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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Interactive effect of dissolved organic matter and phenanthrene on soil enzymatic activities显示文摘The investigation of dissolved organic matter(DOM) on urease,catalase and polyphenol oxidase activity in a phenanthrene(Phe)contaminated soil was conducted under laboratory incubation conditions.Values of soil enzymatic activity depended mainly on incubation time.In the initial 16 days,urease activity increased,and was followed by a decrease.In the initial 8 days,catalase activity decreased and then increased.Variation of polyphenol oxidase activity was just the reverse of catalase activity.After 30 days of incubation,no pronounced difference among treatments with Phe,Phe and DOM,and control were detected in urease,catalase and polyphenol oxidase activity.Phe might inhibit urease and catalase,and stimulate polyphenol oxidase.DOM could improve inhibition of Phe in soil urease and catalase activity during the initial period of applying DOM.Nevertheless,DOM had no significant effect on polyphenol oxidase activity in the Phe contaminated soil.There was a negative correlation between catalase and polyphenol oxidase(r =-0.761***),and catalase and urease(r =-0.554**).Additionally,a positive correlation between polyphenol oxidase and urease was also detected(r = 0.701***).It is implied that the formed DOM after application of organic wastes into soils may counteract the inhibition of polycyclic aromatic hydrocarbons in soil enzyme activities. | Xinhua Zhan,Wenzhu Wu,Lixiang Zhou,Jianru Liang,Tinghui Jiang College of Resources and Environmental Sciences,Nanjing Agricultural University,Nanjing 210095,China.Greenstar Plant Products Inc.,9430 198 St,Langley,BC,Canada V1M3C8. | 2010 | Journal of Environmental Sciences2010，22，4： | 10 |
| 3 | Effect of rGO Coating on Interconnected Co_3O_4 Nanosheets and Improved Supercapacitive Behavior of Co_3O_4/rGO/NF Architecture显示文摘In this study, the effect of reduced graphene oxide(rGO) on interconnected Co_3O_4 nanosheets and the improved supercapacitive behaviors is reported. By optimizing the experimental parameters, we achieved a specific capacitance of ~1016.4 F g^(-1) for the Co_3O_4/rGO/NF(nickel foam) system at a current density of 1 A g^(-1). However, the Co_3O_4/NF structure without rGO only delivers a specific capacitance of ~520.0 F g^(-1)at the same current density. The stability test demonstrates that Co_3O_4/rGO/NF retains ~95.5% of the initial capacitance value even after 3000 charge–discharge cycles at a high current density of 7 A g^(-1). Further investigation reveals that capacitance improvement for the Co_3O_4/rGO/NF structure is mainly because of a higher specific surface area(~87.8 m^2g^(-1))and a more optimal mesoporous size(4–15 nm) compared to the corresponding values of 67.1 m^2g^(-1) and 6–25 nm,respectively, for the Co_3O_4/NF structure. rGO and the thinner Co_3O_4 nanosheets benefit from the strain relaxation during the charge and discharge processes, improving the cycling stability of Co_3O_4/rGO/NF. | Tinghui Yao Xin Guo Shengchun Qin Fangyuan Xia Qun Li Yali Li Qiang Chen Junshuai Li Deyan He | 2017 | Nano-Micro Letters2017，9，4： | 8 |
| 4 | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery显示文摘尽管有高 echogenicity 的充满气体的 microbubbles 是广泛地应用的 inclinical ultrasonography,微米规模粒子尺寸在稳固的肿瘤的处理阻碍他们的使用,它对目标可存取不到几百纳米。我们此处建议包含导致 apH 的核心壳 micelle-to-vesicle 转变准备拥有多重特征的超声敏感的聚合 nanospheres (在结构的 polymersomes ) 的一条不平常的途径,包括进水的腔的一个阶段过渡的成像代理人的 nanosize, monodispersity,和加入。这些特征不经由为 polymersome 准备的常规双乳剂方法是可完成的。nanospheres 与双 pH 敏感基于新奇 triblock 共聚物被构造。外部低频率的超声导致的成像代理人的 liquid-to-gas 阶段转变可以为一个快速的药版本破坏 nanospheres,与在一个肿瘤内的同时的渗透织物的药交货。这些效果可以为有效癌症治疗的发展向新机会提供很少不利效果。 | Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai | 2018 | Nano Research2018，11，7： | 3 |
| 5 | Winter wheat grain yield associated with precipitation distribution under long-term nitrogen fertilization in the semiarid Loess Plateau in China显示文摘 | Shengli Guo Hanhua Zhu Tinghui Dang Jinshui Wu Wenzhao Liu Mingde Hao Yong Li J. Keith Syers | 2012 | Geoderma2012，，： | 2 |
