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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Spatial concentration,congener profiles and inhalation risk assessment of PCDD/Fs and PCBs in the atmosphere of Tianjin,China显示文摘Polychlorinated dibenzo-p-dioxins/dibenzofurans(PCDD/Fs) and polychlorinated biphenyls(PCBs) were monitored in a seasonal passive sampling scheme during June 2008 and January 2009 to investigate the spatial concentration,congener profiles and evaluate the potential inhalation risk in different functional areas in Tianjin,China.The spatial air concentrations and I-TEQs ranged 1.08×102-8.19×10 3 fg m-3(average 2.63×103 fg m-3) and 4.08-325 fg I-TEQ m-3(average 91.4 fg I-TEQ m-3) respectively for PCDD/Fs.The concentration and I-TEQs of PCBs were 3.08×104-3.01×105 fg m-3(average 1.39×105 fg m-3) and 1.72-49.6 fg I-TEQ m-3(average 18.5 fg I-TEQ m-3).It is obvious that PCB concentrations were several hundred times higher than the PCDD/Fs.However,the ambient air PCDD/Fs contributed a major part to the total toxicity equivalents,varying from 72.7% to 89.0%(average 81.8%).The atmospheric PCDD/F levels were observed to be higher in winter for most of sampling sites in the downtown.Besides,inhalation risk assessment showed that local residents might suffer more risk near the point sources than those in living area,industrial zones and background area in Tianjin City.However,the total daily dioxin intake was approximately several to hundreds of times lower than the WHO criteria,showing relatively low exposure risks from the impact of industry point sources in Tianjin City. | DING Lei LI YingMing WANG Pu LI XiaoMin ZHAO ZongShan RUAN Ting ZHANG QingHua | 2013 | Chinese Science Bulletin2013，58，9： | 17 |
| 3 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 4 | Seasonal trend of ambient PCDD/Fs in Tianjin City, northern China using active sampling strategy显示文摘The spatial concentrations, seasonal trends, profiles and congener pairs of ambient polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were investigated within a seasonally active sampling scheme during Jun 2008 and Jan 2009 in Tianjin City, northern China. The PCDD/F concentrations ranged 14.2-172 fg I-TEQ/m3 (average 69.3 fg I-TEQ/m3 ) in summer and (89.8-1.01)×103 fg I-TEQ/m3 (average 509 fg I-TEQ/m3 ) in winter, respectively, except for the E-waste dismantling site where much higher values were observed (1.04×103 fg I-TEQ/m3 in summer and 7.123×103 fg I-TEQ/m3 in winter). The results indicated a significantly seasonal trend with higher TEQ values in winter as compared with summer, which could be related to increased emission sources and seasonal variations of the atmospheric boundary layer height. 2,3,4,7,8-PeCDF was the dominant contributor to the total PCDD/F toxic equivalents, and 2,3,7,8-TCDD was detected at almost all the sampling sites in winter. Most of the similarly substituted PCDD/F congener pairs exhibited high correlations, suggesting that they might have similar environmental fate or sources. But different seasonal and spatial distributions of PCDD/F concentrations indicated that the emission sources might be intermittent. | Lei Ding Yingming Li Pu Wang Xiaomin Li Zongshan Zhao Qinghua Zhang Ting Tuan Guibin Jiang | 2012 | Journal of Environmental Sciences2012，24，11： | 16 |
| 5 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 6 | Origin of Tafoni in the Late Cretaceous Aeolian Sandstones,Danxiashan UNESCO Global Geopark,South China显示文摘Tafoni occur generally in granular rocks around the world, but their origin remains controversial. In this study,the roles of lithology, micro–climate, and organism in tafoni development are investigated in the Danxiashan UNESCO Global Geopark of South China. The Jinshiyan Temple and Luyitang sites along the Jinjiang River are chosen to conduct tafoni morphometry, bedrock petrography, and micro–climate analyses. The research methods used in this study include field observations and measurements, Voronoi diagrams, polarizing microscopic and scanning electron microscopic(SEM)image analysis, and meteorological detection. The tafoni are mostly 2–10 cm in length and elliptical in shape. The Late Cretaceous Jinshiyan sandstones are characterized by a grain–to–grain contact fabric and moderate sorting