|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Emerging role of Hippo pathway in gastric and othergastrointestinal cancers显示文摘More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis. | Wei Kang Alfred SL Cheng Jun Yu Ka Fai To | 2016 | World Journal of Gastroenterology2016，22，3： | 11 |
| 3 | The record of paleoclimatic change from stalagmites and the determination of termination II in the south of Guizhou Province, China显示文摘A high-resolution climate record from 163.00 kaBP to 113.80 kaBP has been obtained through TIMS-U series dating and carbon and oxygen isotope analysis of the three large stalagmites from two caves in the south of Guizhou Province, China. The record of the oxygen isotopes from the stalagmites reveals that the undulation characteristics between the cooling event of the glacial period and the warming event of the interglacial period in the research area can compare well to those of ice cores, lake sediments, loess and deep sea sediments on the scale of ten-thousand years or millennium time scale. The climate undulation provided by the record of the stalagmites has a coherence with the global changes and a tele-connection to the paleoclimate changes in the north polar region. Our results suggest that the direct dynamics of paleo-monsoon circulation changes reflected in the record of the stalagmites might be caused by changes of the global ice volume, and in turn related to various factors, including the solar radiation strength at the mid-latitudes in the Northern Hemisphere, the southern extension of the ice-rafted event in the North Atlantic, and changes of the equatorial Pacific sea surface temperature at the low-latitudes. Using δ18O values, we have calculated the temperatures and the results show that the temperature difference between the penultimate glacial period (with an average temperature of 8.1℃, and a minimum temperature range from 0.65℃ to -1.43℃ at stage 6 ) and the last interglacial period (with an average temperature of 18.24℃ at sub-stage 5e ) was about 10℃. This temperature difference from the record of the stalagmites corresponds in general to the record temperature variation (about 10℃) of measured ice cores. The climate records from the three stalagmites in the two caves have shown that the circulation strength of the Asian summer monsoon and the winter monsoon in the penultimate glacial period and the last interglacial period had a clear change. With the TIMS-U series method, termination II of the penultimate glacial period has been precisely dated at an age of (129.28±1.10) kaBP for the three stalagmites in the south of Guizhou Province, China. This borderline age represents the beginning of the last interglacial period or the boundary between the Middle Pleistocene and the Late Pleistocene, and corresponds to the beginning age of the last interglacial period shown by the ice cores and in the SPECMAP curve of the marine oxygen isotopes. The chronology determination of termination II is not only of stratigraphic and chronological significance, but also lays an important foundation for discussing the short time scales of climate oscillation and rapidly changing events of paleoclimate in the circulation region of the East Asian monsoon. | ZHANG Meiliang, YUAN Daoxian1, LIN Yushi, CHENG Hai, QIN Jiaming &ZHANG HuilingKarst Dynamics Laboratory, Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004, China Geography Department, Minnesota University, MN 55455, USA Correspondence should be addressed to Zhang Meiliang | 2004 | Science China Earth Sciences2004，47，1： | 9 |
| 4 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 5 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 6 | Synthesis of vertically aligned carbon nanotube arrays on silicon substrates显示文摘The growth of well-aligned carbon nanotube (CNT) arrays using a heat chemical vapor deposition system on silicon substrates is reported. The growth properties of CNT arrays are studied as a function of synthesis conditions. It is found that 750℃ and 10 nm Fe film are suitable conditions for the growth of well-aligned CNT arrays. CNT arrays with a uniform diameter, thick tube wall and firm cohesion to the Si substrate can be grown for C2H2 concentration of 27%. Based on the experiment, the processes of improving the alignment of CNT arrays and cohesion between CNT arrays and Si substrates are discussed. | ZHENG Ruiting1, CHENG Guoan1, PENG Yibin1, 2, ZHAO Yong1, 3, LIU Huaping1 & LIANG Changlin1 1. Key Laboratory of Radiation Beam Technology and Materials Modification of Ministry of Education, Department of Materials Science and Engineering, Beijing Normal University, Beijing 100875, China 2. School of Science, Civil Aviation University of China, Tianjin 300300, China 3. Department of Physics, Nanchang University, Nanchang 330047, China Correspondence should be addressed to Zheng Ruiting | 2004 | Science China(Technological Sciences)2004，47，5： | 4 |
| 7 | Adsorption and Desorption of Gold on the Magnetic Activated Carbon显示文摘Adsorption and desorption of gold on the magnetic activated carbon (MAC) were investigated The adsorption rate of gold is higher than that of conventional coconut carbon in cyanide leach solution The loading gold can be easily desorbed as coconut carbon. Crushed fine magnetic carbon can be selected by a magnetic separator, It is suggested that the MAC can be used in carbon-in-pulp (CIP)process for increasing the recovery rate of | Chonglin WANG Qingcai LIU Xiaozhen CHENG and Zuhong SHEN (Institute of Metal Research, Academia Sinica, Shenyang, 110015, China)(To whom correspondence should be addressed) | 1994 | Journal of Materials Science & Technology1994，10，2： | 3 |
