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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Orally administered rapamycin does not modify rat aortic vascular tone显示文摘 | Nero Mde M Di Marco GS Casarini DE | 2007 | J Cardiovasc Pharmacol2007，49，2： | 1 |
| 3 | Inhibition of LPS-responses by synthetic peptides derived from LBP associates with the ability of the peptides to block LBP-LPS interactions显示文摘 | Arana Mde J Vallespi MG Chinea G | 2003 | J Endotoxin Res2003，9，5： | 1 |
| 4 | Treatment by Splenectomy of a Portal Vein Aneurysm in Hepatosplenic Schistosomiasis显示文摘 | Mucenic M Rocha Md Mde S Laudanna AA | 2002 | Rev Inst Med Trop Sao Paulo2002，44，5： | 1 |
| 5 | Paradoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress response显示文摘 | Galvao Mde O Sinigaglia-Coimbra R Kawakami S E | 2009 | Psychoneuroendocrinology2009，34，8： | 1 |
| 6 | Widity of microporous polysaccharide hemispheres as a hemostatic agent in hepatic injuries: all experimental study in rats显示文摘 | Biondo-Simees Mde L Petrauskas R Dobrowolski AG | 2007 | Acta Cir Bras2007，221，： | 1 |
| 7 | New formula to objectively evaluate skeletal maturation using lateral cephalometric radiographs显示文摘 | Caldas Mde P Ambrosano GM Haiter Neto F | 2007 | Braz Oral Res2007，21，4： | 1 |
| 8 | Supernumerary teeth vary depending on gender显示文摘 | Kuchler EC Costa AG Costa Mde C | 2011 | Braz Oral Res2011，25，1： | 1 |
| 9 | Psychosocial adaptation and quality of life among Brazilian patients with different hematological malignancies显示文摘 | Santos FR Kozasa EH Chauffaille Mde L et a1 | | 0，，51： | 1 |
| 10 | Time course of aquaporin expression after transient focal cerebral ischemia in mice 显示文摘 | Ribeiro Mde C Hirt L Bogousslavsky J | 2006 | J Neurosci Res2006，83，7： | 1 |
| 11 | The effect of microstructure and environment on fatigue crack growth in 7049 alloy at negative stress ratios显示文摘 | Fonte Mda Romeiro F Freitas Mde Stanzl-Tschegg S E Tchegg E K Vasudevan A K | 2003 | Int J Fatigue2003，25，： | 1 |
| 12 | Use of diet, nutritional supplements and exercise in HIV-infected patients receiving combination antiretroviral therapies: a systematic review 显示文摘 | Leyes P Martinez E Forga Mde T | 2008 | Antivir Ther2008，13，2： | 1 |
| 13 | Detection of epithelial apoptosis in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis显示文摘 | Leal RF Ayrizono Mde L Milanski M | 2010 | J Transl Med2010，8，11： | 1 |
| 14 | Hemodynamic changes in lipid emulsion therapy (SMOFlipid) for bupivacaine toxicity in swines 显示文摘 | Melo Mde S Bonfim MR Dreyer E | 2012 | Acta Cir Bras2012，27，4： | 1 |
| 15 | Bioactive peptides derived from milk proteins显示文摘 | Torres-Llanez Mde J Vallejo-Cordoba B Gonzalez-Cordova AF | 2005 | Arch LatinoamNutr2005，55，2： | 1 |
| 16 | Cesarean scar ectopic pregnancy:a case report显示文摘 | Arruda Mde S de Camargo Junior HS | 2008 | Rev Bras Ginecol Obstet2008，30，10： | 1 |
| 17 | Multilocus se quence typing method for identification and genotypic classification of pathogenic Leptospira species 显示文摘 | Ahmed N Devi SM Valverde Mde L | 2006 | Annals of Clinical Microbiology and Antimicrobials2006，5，： | 1 |
| 18 | Intraoperative uhrasonography for presumed brain metastases : a case series study 显示文摘 | Picarelli H Oliveira Mde L Bor-Seng-shu E | 2012 | Arq Neuropsiquiatr2012，70，10： | 1 |
| 19 | DLL4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth 显示文摘 | Segarra M Williams CK Sierra Mde L | 2008 | Blood2008，112，5： | 1 |
| 20 | Prefabrication of bone by use of a vascularized periosteal flap and bone morphogenetic protein显示文摘 | Vogelin MDE Jones NF Lieberman JR | 2002 | Plast Reconstr Surg2002，109，1： | 1 |
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