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| 1 | Interleukin-7 Receptor Signaling Network:An Integrated Systems Perspective显示文摘Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor,the IL-7 receptor (IL-7R),activates multiple pathways that regulate lymphocyte survival,glucose uptake,proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells,including the use of shared receptor components,signaling crosstalk,shared interaction domains,feedback loops,integrated gene regulation,multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology. | Megan J. Palmer Vinay S. Mahajan Lily C. Trajman Darrell J. Irvine Douglas A.Lauffenburger Jianzhu Chen | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 2 | Adverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis infection: a randomized trial显示文摘 | Menzies D Long R Trajman A | 2008 | Ann Intern Med2008，149，10： | 1 |
| 3 | Administrative measures for preventing Mycobacterium tuberculosis infection among healtheare workers in a teaching hospital in Rio de Janeiro, Brazil 显示文摘 | da Costa P A Trajman A Mello F C | 2009 | J Hosp Infect2009，72，1： | 1 |
| 4 | Pleural fluid ADA, IgA-ELISA and PCR sensitivities for the diag- nosis of pleural tuberculosis 显示文摘 | TRAJMAN A KAISERMANN C LUIZ R R | 2007 | Scand J Clin Lab Invest2007，67，8： | 1 |
| 5 | Novel tests for diagnosing tuberculous pleural effusion:what works and what does not显示文摘 | Trajman A Pai M Dheda K | | 0，，05： | 1 |
| 6 | Interferon-gamma release as- says versus tuberculin skin testing for the diagnosis of latent tu berculosis infection: an overview of the evidence显示文摘 | Trajman A Steffen RE Menzies D | 2013 | Pulm Med2013，2013，60： | 1 |
| 7 | Pteural fluid ADA,IgA-ELISA and PCR sensitivities for the diagnosis of pleural tuberculosis显示文摘 | Trajman A Kaisermann C Luiz RR | 2007 | Seand J Clin Lab Invest2007，67，8： | 1 |
| 8 | Pleural fluid ADA, IgA - ELISA and PCR sensitivities for the diagnosis of pleural tuberculosis 显示文摘 | Trajman A Kaisermann C Luiz RR | 2007 | Cline Lab invest2007，67，8： | 1 |
| 9 | Added value of QuantiFERON TB-Gold in-Tube for detecting latent tuberculosis infection among persons living with HIV/AIDS显示文摘 | SOUZA JM EVANGELISTA MDO S TRAJMAN A | 2014 | Biomed Resint2014，，： | 1 |
| 10 | Novel tests for diagnosing tuberculous pleural effusion: what works and what does not? 显示文摘 | Trajman A Pai M Dheda K | 2008 | Eur Respir J2008，31，5： | 1 |
| 11 | Novel tests for diagnosing tuberculous pleural effusion:what works and what does not显示文摘 | Trajman A Pai M Dheda K | 2008 | Eur Respir J2008，31，5： | 1 |
| 12 | Interferon-gamma release as-says versus tuberculin skin testing for the diagnosis of latent tu-berculosis infection:an overview of the evidence显示文摘 | Trajman A Steffen RE Menzies D | 2013 | Pulm Med2013，20，60： | 1 |
| 13 | Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection:An Overview of the Evidence显示文摘 | Trajman A Steffen RE Menzies D | 2013 | Pulmonary Medicine2013，2013，60： | 1 |
| 14 | Knowledge about STD/AIDS and sexual behavior among high school students in Rio de Janeiro Brazil显示文摘 | Trajman A Belo M T Teixeira E G | 2010 | Cad Saude Publica2010，，19： | 1 |
| 15 | Pleural fluid ADA, IgA-ELISA, and PCR sensitivities for the diagnosis of pleural tu- berculosis 显示文摘 | Trajman A Kaisermann C Luiz RR | 2007 | Scand J Lab Clin Invest2007，67，8： | 1 |
| 16 | McNemar chi2 test revisited:comparing sensitivity and specificity of diagnostic examinations显示文摘 | TRAJMAN A LUIZ R R | 2008 | Scand J Clin Lab Invest2008，68，1： | 1 |
| 17 | Administrative measures for preventing Mycobacterium tuberculosis infection among healthcare workers in a teaching hospital in Rio de Janeiro,Brazil显示文摘 | da Costa PA Trajman A Mello FC | | 0，，01： | 1 |
| 18 | Interferon -Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection:An Overview of the Evidence显示文摘 | Trajman A Steffen RE Menzies D | 2013 | Pulm Med2013，2013，60： | 1 |
| 19 | McNemar &khgr;<sup>2</sup> test revisited: comparing sensitivity and specificity of diagnostic examinations显示文摘 | A. Trajman R. R. Luiz | 2008 | Scandinavian Journal of Clinical & Laboratory Investigation2008，，1： | 1 |
| 20 | Novel tests for diagnosing tu- berculous pleura1 effusion: what works and what does not显示文摘 | Trajman A Pal M Dheda K | 2008 | Eu- ropean Respiratory Journal2008，31，5： | 1 |
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