with a high proportion of soluble grains and cements. The Voronoi diagrams developed through the Arc GIS software are largely consistent with the tafoni openings. Moreover, owing to exposure to solar insolation, the external temperature values are higher than the internal ones, while the external relative humidity values are lower than the internal ones. Therefore, the permeable Jinshiyan sandstones are fundamental for tafoni development, while the abundant moisture from the Jinjiang River and frequent rains is favorable for salt weathering in tandem with biological activities. At last, a five–stage development model is proposed for the tafoni progression in the study area. | CHEN Liuqin GUO Fusheng LIU Fujun XU Huan DING Ting LIU Xin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 13 |
| 7 | 2018: The Hottest Summer in China and Possible Causes显示文摘In 2018,China experienced the hottest summer since 1961.The maximum,mean,and minimum temperatures all reached the highest.Air temperatures in most regions were much higher than normal;in northern China especially,the temperature anomalies were above double of the standard deviations.Consistent variations of temperature anomalies appeared in the national mean and in northern China on different timescales from intraseasonal to annual,indicating that the above normal temperature in northern China contributed significantly to the record-breaking hot summer of entire China.Relationships among the high temperature in summer 2018,the tropospheric circulation,and the global sea surface temperatures(SSTs)are further analyzed.It is found that the intensified and more northward western Pacific subtropical high(WPSH),weakened Northeast China cold vortex(NECV),and positive geopotential height anomaly from northern China to the Sea of Japan resulted in the abnormally high temperature in summer 2018.From late July to mid August,the WPSH was stronger than normal,with its ridge line jumping to north of 40°N;meanwhile,the NECV was much weaker and more northward than normal;both of the two systems led to the persistent high temperature in northern China during this period.In addition,the SSTs in Kuroshio and its extension area(K–KE)in summer 2018 were also the highest since 1961 and the greatest positive SST anomaly in K–KE was favorable for the above normal geopotential height over North China–Northeast China–Japan at 500 hPa,giving rise to the exceptionally high temperature in northern China. | Ting DING Yuan YUAN Jianming ZHANG Hui GAO | 2019 | Journal of Meteorological Research2019，33，4： | 13 |
| 8 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 9 | Characteristics and Changes of Cold Surge Events over China during 1960-2007显示文摘This paper demonstrates regional characteristics, a long-term decreasing trend, and decadal variations in the frequency of cold surge events based on daily mean temperature and daily minimum temperature data in China's Mainland from 1960 to 2008. During these 48 years four high frequency centers of cold surge events were located in Xinjiang, central North China, northeast China, and southeast China. A main frequency peak of cold surge events occurs in autumn for the four regions and another peak is detected in spring over northeast China and southeast China. The regional pattern of cold surge frequencies is in accordance with the perturbation kinetic energy distribution in October December, January, and February April. The long-term decreasing trend ( 0.2 times/decade) of cold surge frequencies in northeast China and decadal variations in China are related to the variations of the temperature difference between southern and northern China in the winter monsoon season; these variations are due to the significant rising of winter temperatures in high latitudes. | DING Ting QIAN Wei-Hong YAN Zhong-Wei | 2009 | Atmospheric and Oceanic Science Letters2009，2，6： | 11 |
