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| 1 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 2 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 3 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 4 | B/phasic changes in Hypothalamo- pituitary-adrenal function during the early recovery period after major abdominal surgery 显示文摘 | Na/to Y Fukma J Tamai S | 1991 | J Clin Endocrinal Metab1991，73，1： | 1 |
| 5 | Early interleukin 4-dependent response can induce airway hyperreacfivity before development of airway inflammation in a mouse model of asthma显示文摘 | To Y Dohi M Tanaka R | 2001 | Lab Invest2001，81，10： | 1 |
| 6 | Characterisation of gas phase organic emissions from hot cooking oil in commercial kitchens 显示文摘 | To W M Yeung L L Chao C Y H | 2002 | Indoor Built Environment2002，9，： | 1 |
| 7 | leaves grown at sub-optimal temperature显示文摘 | Haldimann P Fracheboud Y Stamp E Photosynthetic performance and resistance to photoinhibition of Zea mays L | 1996 | Plant Cell Envrionment1996，19，： | 1 |
| 8 | Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components显示文摘 | Li Y Tollefsbol TO | 2010 | Curr Med Chem2010，17，20： | 1 |
| 9 | Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability显示文摘 | Law JH Li Y To K | 2010 | PLoS One2010，5，12： | 1 |
| 10 | Intraocular pressure elevation following triamcinolone acetonide administration as related to administration routes 显示文摘 | Hirano Y Nozaki M | 2009 | Jpn J Ophthalmol2009，53，5： | 1 |
| 11 | Targeting phosphoinositide-3-kinasedelta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease 显示文摘 | To Y Ito K Kizawa Y | 2010 | Am J Respir Crit Care Med2010，182，7： | 1 |
| 12 | Prevanlence and geographic distribution of childhood obesity in China in 2005 显示文摘 | JI C Y CHENG TO | 2008 | Int Cardiol2008，131，1： | 1 |
| 13 | The sorption of lead( II ) ions on peat显示文摘 | to Y S McKay G | 1999 | Water Res1999，33，2： | 1 |
| 14 | Application of an expert against snow accretion on transmission lines 显示文摘 | Nara K Yamashiro S system to decisions on Yanaura Y | 1988 | IEEE Transactions on Power Sys-terns1988，3，3： | 1 |
| 15 | Wu:Father of cardiothoracic surgery in China显示文摘 | Cheng TO Doctor Y K | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 16 | Use of EBSD to Study Stress Induced Microstructural Changes in Zn-Al Based Alloy显示文摘 | Zhu Y H Lee W B to S | 2003 | Materials Science and Engineering2003，348，： | 1 |
| 17 | FKF1 conveys timing information for Constans stabilization in photoperiodic flowering显示文摘 | SONG Y H SMITH R W TO B J | 2012 | Science2012，336，6084： | 1 |
| 18 | Interspecies transmission and emergence of novel viruses:lessons from bats and birds显示文摘 | Chan J F To K K Tse H Jin D Y Yuen K Y | 2013 | Trends Microbiol2013，21，： | 1 |
| 19 | Molecular character- ization of ribulose- 1,5 -bisphosphate carboxylase/ox- ygenase activase in rice leaves 显示文摘 | TO K Y SUEN D F CHEN S C G | 1999 | Planta1999，209，1： | 1 |
| 20 | Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of bisphenol A 显示文摘 | Nakamura K Itoh K Yaoi T Fujiwara Y Sugimo- to T Fushiki S | 2006 | J Neurosci Res2006，64，6： | 1 |
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