|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | cytoplasmic domain of tissue factor promotes liver fibrosis in mice显示文摘AIM To evaluate the role of tissue factor(TF) and protease activated receptor(PAR)-2 in liver fibrosis.METHODS Using CCl4 administration for eight weeks, we induced hepatic fibrosis in wild-type C57BL/6 mice and in mice with deletion of the cytoplasmic signalling domain of TF(TF§CT/§CT), deletion of PAR-2(PAR-2-/-) and combined deletion of TF signalling domain and PAR-2(TF§CT/§CT/PAR-2-/-). Hepatic fibrosis area was assessed by quantitative imaging of picrosirius red staining. Hepatic collagen content was assessed by hydroxyproline levels. Hepatic stellate cells(αSMA positive) and hepatic macrophages(CD68 positive) were identified by immunohistochemistry. Hepatic gene expression was determined by PCR and liver TGFβ1 content by ELISA.RESULTS CCl4 treated mice with deletion of the PAR-2 gene(PAR-2-/-) and the cytoplasmic domain of TF(TF§CT/§CT) developed significantly less hepatic fibrosis, characterised by reduced liver fibrosis area and hydroxyproline content, compared to control wildtype mice treated with CCl4. The observed reduction in histological fibrosis was accompanied by a significant decrease in the hepatic content of TGFβ, the prototypic fibrogenic cytokine, as well as fewer activated hepatic stellate cells and hepatic macrophages. Deletion of the TF cytoplasmic signalling domain reduced hepatic fibrosis to levels similar to thoseobserved in mice lacking PAR-2 signalling but combined deletion provided no added protection against fibrosis indicating a lack of mutual modulating effects that have been observed in other contexts such as angiogenic responses.CONCLUSION Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. | Virginia Knight Dinushka Lourensz Jorge Tchongue Jeanne Correia Peter Tipping William Sievert | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 2 | A survey of program slicing techniques显示文摘 | Tip F | 1995 | J Programming Languages1995，3，3： | 2 |
| 3 | Immune regulation by CD52-expressing CD4 T cells显示文摘由表示 CD52 CD4 T 房间的 T 房间规定看起来操作由二不同并且可能 synergistic 机制。第一由它从表示那然后绑在由损害 T 房间受体的 phosphorylation 稀释受动器 T 房间激活的酸绑定的像免疫球蛋白的 lectins-10 (Siglec-10 ) 受体联系了的禁止的 sialic 的 CD52 的高水平的 CD4 T 房间的房间表面的版本 lck 和 zap-70。第二机制看起来由由被导致他们的扩大的二原子价的 anti-CD52 抗体模仿的迄今为止未辩别出的内长的 ligand 的 CD52 分子的 crosslinkage。 | Ban-Hock Toh Tin Kyaw Peter Tipping Alex Bobik | 2013 | Cellular & Molecular Immunology2013，10，5： | 2 |
| 4 | A unifying model of cation binding by humic substances显示文摘 | Tipping E and Hurley M A | 1992 | Geochim cosm ochim acta1992，56，： | 2 |
| 5 | Sparse Bayesian Learning and the Relevance Vector Machines 显示文摘 | TIPPING M E | 2001 | Journal of Machine Learning Research2001，1，2： | 1 |
| 6 | Continuous venovenous hemofiltration with dialysis removes cytokines fromthe circulation of septic patients显示文摘 | Bellomo R Tipping P Boyce N | 1993 | Crit Care Med1993，21，4： | 1 |
| 7 | A survey of program slicing techniques显示文摘 | Tip E | 1995 | Journal of Programming Languages1995，3，： | 1 |
| 8 | A survey of program slicing techniques显示文摘 | Tip F | 1995 | Journal of Programming Languages1995，3，3： | 1 |
| 9 | 显示文摘 | Geusic J E Tipping D W | 1969 | Phys Rev Lett1969，19，： | 1 |
| 10 | will transcatheter tmbolitherapy replace surgery in the treatment of gastroinlestinal bleeding显示文摘 | Patel TIP Cordis PR Abcarian P | 2001 | Curr Surg2001，58，3： | 1 |
| 11 | Probabilistic principal component analysis显示文摘 | TIPPING M BISHOP C | 1999 | Journal of the Royal Statistical Society Series B1999，21，3： | 1 |
| 12 | Sparse Bayesian learning and the relevance vector machine显示文摘 | Tipping M E | 2001 | Journal of Machine Learning Research2001，1，3： | 1 |
| 13 | T cells in crescentic glomerulonephritis显示文摘 | Tipping PG Holdsworth SR | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 14 | Bayesian inference: an introduction to principles and practice in machine learning 显示文摘 | Tipping M E | 2004 | Lecture Notes in Computer Science2004，3176，： | 1 |
| 15 | The solid-solution partitioning of heavy metals (Cu,Zn,Cd,Pb) in upland soils of England and Wales显示文摘 | Tipping E Rieuwerts J Pan G | 2003 | Environmental Pollution2003，125，： | 1 |
| 16 | Sparse Bayesian learning and the relevance vector machine 显示文摘 | Tipping M E | 2001 | J of Machine Learning Research2001，2，1： | 1 |
| 17 | Climatic influences on the leaching of dissolved organic matter from upland UK Moorland soils,investigated by a field manipulation experiment显示文摘 | Tipping E Woof C Rigg E | | 0，，： | 1 |
| 18 | Probabilistic principle component analysis显示文摘 | TIPPING M E BISHOP C M | 1999 | Journal of Royal Statistical Society1999，61，3： | 1 |
| 19 | Cloning and molecular analysis of the pea seedling copper amine oxidase 显示文摘 | Tipping A J McPherson M J | 1995 | Journal of Biological Chemistry1995，270，16： | 1 |
| 20 | Post-tensioned Concrete Walls for Seismic Resistance-an Innovative Approach to Earthquake Safety and Concrete Construction in Buildings显示文摘 | PANIAN L STEYER M TIPPING S | 2007 | Journal of the Post-tensioning Institute2007，5，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员