| 10 | Preparation of high-affinity rabbit monoclonal antibodies for ciprofloxacin and development of an indirect competitive ELISA for residues in milk显示文摘A convenient competitive enzyme-linked immunosorbent assay(ELISA) for ciprofloxacin(CPFX) was developed by using rabbit monoclonal antibodies(RabMAbs) against a hapten-protein conjugate of CPFX-bovine serum albumin(BSA).The indirect competitive ELISA of CPFX had a concentration at 50% inhibition(IC50) of 1.47 ng/ml and a limit of detection(LOD) of 0.095 ng/ml.The mAb exhibited some cross-reactivity,however,not so high with enrofloxacin(28.8%),ofloxacin(13.1%),norfloxacin(11.0%),fleroxacin(22.6%),and pefloxacin(20.4%).And it showed almost no cross-reactivity with other antibiotics or sulfonamides evaluated in this study.The competitive ELISA kit developed here could be used as a screening tool to detect and control illegal addition of CPFX in food products.This kit had been applied to milk detection and the recovery rates from samples spiked by CPFX were in a range of 63.02%-84.60%,with coefficients of variation of less than 12.2%. | Bin HUANG Yun YIN Lei LU Hai DING Lin WANG Ting YU Jia-jin ZHU Xiao-dong ZHENG Yan-zhen ZHANG | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，10： | 11 |
| 11 | IDENTIFICATION OF MYCOBACTERIUM MARINUM 65 KD HEAT SHOCK PROTEIN GENE BY POLYMERASE CHAIN REACTION RESTRICTION ANALYSIS FROM LESIONS OF SWIMMING POOL GRANULOMA显示文摘Background Nontuberculous mycobacterium (NTM) had been reported to cause cutaneous infections which are difficult to interpret due to the variability of the clinical manifestations. Among NTM infections, Mycobacterium marinum (M. marinum) are mostly seen to cause skin infection. It is therefore important to establish a rapid approach for detection and identification of M. marinum from lesions of patients with suspected M. marinum infections. Methods Specimens were obtained from 5 patients with swimming pool granuloma. DNA was extracted and polymerase chain reaction (PCR) was performed. PCR products were digested with Hae III and BstE II, then analysed by pattern restriction analysis to detect heat shock protein (hsp) 65 kD gene. Results The 65 kD hsp gene was found in all specimens from patients with swimming pool granuloma. PCR restriction analysis (PRA) identified all 5 samples to be M. marinum infections, and the result was consistent with that of routine bacteriological identification. The lesions subsided or markedly improved upon treatment. Conclusions PRA is a sensitive, specific and rapid method in identification of mycobacteria. Application of this method will be helpful for early diagnosis of mycobacterial skin infections. | CAI Lin CHEN Xue ZHAO Ting DING Bei-chuan ZHANG Jian-zhong | 2006 | Chinese Medical Journal2006，，1： | 11 |
| 12 | A new multi-wavelength solar telescope: Optical and Near-infrared Solar Eruption Tracer (ONSET)显示文摘A new multi-wavelength solar telescope,the Optical and Near-infrared Solar Eruption Tracer(ONSET)of Nanjing University,has been constructed.It was fabricated at the Nanjing Institute of Astronomical Optics&Technology,and the operation is jointly administered with Yunnan Astronomical Observatory.ONSET is able to observe the Sun in three wavelength windows:He I 10830?A,Hαand white-light at3600?A and 4250?A,which are selected in order to simultaneously record the dynamics of the corona,chromosphere and photosphere respectively.Full-disk or partial-disk solar images with a field of 10 at three wavelengths can be obtained nearly simultaneously.It is designed to trace solar eruptions with high spatial and temporal resolutions.This telescope was installed at a new solar observing site near Fuxian Lake in Yunnan Province,southwest China.The site is located at E102N24,with an altitude of 1722 m.The seeing is stable and has high quality.We give a brief description of the scientific objectives and the basic structure of ONSET.Some preliminary results are also presented. | Cheng Fang Peng-Fei Chen Zhen Li Ming-De Ding Yu Dai Xiao-Yu Zhang Wei-Jun Mao Jun-Ping Zhang Ting Li Yong-Jun Liang Hai-Tian Lu | 2013 | Research in Astronomy and Astrophysics2013，13，12： | 9 |
| 13 | Analysis of reference gene expression for real-time PCR based on relative quantitation and dual spike-in strategy in the silkworm Bombyx mori显示文摘为即时量的聚合酶链反应(qPCR ) ,一般来说,正规化策略把引用基因用作控制并且不应该响应改变条件变化避免这基因的试验性的错误表示的介绍。然而,许多参考基因的表示被报导了更加变化,没有适当正规化,目标基因的表示侧面能被曲解。在这研究,七的表达式层次通常使用了引用基因(行为, GAPDH, 28srRNA, RPL3, -tubulin, UBC,和 TBP ) 与 20-hydroxyecdysone (20E ) 并且与卢丁在不同开发时间点并且响应处理被检测。表示稳定性用 geNorm 和 NormFinder 软件被分析。重要变化在正常纸巾之中并且在试验性地对待的纸巾之间被发现。双刺在里面策略也在正常纸巾之中并且在试验性地对待的纸巾之间揭示了参考基因的表示层次的重要变化。Glutathione-S-transferase 西格马 1 (GSTs1 ) ,它在胖身体有高表达式水平并且与抵抗的机制有关,被用作目标基因验证这二条途径的可行性和差别。 | Ran Peng Yuanfen Zhai Hua Ding Tianyuan Di Ting Zhang Bing Li Weide Shen Zhengguo Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 8 |