| 6 | Enhancement of strength-ductility balance of heavy Ti and Al alloyed FeCoNiCr high-entropy alloys via boron doping显示文摘As one of the most effective mechanisms,precipitation-hardening is widely used to strengthen high-entropy alloys.Yet,heavy precipitation-hardened high-entropy alloys usually exhibit serious embrittlement.How to effectively achieve ultra-high strength and maintain reliable ductility remains a challenge.Here,we report a study of doping extremely little boron to meet this target.We found that adding of 30 ppm boron into the heavy Ti and Al alloyed FCC FeCoNiCr high-entropy,(FeCoNiCr)_(88) Ti_(6) Al_(6) HEA(at.%)which is strengthened mainly by both coarse BCC-based(Ni,Co)_(2) TiAl Heusler and fine L12-type FCC-based(Ni,Co)_(3) TiAl precipitates and shows ultrahigh strength but poor ductility,could significantly change the original microstructure and consequently improve mechanical performance,owing to the well-known effect of boron on reducing the energy of grain boundaries.The boron addition can(1)eliminate microcavities formed at Heusler precipitate-matrix interfaces;(2)suppress the formation and segregation of coarse BCC Heusler precipitates;(3)promote the formation of L12 nanoparticles.This changes of microstructure substantially improve the tensile ductility more than by~86%and retain comparable or even better ultimate tensile strength.These findings may provide a simple and costless solution to produce heavy precipitation-strengthened HEAs with ultrahigh strength and prevent accidental brittleness. | Yongliang Qi Tinghui Cao Hongxiang Zong Yake Wu Lin He Xiangdong Ding Feng Jiang Shenbao Jin Gang Sha Jun Sun | 2021 | Journal of Materials Science & Technology2021，，16： | 2 |
| 7 | Effect Of membrane materials and average pore sizes On reverse osmosis separation Of dyes显示文摘 | LIU Tinghui Matsuura T Sourirajon S | 1983 | Industrial & Engineering Chemistry Product Research and Development1983，22，1： | 1 |
| 8 | Simultaneous estimation of system and input parameters from output measurements显示文摘 | Jones N P Ellis J H | 2000 | Journal of Engrg Mech ASCE2000，126，7： | 1 |
| 9 | Soil water dynamics and deep soil recharge in a recordwet year in the southern Loess Plateau of China显示文摘 | Liu Wenzhao Zhang Xingchang Dang Tinghui | 2010 | Ag-riculture Water Management2010，97，8： | 1 |
| 10 | Factors Influencing Bacterial Canker Disease of Kiwifruit and the Control Countermeasures显示文摘Survey was conducted to investigate the occurrence laws of bacterial canker disease of kiwifruits in Liupanshui area,Guizhou Province,and the pathogens and hazard symptoms of the canker disease were introduced. The results showed that the factors influencing the occurrence of bacterial canker disease of kiwifruit were identified as inter-species resistance,agronomic traits,meteorological and ecological conditions,cultivation and management techniques and fertilization levels. Techniques for the comprehensive control of kiwi canker disease were stated,and control suggestions were proposed. | Kai YAN Jiahui MA Jinli WANG Tinghui WU Rongmao HUANG | 2018 | Agricultural Biotechnology2018，7，1： | 1 |
| 11 | Preliminary experience on treatment of infantile hemangioma with low-dose propranolol in China显示文摘 | Xiaorong Ma Tinghui Zhao Yan Xiao | 2013 | Eur J Pediatr2013，172，： | 1 |
| 12 | Synthesis of N- (2-chloro4-bromo-6-iodophenyl) -maleimide 显示文摘 | Pan Pengcheng Lu Chunfei Cai Tinghui | 1990 | Shanghai Keji Daxue Xuebao1990，13，： | 1 |
| 13 | Influence of aortic branch arteries on the hemodynamics of patient-specific type B aortic dissection following TEVAR显示文摘Objective:Because of the difficulty in obtaining patient specific flow data,branch arteries are often neglected in the flow simulations of a patient-specific type B aortic dissection(AD)following thoracic endovascular repair(TEVAR).This study aims to investigate the influence of the aortic branch arteries on the hemodynamics and physical flow phenomena commonly associated with aortic modeling of an AD after TEVAR.Methods:The three-dimensional geometry of a type B AD following TEVAR was generated from a high-quality CT dataset.Simulations