| 8 | 冠心病心衰显示文摘充血性心力衰竭影响近1%人群。在过去的10年中,其发生率持续增高。Framingham 地区32年的随访研究表明冠心病仅次于高血压,是心衰的第二最常见原因,占男性心衰病例之46%;女性之27%。心肌缺血及 AMI 的治疗进展使存活期延长,可能为冠心病心衰增加的原因。冠心病心衰发生率增加,迫使人们去研究有关的病理生理机制,提出新的药物干预治疗措施,以防止疾病发展。 | Cheng TO 孙福成 | 1991 | 国外医学(心血管疾病分册)1991，18，4： | 3 |
| 9 | Thermodynamic characterization of two novel spin-crossover complexes显示文摘Two novel FeII spin crossover complexes [Fe(L1)3](BF4)25H2O (1) and [Fe(L2)3](BF4)2·2H2O (2) with 4-NHR-1,2,4-triazole (R = isopropyl, L1; cyclohexyl, L2) were synthesized. 1 and 2 remain white at room temperature, whereas they turn purple at liquid temperature. Variable temperature optical detection and magnetic susceptibilities measurement show that the spin-crossover phenomenon for 1 was observed between 120 K and 170 K. The hysteresis loop is about 10 K. The Tc temperature of 2 is 190 K, but no thermal hysteresis loop was found. The molar thermodynamic functions and the microscopic parameters were obtained from the theoretical analysis in terms of the domain model, two level Ising model and regular solution model, respectively. | DING Bin, WANG Hongmei, YI Long, CHENG Peng, LI Licun, ZHAI Yuping, LIAO Daizheng, YAN Shiping & JIANG Zonghui Department of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to Cheng Peng or Liao Daizheng (e-mail: pcheng@nankai.edu.cn) | 2003 | Chinese Science Bulletin2003，48，22： | 3 |
| 10 | Formation of domain structure of erythrocyte membrane in Wistar rat fed with CeCl_3per os显示文摘To explore the possibility of absorption of lanthanides via digestive duct and their effects on one membrane structure and permeability of erythrocytes, the fine structure of erythrocyte membrane from Wistar rats, fed for 70 days of daily administration per os with 20 mg CeCl3/kg weight, was imaged by means of atomic force microscopy and FT-IR deconvolution spectra. The results show that, although the erythrocytes maintain the intact shape, the change OT secondary structure, aggregation and crosslinking of the protein particles of membrane surface and the enlarged lipid regions lead to the domain structure formation. This structure might be responsible for the increasing permeability of erythrocyte membrane. | CHENG Yi, LIU Maozi, LI You, LI Rongchang, BAI Chunli & WANG Kui National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Wang Kui | 2000 | Chinese Science Bulletin2000，45，5： | 3 |
| 11 | In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli显示文摘Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully understood.We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation.To investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in mice.Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes.Chemogenetic inhibition of neurons augmented the astrocytic activity.These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment. | Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai Li Zhang Kwok-Fai So Edward S.Yang | 2022 | Neural Regeneration Research2022，17，11： | 2 |
| 12 | Synthesis and magnetic properties of one-dimensional Mn(Ⅱ)complexes linked by dithiooxalato显示文摘Three dithiooxalato (Dto) bridging one-dimensional Mn(Ⅱ) complexes [Mn(L)Dto](L = Phen (1), Bpy (2) and en (3)) were synthesized. All of the complexes have the similar one-dimensional structure through Dto bridge. The measurement of the variable temperature magnetic susceptibility of complex 1 showed that there are weak antiferromag- netic interactions between the Mn(Ⅱ) ions. | CUI Jianzhong, SHI Wei, CHENG Peng, CHEN Xufang, LIAO Daizheng, YAN Shiping, JIANG Zonghui & WANG GenglinDepartment of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to Cheng Peng (e-mail: pcheng@ nankai.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 2 |
| 13 | Real-time 3-Dimensional echocardiography: a review of the development of the technology and its clinical application 显示文摘 | Xie Mingxin Wang Xinfang Cheng TO | 2005 | Progress in Cardiovascular Diseade2005，48，3： | 1 |
| 14 | Four-dimensional echocardio graphy: methods and clinical application显示文摘 | Wang XF Li ZA Cheng TO | 1996 | Am Heart J1996，132，3： | 1 |
| 15 | Percutaneous transluminal sptal myocardial ablation for hypertrophic obstructive cardiomyopathy: The Chinese experience in 119 patients from a single center显示文摘 | Li ZQ Cheng TO Zhang WW | 2004 | International Journal of Cardiology2004，93，23： | 1 |
| 16 | Cigarette smoking,asthma,and emphysema显示文摘 | Cheng TO | 2003 | Chest2003，124，6： | 1 |
| 17 | Obesity crisis comprised of danger and opportunity显示文摘 | Cheng TO | 2004 | J Am Diet Assoc2004，104，： | 1 |
| 18 | Use of Myocardial biopsy catheter in retrieving 'lost' intracardiac device显示文摘 | Cheng TO | | 0，，： | 1 |
| 19 | Real-time 3-dimensional echocardiography in assessing atrial and ventricular septal defects: An echocardiographic-surgical correlative study 显示文摘 | Cheng TO Xie MX Wang XF | 2004 | American Heart Journal2004，148，： | 1 |
| 20 | Prevanlence and geographic distribution of childhood obesity in China in 2005 显示文摘 | JI C Y CHENG TO | 2008 | Int Cardiol2008，131，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员