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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 气管内插管并发症的预防和治疗显示文摘一、气管内插管并发症的病因学 (一)病人因素:小儿插管后发生喘鸣的危险性极高,小儿气道以环状软骨环处直径最小,喉粘膜血管丰富附着松散,因此声门下极易水肿。拔管后并发症几乎都是由于声门小所致。 (二)设备因素:即使应用可屈性纤维光导喉镜操作谨慎小心仍可能发生某些并发症。例如经鼻插管可能导致鼻出血,又因气道已被麻醉,血液入肺可导致支气管阻塞。 | Quartararo C Bishop MJ 于学成 魏占军 | 1992 | 国外医学(麻醉学与复苏分册)1992，13，2： | 2 |
| 3 | GTM: The generative topographic mapping显示文摘 | Bishop C M Svensen M Williams C K I | 1998 | Neural Computation1998，10，1： | 1 |
| 4 | Probabilistic principal component analysis显示文摘 | TIPPING M BISHOP C | 1999 | Journal of the Royal Statistical Society Series B1999，21，3： | 1 |
| 5 | Identifica- tion of polymorphisms in the malic enzyme 1, NADP (+)-dependent, cytosolic and nuclear receptor sub- family 0, group B, member 2 genes and their associa- tions with meat and carcass quality traits in commercial Angus cattle显示文摘 | Gill J L Bishop S C McCorquodale C | 2012 | Anim Genet2012，43，： | 1 |
| 6 | Brassinosteroids and plant steroid hormone signaling显示文摘 | BISHOP GJ KONCZ C | 2002 | Plant Cell2002，14，： | 1 |
| 7 | Contingent Valuation of En- vironmental Assets: Comparison with a Stimulated Market 显示文摘 | Bishop R C Heberlein T A Kealy M J | 1983 | Nat- ural Resources Journal1983，23，： | 1 |
| 8 | Multivariate analysis of mainstream tobacco smoke particulate phase by headspace solid-phase micro extraction coupled with comprehensive two-dimensional gas chromatography-time-offlight mass spectrometry显示文摘 | BROKL M BISHOP L WRIGHT C G | 2014 | Journal of Chromatography A2014，1370，： | 1 |
| 9 | Activities of three digestive enzymes during development in the crayfish Procambarus clarkii (Decapoda) 显示文摘 | Hammer H S Bishop C D Watts S A | 2000 | J Crustac Biol2000，20，： | 1 |
| 10 | Virus taxonomy, 6th Report of the International Committee on Taxonomy of Viruses (ICTV) 显示文摘 | Murphy F A Fauquet C M Bishop D H L | 1995 | Arch Virol1995，10，： | 1 |
| 11 | Contigent valuation of environmental assets:comparison with a simulated market显示文摘 | BISHOP B C | 1983 | Natural Resources Journal1983，23，： | 1 |
| 12 | Homozygosityfor a single base-pair mutation in the oocyte-specificGDF9 gene results in sterility in Thoka sheep显示文摘 | Nicol L Bishop S C Pong-Wong R | 2009 | Repro-duction2009，138，6： | 1 |
| 13 | Probabilistic principle component analysis显示文摘 | TIPPING M E BISHOP C M | 1999 | Journal of Royal Statistical Society1999，61，3： | 1 |
| 14 | Human induced loading on flexible staircases 显示文摘 | Kerr S C Bishop N W M | 2001 | Engineering Structures2001，23，1： | 1 |
| 15 | Improving the generalization properties of radial basis function neural networks 显示文摘 | Bishop C | 1991 | Neural Computation1991，，3： | 1 |
| 16 | Density,porosity,and pore structure of biofilms显示文摘 | Zhang T C Bishop P L 1994 | 1994 | Water Research1994，28，11： | 1 |
| 17 | Mixtures of probabilistic principal component analyzers显示文摘 | Tipping M E Bishop C M | 1999 | Neural Computation1999，11，2： | 1 |
| 18 | Infrared spectroscopic analyses on the nature of water in montmorillonite显示文摘 | BISHOP J L PIETERS C M EDWARDS J O | 1994 | Clays Clay Miner1994，42，： | 1 |
| 19 | Identification of inport residues in metal-chelate recognition by monoclonal antibodies显示文摘 | Delehanty James B Jones R M Bishop T C | 2003 | Biochemistry2003，42，14： | 1 |
| 20 | Pattern recognition and machine leaming显示文摘 | Bishop C M | 2006 | J of Electronic Imaging2006，16，4： | 1 |
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