were performed with all branch arteries,without the four visceral arteries of the abdominal aorta(FVAoAA),and without the upper three branches of the aortic arch(UTBoAA).Results:The removal of the UTBoAA has marginal effect on the flow patterns and hemodynamic parameters in the false lumen(FL);however,regardless of whether there are aorta branches supplied to the FL or not,the omission of FVAoAA will result in a wrong prediction of the flow direction at tears and flow volume to the FL.Conclusions:The omission of aorta branch arteries has great impact on the hemodynamic prediction including flow field and wall shear stress related parameters in a type B AD after TEVAR,which may induce misleading estimates of the potential thrombus in the FL.It is strongly recommended to keep aorta branches in the computational model to predict the post-operative hemodynamic performance in a type B AD following TEVAR. | Yi Jiang Yue Qiu Da Li Ding Yuan Tinghui Zheng Liqing Peng | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 14 | Responses of Soil Bacterial Diversity to Fertilization are Driven by Local Environmental Context Across China显示文摘Soil microbial diversity is extremely vulnerable to fertilization,which is one of the main anthropogenic activities associated with global changes.Yet we know little about how and why soil microbial diversity responds to fertilization across contrasting local ecological contexts.This knowledge is fundamental for predicting changes in soil microbial diversity in response to ongoing global changes.We analyzed soils from ten 20-year field fertilization(organic and/or inorganic)experiments across China and found that the national-scale responses of soil bacterial diversity to fertilization are dependent on ecological context.In acidic soils from regions with high precipitation and soil fertility,inorganic fertilization can result in further acidification,resulting in negative impacts on soil bacterial diversity.In comparison,organic fer-tilization causes a smaller disturbance to soil bacterial diversity.Despite the overall role of environmental contexts in driving soil microbial diversity,a small group of bacterial taxa were found to respond to fer-tilization in a consistent way across contrasting regions throughout China.Taxa such as Nitrosospira and Nitrososphaera,which benefit from nitrogen fertilizer addition,as well as Chitinophagaceae,Bacilli,and phototrophic bacteria,which respond positively to organic fertilization,could be used as bioindicators for soil fertility in response to fertilization at the national scale.Overall,our work provides new insights into the importance of local environmental context in determining the responses of soil microbial diver-sity to fertilization,and identifies regions with acidic soils wherein soil microbial diversity is more vul-nerable to fertilization at the national scale. | Youzhi Feng Manuel Delgado-Baquerizo Yongguan Zhu Xiaozeng Han Xiaori Han Xiuli Xin Wei Li Zhibing Guo Tinghui Dang Chenhua Li Bo Zhu Zejiang Cai Daming Li Jiabao Zhang | 2022 | Engineering2022，8，5： | 1 |
| 15 | Effect of increased fertilizer applications to wheat crop on soil-water depletion in the Loess Plateau, China显示文摘 | Mingbin Huang Tinghui Dang Jacques Gallichand Monique Goulet | 2002 | Agricultural Water Management2002，，3： | 1 |
| 16 | Nickel Electrodeposition Studies for High - Aspect - Ratio Microstructure Fabrication for MEMS显示文摘 | Tinghui Xin Pratul K Ajmera | 2006 | Proceedings of SPIE2006，，： | 1 |
| 17 | Purification and separation of single- walled carbon nanotubes (SWCNTs) 显示文摘 | Sun Tinghui | 2012 | Journal of Nanoscience and Nanotechnology2012，12，4： | 1 |
