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| 1 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 2 | Prognostic influence of increased fibrinogen and C - reactive protein levels in unstable coronary artery disease显示文摘 | Toss H Lindahl B Siegbahn A | 1998 | Eur Heart J1998，19，： | 1 |
| 3 | Restoration of wild type PTRN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cell 显示文摘 | Tian XX Pang JC ToSS | 2002 | Neuropathol EXP Neurlol2002，58，5： | 1 |
| 4 | Effect of milrinone on contractile responses of guinea pig trachea,lung parenchyma and pulmonary artery显示文摘 | Drazen JM | 1986 | J Pharmacol Exp Ther1986，238，： | 1 |
| 5 | Acceptability andadherence in a chemoprevention trial among women at increasedrisk for breast cancer attending the Modena Familial Breast andOvarian Cancer Center (Italy) 显示文摘 | Razzaboni E Toss A Cortesi L | 2013 | Breast J2013，19，1： | 1 |
| 6 | Common biochemical markers of bone turnover predict future bone loss: A 5-year follow-up study 显示文摘 | Owe Lffmana Per Magnussonb Gfran Toss | 2005 | Clinica Chimica Acta2005，356，： | 1 |
| 7 | Interferon-alpha in treatment of chronic hepatitis C in co-infected HIV-patients in combination with ribavirin and as a pre-load therapy in treatment-naive HIV-positive patients 显示文摘 | TOSSING G | 2002 | European Journal of Medicinal Research2002，7，1： | 1 |
| 8 | Markers of myocar- dial damage and inflammation in relation to long-term mortality in unstable coronary artery disease显示文摘 | Lindahl B Toss H Siegbahn A | 2000 | N Engl J Med2000，343，16： | 1 |
| 9 | Weight loss,body fat mass,and leptin in Parkinson's disease显示文摘 | Loreflt B Toss G Granérus AK | 2009 | Mov Disord2009，24，6： | 1 |
| 10 | Acroioclavicular separations:useful and practical classification for treatment显示文摘 | Toss JD Mead NC Sigmond HM | 1963 | Clin Orthop1963，，28： | 1 |
| 11 | Prognostic influence of increased fibrinogen and C-renctive protein levels in unstable corollary artery Disease显示文摘 | Toss H Lindahl B Siegbahn A | 1997 | Circulation1997，96，12： | 1 |
| 12 | Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea 显示文摘 | I-Iellum B H Tosse A Hoybakk K | 2010 | Planta Med2010，76，4： | 1 |
| 13 | Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease显示文摘 | TOSS H LINDADHL B SEIBAHN A | 1997 | Circulation1997，96，： | 1 |
| 14 | Prognostic influence of increased fibrinogen and C-reactive protein level in un- stable coronary artery disease显示文摘 | Toss H Lindahl B Siesbahn A | 1997 | Circulation1997，96，12： | 1 |
| 15 | Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease;FRISC Study Group显示文摘 | Lindahl B Toss H Siegbahn A | 2000 | N Engl J Med2000，343，： | 1 |
| 16 | Common biochemical markers of bone turnover predict future bone loss a 5-year follow-up study显示文摘 | LOFMAN O MAGNUSSON P TOSS G | 2005 | Clin Chim Acta2005，356，12： | 1 |
| 17 | Prognostic influence of increased fibrinogen and C - reactive protein levels in unstable corollary artery Disease显示文摘 | Toss H Lindahl B Siegbahn A | 1997 | Circulation1997，96，12： | 1 |
| 18 | Common biochemical markers of bone turnover predict future bone loss:a 5-year follow-up study显示文摘 | Lofman O Magnusson P Toss G | 2005 | Clin Chim Acta2005，356，12： | 1 |
| 19 | Markers of myocardial damage and inflammation in relation to long term mortality in unstable coronary artery disease显示文摘 | Lindahl B Toss H Siegbahn A | 2000 | N Eng J Med2000，343，16： | 1 |
| 20 | Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease显示文摘 | Toss H Lindahl B Siebahn A el al | 1997 | Circulation1997，96，： | 1 |
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