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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Computer notes Precise:Software for prediction of cis-acting regulatory elements显示文摘 | BERLOO R V FIERS M | 2005 | J Heredity2005，，： | 1 |
| 3 | Time-dependent effects of intermittent hydrostatic pressure on aeticular chondrocyte type II collagen and aggrecan mRNA expression显示文摘 | SMITH R L LIN J TRINDADE M C | 2000 | J Reha bil Res Dev2000，37，2： | 1 |
| 4 | Bioremediationof a weathered and a recently oil-contaminated soils from Brazil:acomparison study显示文摘 | Trindade P V O Sobral L G Rizzo A C L | 2005 | Chemosphere2005，58，4： | 1 |
| 5 | Effects of neonatal hypoxia/ischemia on ganglioside expression in the rat hippocampus显示文摘 | Trindade VM Daniotti JL Raimondi L | 2001 | Neurochem Res2001，26，6： | 1 |
| 6 | Suppor-ted ionic liquid silica nanoparticles(SILnPs)as an efficient andrecyclable heterogeneous catalyst for the dehydration of fruc-tose to 5-hydroxymethylfurfural显示文摘 | Sidhpuria K B Daniel-da-Silva A L Trindade T | 2011 | Green Chem2011，13，2： | 1 |
| 7 | Differences in sensitivity to UVC, UVB and UVA radiation of a multidrug-resistant cell line overexpressing P-glycoprotein显示文摘 | Trindade G S Capella L S Affonso M | 1999 | Photochem Photobiol1999，69，6： | 1 |
| 8 | Structural characterization of novel chitin-binding lectins from the genus Artocarpus and their antifungal activity 显示文摘 | Trindade M B Lopes J L Soares-Costa A | 2006 | BBA-Gen Subjects2006，1764，： | 1 |
| 9 | Numerical model of electromagnetic stirring for continuous casting billets显示文摘 | Vilela A C F | 2002 | IEEE Transactions on Magnetics2002，38，6： | 1 |
| 10 | Photody- namic therapy in endodontics: a literature review 显示文摘 | Trindade AC De Figueiredo JA Steier L | 2015 | Photomed Laser Surg2015，33，3： | 1 |
| 11 | A potato tuber-expressed mRNA with homology to steroid dehydrogenases affects gibberellin levels and plant development显示文摘 | Bachem C W B Horvath B Trindade L | 2001 | The Plant Journal2001，25，6： | 1 |
| 12 | Numerical model of electromagnetic stirring for continuous casting billets 显示文摘 | Trindade L B Vilela A C F Filho A F F | 2002 | IEEE Transactions on Magnetics2002，38，6： | 1 |
| 13 | Nursing workloads and Working conditions:integrative review 显示文摘 | Schmoeller R Trindade Lde L Neis MB | 2011 | Rev Gaucha En- ferm2011，32，2： | 1 |
| 14 | A potato tuberexpressed mRNA with homology to steroid dehydrogenases affects gibberellin levels and plant development显示文摘 | Bachem C W B Horvath B Trindade L | 2001 | The Plant Journal2001，25，6： | 1 |
| 15 | Growth regula- tion and other secondary effects of herbicides 显示文摘 | Velini E D Trindade M L B Barberis L R M | 2010 | Weed Sci- ence2010，58，： | 1 |
| 16 | Production of bioavailable flavonoid glucosides in fruit juices and green tea by use of fungal α-L-rhamnosidases显示文摘 | GONZALEZ-BARRIO R TRINDADE L M MANZANARES P | 2004 | J Agr Food Chem2004，52，20： | 1 |
| 17 | Evidence of caffeine adsorption on a low-carbon steel surface in ethanol显示文摘 | da Trindade L G Gonalves R S | 2009 | Corrosion Science2009，，51： | 1 |
| 18 | Differences in sensitivity to UVC,UVB and UVA radiation of a multidrug-resistant cell line overexpressing P-glycoprotein显示文摘 | Trindade G S Capella M A Capella L S | 1999 | Photochem Photobiol1999，69，6： | 1 |
| 19 | Differential expression of the costimulatory molecules CD86,CD28,CD152 and PD-1 correlates with the host-parasite outcome in leprosy显示文摘 | Palermo Mde L Trindade MA Duarte AJ | 2012 | Memórias do Instituto Oswaldo Cruz2012，，1： | 1 |
| 20 | Plasma surface modification of polyethylene显示文摘 | Drnovská H Lapǒíková B BarrosTimmons A M Trindade T Zembala M Lapǒík L Jr | 2003 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2003，222，： | 1 |
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