的过去在变化之间没有任何统计上重要的关联分别地。在 melatonin 排泄的季节的变化似乎不在 DFI 上有任何影响。 | Gunilla Maim Trine B Haugen Lars Rylander Aleksander Giwercman | 2017 | Asian Journal of Andrology2017，19，1： | 2 |
| 5 | Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein显示文摘 | Martin RJakobsen Trine HMogensen S #x000F8 ren RPaludan | 2013 | Cell Research2013，23，3： | 2 |
| 6 | Acute effects of righl ventricular apical pacing on left ventricublr synchrony and mechanics 显示文摘 | Delgado V Tops LF Trines SA el al | 2009 | Circ Arrhythmia Electrophysiol2009，2，： | 1 |
| 7 | Risk factors and time delay associated with cardiac device infections: Leiden device registry显示文摘 | Lekkerkerker JC van Nieuwkoop C Trines SA | 2009 | Heart2009，95，9： | 1 |
| 8 | Plasminogen activator inhibitor-1 increases the expression of VEGF in human glioma cells显示文摘 | Hjortland GO Trine L Stig S | 2004 | Exp Cell Res2004，294，1： | 1 |
| 9 | Application of fungal substrate from commercial mushroom production-Pleuorotus ostreatus-for bioremediation of creosote contaminated soil显示文摘 | Trine Eggen | 1999 | International Biodeterioration & Biodegradation1999，44，： | 1 |
| 10 | Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin显示文摘 | Raymond Lo Trine Celius Agnes L Forgacs | 2011 | Toxicol Appl Pharm2011，257，： | 1 |
| 11 | Development of a simple in- vial liquid-phase mieroextraetion device for drug analysis compatible with capillary gas chromatography, capillary eleetrophoresis and high- performance liquid chromatography显示文摘 | Rasmussen Knut Einar Pedersen - BjergaardS Mette Krogh Hege Grefslie Ugland Trine GrCnhang | 2000 | Chromatography A2000，873，： | 1 |
| 12 | Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis显示文摘 | Trine Olsen Rasmus Goll Cui Guang-lin | 2007 | Scandinavian Journal of Gastroenterology2007，42，11： | 1 |
| 13 | Speciation of CA and Zn in contaminated soils assessed by DGT- DTES and WHAM/Model VI in relation to uptake by spinach and ryegass显示文摘 | SGEIR R PEDER L TRINE A S | 2006 | Chemosphere2006，62，： | 1 |
| 14 | Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis显示文摘 | Renathe Rismo Trine Olsen Guanglin Cui Ingrid Christiansen Jon Florholmen Rasmus Goll | 2012 | Scandinavian Journal of Gastroenterology2012，，5： | 1 |
| 15 | C - reaction protein,early forecast of independent element , increased neck's atherosclerosis rate 显示文摘 | Trine M Helle AS Vibeke EH | 2000 | Circulation2000，104，1： | 1 |
| 16 | High performance metal-supported solid oxide fuel cells with Gd-doped ceria barrier layers显示文摘 | Trine Klemens Jimmi Nielsen Peter Blennow | | 0，，： | 1 |
| 17 | Effect of comprehensive cardiac rehabilitation after heart valve surgery (CopenHeartVR): study protocol for a randomised clinical tria显示文摘 | Kirstine Laerum Sibilitz Selina Kikkenborg Berg Tina Birgitte Hansen Signe Stelling Risom Trine Bernholdt Rasmussen Christian Hassager Lars K?ber Daniel Steinbrfichel Christian Gluud Per Winkel Lau Caspar Thygesen Jane Lindschou Hansen Jean Paul Schmid Viviane Conraads Barbara Christina Brocki Ann-Dorthe Zwisler | 2013 | Trials2013，14，： | 1 |
| 18 | A Fast Fixed-Point Algorithm for Independent Component Analysis显示文摘 | Aapo Hyv/trine Erkki Oja | 1997 | Neural Compu- tation1997，12，3： | 1 |
| 19 | C -Reactive Protein, dietary n- 3 fatty acids and the exent of coronary artery disease 显示文摘 | Trine M Helle AS Vibeke EH | 2001 | Am J Cardio12001，88，10： | 1 |
| 20 | Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium显示文摘 | De Z S Trines S A Krams R | 2000 | Br J Pharmacol2000，129，： | 1 |
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