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| 1 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 2 | Cystic fibrosis transmembrane conductance regulator functional evaluations in a G542X+/-IVS8Tn:T7/9 patient with acute recurrent pancreatitis显示文摘BACKGROUND Acute recurrent pancreatitis(ARP)is characterized by episodes of acute pancreatitis in an otherwise normal gland.When no cause of ARP is identifiable,the diagnosis of'idiopathic'ARP is given.Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR)gene increase the risk of ARP by 3-to 4-times compared to the general population,while cystic fibrosis(CF)patients present with a 40-to 80-times higher risk of developing pancreatitis.CASE SUMMARY In non-classical CF or CFTR-related disorders,CFTR functional tests can help to ensure a proper diagnosis.We applied an individualized combination of standardized and new CFTR functional bioassays for a patient referred to the Verona CF Center for evaluation after several episodes of acute pancreatitis.The CFTR genotype was G542X+/-with IVS8Tn:T7/9 polymorphism.The sweat(Cl-)values were borderline.Intestinal current measurements were performed according to the European Cystic Fibrosis Society Standardized Operating Procedure.Recent nasal surgery for deviated septum did not allow for nasal potential difference measurements.Lung function and sputum cultures were normal;azoospermia was excluded.Pancreas divisum was excluded by imaging but hypoplasia of the left hepatic lobe was detected.Innovative tests applied in this case include sweat rate measurement by image analysis,CFTR function in monocytes evaluated using a membrane potential-sensitive fluorescent probe,and the intestinal organoids forskolin-induced swelling assay.CONCLUSION Combination of innovative CFTR functional assays might support a controversial diagnosis when CFTR-related disorders and/or non-classical CF are suspected. | Sara Caldrer Gabriella Bergamini Angela Sandri Silvia Vercellone Luca Rodella Angelo Cerofolini Francesco Tomba Filippo Catalano Luca Frulloni Mario Buffelli Gloria Tridello Hugo de Jonge Baroukh Maurice Assael Claudio Sorio Paola Melotti | 2019 | World Journal of Clinical Cases2019，7，22： | 2 |
| 3 | The Evaluation of Family Functioning by the Family Assessment Device: A Systematic Review of Studies in Adult Clinical Populations显示文摘 | Laura Staccini Elena Tomba Silvana Grandi Gabor I. Keitner | 2015 | Fam. Proc2015，，： | 2 |
| 4 | Alumina disks with different surface finish:Thermal shock behavior显示文摘 | Tomba A G Cavalieri A L | 2000 | Journal of the European Ceramic Society2000，，20： | 1 |
| 5 | On the effect of wiener phase noise in OFDM systems 显示文摘 | Tomba L | 1998 | IEEE Transactions on Communications1998，46，5： | 1 |
| 6 | Automatic characterization of nanofiber assemblies by image tex- ture analysis 显示文摘 | FACCO P TOMBA E ROSO M | 2010 | Chemometrics and Intelligent Labora- tory Systems2010，103，1： | 1 |
| 7 | Physical characterization of commercial polyole? nic thermo- plastic elastomers 显示文摘 | MONTOYA M PABLO TOMBA J CARELLA J M | 2004 | Eur Polym J2004，40，： | 1 |
| 8 | Increasing psychological well-being and resili- ence by psychotherapeutic methods 显示文摘 | Fava GA Tomba E | 2009 | J Pers2009，77，6： | 1 |
| 9 | On the effect of wiener phase noise in OFDM systems显示文摘 | Tomba L | 1998 | IEEE Trans on Commun1998，46，5： | 1 |
| 10 | Increasing psychological well-being and resil- ience by psychotherapeutic methods 显示文摘 | Fava GA Tomba E | 2009 | J Pets2009，77，6： | 1 |
| 11 | Mechanical testing of cordierite porous ceramics using high temperature diametral compression 显示文摘 | SANDOVAL M L TALOU M H TOMBA MARTINEZ A G | 2010 | J Eur Ceram Soc2010，45，18： | 1 |
| 12 | On the Effect of Wiener Phase Noise inOFDM Systems 显示文摘 | Luciano Tomba | 1998 | Communications IEEE Transactions1998，46，5： | 1 |
| 13 | Creep behavior modeling of silica fume containing A1203-MgO refractory castables显示文摘 | Tomba Martinez A G Luz A P Braulio M A L | 2012 | Ceramics International2012，38，： | 1 |
| 14 | Solid state and liq- uid ablation of polyethylene - glycol 1000: temperature dependence显示文摘 | B Hopp T Smausz E Tomba'cz | 2000 | Optics Communications2000，181，46： | 1 |
| 15 | Enteroscopy for the early detection of small bowel tumours in at-risk celiac patients显示文摘 | Tomba C Elli L Bardella MT | 2014 | Dig Liver Dis2014，46，5： | 1 |
| 16 | Increasing psychological well-being and resili- ence by psychotherapcutic methodst显示文摘 | Fava GA Tomba E | 2009 | J Pets2009，77，6： | 1 |
| 17 | On the effect of Wiener phase noise in OFDM systems 显示文摘 | Tomba L | 1998 | IEEE Trans Commun1998，46，： | 1 |
| 18 | Alumina Disks with Different Surface Finish :Thermal Shock Behavior显示文摘 | Tomba A G Cavalieri A L | 2000 | Journal of the European Ceramic Society2000，20，： | 1 |
| 19 | Equalization methods in OFDM and FMT system for broadband wireless communications显示文摘 | N Benvenuto S Tomasin L Tomba | 2002 | IEEE Transactions on Communications2002，50，9： | 1 |
| 20 | Latent variable modeling to assist the implementation of quality-by-design paradigms in pharmaceutical development and manufacturing: a review显示文摘 | Tomba E Facco P | 2013 | International Journal of Pharmaceutics2013，74，8： | 1 |
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