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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Dental and periodontal phenotype in sclerostin knockout mice显示文摘Sclerostin is a Wnt signalling antagonist that controls bone metabolism.Sclerostin is expressed by osteocytes and cementocytes;however,its role in the formation of dental structures remains unclear.Here,we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography(mCT)imaging.mCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls.mCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice.No significant differences were observed for the tooth and pulp chamber volume.Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width.Taken together,these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin. | Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt Michaela Kneissel Reinhard Gruber | 2014 | International Journal of Oral Science2014，6，2： | 7 |
| 3 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | 2012 (9851)2012，，9851： | 3 |
| 4 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | The Lancet2012，，9851： | 2 |
| 5 | Motor recovery after early brain damage显示文摘 | Sabatini U Toni D Pantano P | 1994 | Stroke1994，25，： | 2 |
| 6 | Mesh optimization显示文摘 | HUGUES H TONY D TOM D | 1994 | Computer Aided Geometric Design1994，11，2： | 1 |
| 7 | Neurological deterioration in acute ischemic stroke - Potentialpredictors and associated factors in the European Cooperative Acute Stroke Study (ECASS) I显示文摘 | Davalos A Toni D Iweins F | 1999 | Stroke1999，30，： | 1 |
| 8 | Prediction of stroke deterioration显示文摘 | Toni D | 1997 | Cerebrovasc Dis1997，7，5： | 1 |
| 9 | GeocenterMotions from GPS: A Unified Observation Model显示文摘 | David A’Lavalle'e Tonie van D | 2006 | Journal of Geophysical Research2006，111，05： | 1 |
| 10 | Neurological deterioration in acute ischemic stroke:potential predictors and associated factors in the European cooperative acute stroke study (ECASS) I显示文摘 | Davalos A Toni D Iweins F | 1999 | Stroke1999，30，12： | 1 |
| 11 | Wavelets for computer graphics : A primer, Part2 显示文摘 | Eric J Stollnitz Tony D DeRose David H Salesin | 1995 | IEEE Computer Graphics and Applications1995，15，4： | 1 |
| 12 | The TEST - 1 Automated System A New Method For Measuring the Erythrocyte Sedimentation Rate显示文摘 | MARIO PLEBANI M D STEFANIA DE TONI M D | 1998 | American Journal of Clinical Pathology1998，11，3： | 1 |
| 13 | Prognostic significance of admission levels of troponin I in patients with acute ischemic stroke 显示文摘 | Angelantonio E Fiorelli M Toni D | 2007 | Neurol Neurosurg Psychiatry2007，76，1： | 1 |
| 14 | Relationship between vascular enhancement,cerebral hemodynamics,and MR angiography in cases of acute stroke显示文摘 | Pantano P Toni D Caramia F | 2001 | Am J Neuroradiol2001，22，2： | 1 |
| 15 | A method for improving SELDI-TOF mass spectrometry data Quality 显示文摘 | Whistler Toni Rollin Dominique Vernon Suzanne D | 2007 | ProteomeScience(S1477-5956)2007，5，9： | 1 |
| 16 | Instrumentation of an unsaturated expansive soil slope显示文摘 | Zhan Tony L T Ng Charls W W Fredlund D G | 2007 | Geotechnical Testing Journal2007，30，2： | 1 |
| 17 | Clinical outcomes with Erlo tinib in patients with epidermal growth factor receptor mutation(NEJGSG002) 显示文摘 | Tony SK Manolo D Raffaele C | 2012 | Drugs2012，，72： | 1 |
| 18 | Mechanobiology of mandibular distraction osteogonsis finite element analyse显示文摘 | Elizabeth G Tony D David W | 2005 | Journal of Orthopaedic Research2005，23，3： | 1 |
| 19 | Intravenous thrombolysis in young stroke patients: results from the SITS-ISTR显示文摘 | TONI D AHMED N ANZINI A | 2012 | Neurology2012，78，12： | 1 |
| 20 | Neurological deterioration in a-cute ischemic stroke potential predictors and associated factors in the European cooperative acute stroke study (ECASS)显示文摘 | Davalos A Toni D Iweins F | 1999 | Stroke1999，30，12： | 1 |
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