| 14 | Capsule endoscopy and single-balloon enteroscopy in small bowel diseases: Competing or complementary?显示文摘AIM To evaluate diagnostic yields of capsule endoscopy(CE) and/or single-balloon enteroscopy(SBE) in patients with suspected small bowel diseases.METHODS Were trospectively analyzed 700 patients with suspected small bowel diseases from September 2010 to March 2016. CE, SBE, or SBE with prior CE was performed in 401, 353, and 47 patients, respectively. Data from clinical and endoscopy records were collected for analysis. Indications, procedure times, diagnostic yields, and complications were summarized and evaluated.RESULTS The overall diagnostic yield for the CE group was 57.6%. The diagnostic yield of CE in patients with obscure gastroin testinal bleeding(OGIB) was significantly greater than that in patients with no bleeding(70.5% vs 43.8%, P < 0.01). The overall diagnostic yield of SBE was 69.7%. There was no difference in the diagnostic yield of SBE between patients with OGIB and those with no bleeding(72.5% vs 68.9%, P = 0.534). Forty-seven patients underwent CE prior to SBE. Among them, the diagnostic yield of SBE with positive findings on prior CE was 93.3%. In addition, SBE detected two cases with superficial ulcer and erosive lesions in the small bowel, which were missed by CE. However, one case with lymphoma and two with Crohn's disease were not confirmed by SBE. The rate of capsule retention was 2.0%. There were no significant complications during or after SBE examinations.CONCLUSION SBE is a safe and effective technique for diagnosing small bowel diseases. SBE with prior CE seemed to improve the diagnostic yield of small bowel diseases. | Jing-Jing Ma Ying Wang Xiao-Min Xu Jie-Wen Su Wen-Yu Jiang Jian-Xia Jiang Lin Lin Dao-Quan Zhang Jing Ding Li Chen Ting Jiang Ying-Hong Xu Gui Tao Hong-Jie Zhang | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 15 | Structural Evolution and Hydrocarbon Potential of the Upper Paleozoic Northern Ordos Basin, North China显示文摘在北 Ordos 盆的 Hangjinqi 区域的烃潜力不是众所周知的,与盆的另外的区域相比,尽管有它的实质的石油系统。越过在东方 Hangjinqi 区域的 Hangjinqi 差错地区( HFZ )的变换深度的地震侧面的恢复显示出创造了背斜的结构在的一压缩晚三叠纪,并且在 ∼Middle 侏罗记的二延期和晚早的白垩纪,它被倒置分别地在晚侏罗记早的早白垩纪和迟了的白垩纪打断。在在中央 Ordos 盆(圆块) 的井地点的烃产生开始了在晚三叠纪。盆当模特儿井 Zhao-4 从北 Shanbei 斜坡的迟了的含碳早二叠的煤措施建议那烃代在早白垩纪达到顶点,在迟了的白垩纪早于倒置。在 Shanbei 斜坡的大多数来源岩石除了 Hangjinqi 区域来源岩石(井 Jin-48 ) 传递了主要煤气迁居的阶段。因为盆充满阶层向南正在蘸,从 COB 产生的烃是可能的沿着 HFZ 向背斜的结构和陷井向北方移植了。指责在 Hangjinqi 区域的 extensional 阶段(晚早的白垩纪) 期间继续那可能为烃的迁居充当了水管。因此,到 HFZ 的北方的背斜的结构和联系陷井可能套住自从中间的侏罗记,在 COB 从迟了的含碳早二叠的煤措施被控告的烃。 | YANG Minghui LI Liang ZHOU Jin JIA Huichong SUN Xiao GONG Ting DING Chao | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 7 |
| 16 | The Record-Breaking Extreme Drought in Yunnan Province, Southwest China during Spring-Early Summer of 2019 and Possible Causes显示文摘In spring and early summer of 2019, Yunnan Province experienced the most severe seasonal drought on record,with days of extreme drought area exceeding 10^5 km^2 far more than normal. Consistently, the precipitation in each month from February to June is over 30% less than normal, and about 50% less in the most severe drought period(April–June). The rainy season in Southwest China(SWC) started on the third pentad in June 2019, which is the second latest in history. The rainy season in Yunnan started on 24 June, which is the latest(29 days later than normal). On the contrary, the onset of the South China Sea summer monsoon(SCSSM) is abnormally early. The lag time between the start of the rainy season in SWC and the onset of the SCSSM in 2019 is 7 pentads, which is the largest since 1961, much longer than the climate mean(less than 1 pentad). The present study analyzes the possible reasons why the rainy season came extremely late and the drought disaster persisted and intensified after a much early SCSSM, at both seasonal and subseasonal timescales. The abnormally late onset of the rainy season and the second greatest potential evapotranspiration(PET) since 1981 are the direct reasons for the persistent drought. Statistical results show that the water vapor from southwest of Yunnan in April–June