| 18 | Classification of Oxfordshire community stroke project assisted by transcranial Doppler ultrasound examination for treating acute cerebral infarction显示文摘BACKGROUND: The early correct diagnosis of acute cerebral infarction (ACI) is very important for choosing therapeutic regimen. The classification of Oxfordshire community stroke project (OCSP) provides guide for easy and rapid diagnosis and choosing therapeutic regimen in clinical practice. But current operation is not satisfied. Only depending on clinical symptoms and body signs do objective evidences lack. Transcranial Doppler ultrasound (TCD) examination may provide hemodynamical evidences for the correct classification of OCSP to some extent. OBJECTIVE: To compare the results of OCSP classification and TCD examination for treating ACI in patients, and analyze the relationship between them as well as the effect of TCD on the correct classification of OCSP. DESIGN: Controlled observation. SETTING: Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease. PARTICIPANTS: Thirty-eight inpatients with ACI including 21 males and 17 females, aged 50 to 81 years, who received treatment in the Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease within 24 hours after onset from October 2002 to October 2005 were involved. The involved inpatients all confirmed to the diagnostic criteria of ACI formulated in the 4th National Cerebrovascular Diseases Conference. All the cases received skull computer tomography (CT) or magnetic resonance imaging (MRI) examinations at 24 hours after onset. Those patients who had no obvious infarct focus in skull CT examination within 24 hours after onset were performed re-examination to verify ACI within 72 hours after onset. Informed consents of examination method were obtained from all the patients. METHODS: According to the classification of OCSP, the patients were assigned into 4 subtypes: lacunar infarction (LACI), total anterior circulation infarction (TACI), part anterior circulation infarction (PACI) and posterior circulation infarction (POCI). The mean velocity of blood flow of bilateral middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), vertebral artery (VA) and basal artery (BA) were routinely detected through temporal window and occipital window respectively by using 2 MHz detecting head of transcranial Doppler (BMS-9000, USA) at 24 hours after onset. The rate of abnormal velocity of blood flow in each vessel of each type was calculated. The normal velocity of blood flow diagnosed by TCD was 45-75 cm/s in MCA,40-65 cm/s in ACA,30-50 cm/s in PCA,25-45 cm/s in BA and 20-35 cm/s in VA. MAIN OUTCOME MEASURES: TCD examination results of different OSCP classification in patients. RESULTS: In the group of TACI, the signal of blood flow could not be detected in 3 vessels of MCA and 1 vessel of ACA. The sequence of percentage of abnormality of the mean velocity of blood flow was MCA (100%),ACA (85.7%),PCA (71.4%),VA (62.5%)and BA (57.5%). In the group of PACI, the signal of blood flow could not be detected in 3 vessels of ACA, and sequence of percentage of abnormality of the mean velocity of blood flow was MCA (90.9%), ACA (72.7%), BA (53.8%), VA (46.1%) and PCA (45.5%). In the group of POCI, the signal of blood flow could not be detected in 2 vessels of VA and 1 vessel of BA, and the sequence of percentage of abnormality of the mean velocity of blood flow was PCA and BA (100%), VA (80%), MCA (75%) and ACA(62.5%). In the group of LACI, the signal of blood flow could be detected in all the vessels , and the sequence of percentage of abnormality of the mean velocity of blood flow was MCA (63.6%), ACA (54.5%), BA(50%), VA (33.3%) and PCA (31.8%). CONCLUSION: ① Four subtypes of OSCP have characteristic differences, which reflect the main vessels affected by the abnormality of hemodynamics of each subtype, in detecting ACI with TCD examiniation. ② Early TCD examination of ACI in patients has certain reference value for assisting the classification of OCSP. | Xiaohua Xiao Jie Situ Tinghui Li Shaohong Qiu | 2006 | Neural Regeneration Research2006，1，5： | 1 |
| 19 | Effect of membrane materials and average pore sizes on reverse osmosis separation of dyes 显示文摘 | Liu Tinghui Takeshi Matsuura S Sourirajan | 1983 | Industrial &Engineering Chemistry Product Research and Development1983，22，1： | 1 |
| 20 | Propranolol enhanced adipogenesis instead of induction of apoptosis of hemanginmas stem cells 显示文摘 | Ma Xiaorong Zhao Tinghui Ouyang Tianxiang | 2014 | Int J Clin Exp Pathol2014，7，7： | 1 |
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