|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease显示文摘BACKGROUND Matrix Gla protein(MGP)is a vitamin K dependent peptide which has an established role in suppression of vascular calcification.Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel disease(IBD).AIM To compare plasma levels of dephosphorylated and uncarboxylated MGP(dpucMGP)between IBD patients and controls.METHODS This cross-sectional study was conducted on 70 patients with IBD(30 patients with ulcerative colitis and 40 patients with Crohn’s disease)and 60 age and gender matching healthy controls.Plasma dp-ucMGP levels were analyzed from blood samples by CLIA method using IDS-iSYS InaKtif MGP(Immunodiagnostic Systems,Frankfurt,Germany)according to the manufacturer's instructions.fecal calprotectin(FC)levels were determined from stool samples by turbidimetric immunoassay method using Bühlmann fecal calprotectin turbo assay(Bühlmann Laboratories Aktiengesellschaft,Schonenbuch,Switzerland).Other parameters were analyzed according to the standard laboratory procedures.RESULTS Plasma levels of dp-ucMGP were significantly higher in patients with IBD compared to the healthy control group(629.83±124.20 pmol/mL vs 546.7±122.09 pmol/mL,P<0.001),and there was no significant difference between patients with Crohn’s disease and patients with ulcerative colitis(640.02±131.88 pmol/mL vs 616.23±113.92 pmol/mL,P=0.432).Furthermore,a significant positive correlation of plasma dp-ucMGP levels was found with both FC levels(r=0.396,P<0.001)and high sensitivity C-reactive protein(hsCRP)levels(r=0.477,P<0.001).Moreover,in the total study population a significant positive correlation was found between dp-ucMGP with age(r=0.210,P=0.016)and waist circumference(r=0.264,P=0.002).Multiple linear regression analysis showed that dp-ucMGP levels retained significant association with FC(β±SE,0.06±0.02,P=0.003).CONCLUSION Study results support experimental data of MGP immunomodulatory IBD effect and indicate potential involvement in the pathophysiology of the disease,and possibly extraintestinal manifestations. | Darko Brnic Dinko Martinovic Piero Marin Zivkovic Daria Tokic Marino Vilovic Doris Rusic Ivana Tadin Hadjina Christian Libers Sandro Glumac Daniela Supe-Domic Ante Tonkic Josko Bozic | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 2 | Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘 | Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger | 2005 | Critical Care Medicine2005，，3： | 2 |
| 3 | Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia显示文摘 | Gunnarsson L Tokics L Gustavsson H | 1991 | Br J Anaesth1991，66，4： | 1 |
| 4 | Constitutional factors promoting development of atelectasis during anaesthesia 显示文摘 | Strandberg A Tokics L Brismar B | 1987 | Acta Anaesthesiol Scand1987，31，1： | 1 |
| 5 | Numerical calculations of three-phase transformer transients显示文摘 | Tokic A Madzarevic V Uglesic I | 2005 | IEEE Trans on Power Delivery2005，20，4： | 1 |
| 6 | Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis显示文摘 | Hedenstierna G Tokics L Strandberg A | 1986 | Acta Anaesthesiol Scand1986，30，2： | 1 |
| 7 | V/Q distribution and correlation to ateletasis in anesthetize paralyzed humans显示文摘 | Tokics L Hedenstirna G Svensson L | 1996 | J Appl Phsiol1996，81，4： | 1 |
| 8 | V/Q distribution and correlation to ateletasis in anesthetized paralyzed hu mans显示文摘 | Tokics L Hedenstierna G Svensson L a al | 1996 | JApplPhysiol1996，81，4： | 1 |
| 9 | Atelectasis and lung function in the postoperative period显示文摘 | Lindberg P Gunnarsson L Tokics L | 1992 | Acta Anaesthesiol Scand1992，36，6： | 1 |
| 10 | Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia显示文摘 | Gunnarsson L Tokics L Gustavsson H | | 0，，04： | 1 |
| 11 | Pneumonia asthe most common lower respiratory tract infection显示文摘 | Biscevic-Tokic J Tokic N Musanovic A | 2013 | MedArch2013，67，6： | 1 |
| 12 | Rational destabilizing speculation, positive feedback trading, and the oil bubble of 2008显示文摘 | Damir Tokic | 2011 | Energy Policy2011，，4： | 1 |
| 13 | Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia显示文摘 | Gunnarsson L Tokics L Gustavsson H | 1991 | Br J Anaesth1991，66，： | 1 |
| 14 | Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis显示文摘 | Hedenstierna G Tokics L Strandberg A | | 0，，02： | 1 |
| 15 | Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘 | Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger | 2005 | Critical Care Medicine2005，，3： | 1 |
| 16 | Atelectasis during anaesthesia and in the postoperative period 显示文摘 | Strandber A Tokics L Brismar B | 1986 | Acta Anaesthesiol Scand1986，30，： | 1 |
| 17 | Influence of age on atelectasis for mation and gas exchange impairment during general anaesthesia显示文摘 | Gunnarsson L Tokics L Gustavsson H | 1991 | Br J Anaesth1991，66，4： | 1 |
| 18 | Lung collapse and gas exchange during general anesthesia; Effects of spontaneous breathing,muscle paralysis,and positive end-expiratory pressure显示文摘 | Tokics L Hedenstierna G Strandberg A | 1987 | Anesthesiology1987，66，2： | 1 |
| 19 | Lung collapse and gas exchange during general anesthesia:effets of spontaneous breathing,muscle paralysis,and positive end-expiratory pressure显示文摘 | Tokics L Hedenstiema G Strandberg A | | 0，，02： | 1 |
| 20 | Lung collapse and gas exchange during general anesthesia:effects of spontaneous breathing,muscle paralysis,and positive end-expiratory pressure显示文摘 | Tokics L Hedenstierna G Strandberg A | 1987 | Anesthesiology1987，66，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员