contributes more than that from the east at the seasonal scale. In April–June 2019, however, the southern branch trough(SBT) was abnormally weak, the large and strong anticyclonic wind anomaly prevailed over the Bay of the Bengal(BOB), and the meridional water vapor transport to Yunnan was weak. At the subseasonal scale, the weaker SBT lasted the longest, and the strong convection over the BOB came up late despite of an early onset of the SCSSM, which resulted in reduced low-level moisture convergence in Yunnan and development of drought prior to the SCSSM onset. From the onset of SCSSM to the start of rainy season in SWC, the SBT and meridional water vapor transport from the BOB were still weak, and the water vapor was mainly transported into the coastal area of South and Southeast China rather than Yunnan. After the start of the rainy season in SWC, the SBT was still weak. This led to less moisture transport in the westerlies to the west of Yunnan and the persistent extreme drought. Both the statistical results and case analysis indicate that the stronger Australian high in spring and early summer of 2019 was associated with the abnormally strong anticyclone over the BOB and the always weak SBT. In sum, the anomalous weakness of SBT played a critical role in the extreme drought occurrence and persistence in Yunnan of Southwest China in 2019. | Ting DING Hui GAO | 2020 | Journal of Meteorological Research2020，34，5： | 7 |
| 17 | Characteristics of the phytoplankton community and bioaccumulation of heavy metals during algal blooms in Xiangjiang River (Hunan,China)显示文摘The frequency of algal blooms has increased in the mid and downstream reaches of the Xiangjiang River (Hunan,China),one of the most heavily polluted rivers in China.We identified the bloom-forming species in a bloom that occurred mid-late September 2010.In addition,we determined the extent of metal bioaccumulation in the algae and measured the toxicity of the algae using a mouse bioassay.Water samples were collected at upstream (Yongzhou),midstream (Hengyang),and downstream (Zhuzhou,Xiangtan,and Changsha) sites.The dominant species was Aulacoseira granulata,formerly known as Melosira granulata.The heaviest bloom occurred at Xiangtan and Changsha,where the number of A.granulata peaked at 1.3×10 5 filaments L 1 and chlorophyll a at 0.04 mg L 1.Concentrations of Al,Fe,and Mn were 4.4 10 3,768.4,and 138.7 mg kg 1 dry weight in the phytoplankton.The bioaccumulation factor was 4.0×10 5,7.7×10 5,and 3.2×10 3,respectively.The heavy metal Pb had the greatest tendency to bioaccumulate among the highly toxic heavy metals,with a concentration of 19.2 mg kg 1 dry weight and bioaccumulation factor of 9.6×10 3.The mouse bioassay suggested the bloom was toxic.The LD 50 was 384 mg kg 1 and all surviving mice lost weight during the first 72 h after exposure.Our results demonstrate that blooms of A.granulata in rivers contaminated with heavy metals pose a threat to freshwater ecosystems and human health.Thus,measures should be taken to control eutrophication and heavy metal pollution in such rivers. | LI Jie PENG FuLi DING DongBo ZHANG ShuBing LI DeLiang ZHANG Ting | 2011 | Science China(Life Sciences)2011，54，10： | 6 |
| 18 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 19 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 20 | First-principles study on electronic structure and optical properties of N-doped P-type β-Ga_2O_3显示文摘The band structure, density of states, electron density difference and optical properties of intrinsic β-Ga2O3 and N-doped β-Ga2O3 were calculated using first-principles based on density functional theory. After N doping, the band gap decreases, shallow acceptor impurity levels are introduced over the top of the valence band and the absorption band edge is slightly red-shifted compared to that of the intrinsic one. The anisotropic optical properties are investigated by means of the complex dielectric function, which are explained by the selection rule of the band-to-band transitions. All calculation results indicate that N-doping is a very promising method to get P-type β-Ga2O3. | ZHANG LiYing YAN JinLiang ZHANG YiJun LI Ting DING XingWei | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，1： | 5 |
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