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| 1 | U-series chronology of lacustrine deposits in Death Valley, California显示文摘 | Ku T L Luo S D Tim K L | 1998 | Quaternary research1998，50，： | 1 |
| 2 | Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments:a biomechanical analysis显示文摘 | Akamaru T Kawahara N Tim Yoon S | 2003 | Spine2003，28，14： | 1 |
| 3 | Biochar adsorbed ammonia is bioavailable显示文摘 | Rezoo T T Tim J C Robert R S | 2012 | Plant Soil2012，350，12： | 1 |
| 4 | The effect of bone morphogenetic protein-2 on rat in- tervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | 2003 | Spine(Phila Pa 1976)2003，28，： | 1 |
| 5 | Mechanics of secondary hydrocarbon migration and entrapment显示文摘 | Tim T S | 1979 | AAPG Bulletin1979，63，5： | 1 |
| 6 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 7 | Adjacent segment mo- tion after a simulated lumbar fusion in different sagittal align- ments: a biomechanical analysis显示文摘 | Akamaru T Kawahara N Tim Y S | 2003 | Spine2003，28，14： | 1 |
| 8 | Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments:a biomechanical analysis显示文摘 | AKAMARU T KAWAHARA N TIM YOON S | 2003 | Spine2003，28，14： | 1 |
| 9 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 10 | BiocharAdsorbed Ammonia Is Bioavailable显示文摘 | Arezoo T T Tim J C Robert R S | 2012 | Plant andSoil2012，350，2： | 1 |
| 11 | Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments:a biomechanical analysis显示文摘 | Akamaru T Kawahara N Tim Yoon S | | 0，，1976： | 1 |
| 12 | Adjacent segment motion after a simulated lumbar fusion in different sagittal align- ments: a biomechanical analysis 显示文摘 | Akamaru T Kawahara N Tim Yoon S | 2003 | Spine (Phila Pa 1976)2003，28，14： | 1 |
| 13 | Arranging place and time: A GIS toolkit to assess person-based accessibility of ur- ban Opportunities显示文摘 | Neutens T Mathias V Tim S | 2010 | Applied Geography2010，30，： | 1 |
| 14 | Adjacent segment motion after a simulated lumbar fusion in different sagittalalignments a bicmechanical analysis显示文摘 | Akamaru T Kawahara N Tim Yoon S | 2003 | Spine2003，28，14： | 1 |
| 15 | Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments:a biomechanical analysis显示文摘 | Akamaru T Kawahara N Tim Yoon S | 2003 | Spine2003，28，14： | 1 |
| 16 | A simple spreadsheet-based,MIAME-supportive format for microarray data:MAGE-TAB显示文摘 | Tim F R Philippe R S Paul T S | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 17 | Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilization of the biofilm structure 显示文摘 | Molin S Tim T N | 2003 | Current Opinion in Biotechnology2003，14，： | 1 |
| 18 | Measuring marketing productivity: current knowledge and future directions显示文摘 | Roland T R Tim A Gregory S C | 2004 | Journal of Marketing2004，68，4： | 1 |
| 19 | The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | | 0，，1976： | 1 |
| 20 | Further evidence of differcences in substance use and dependence between Australia and the United States显示文摘 | Orla M Maree T Tim S | 2009 | Drug Alcohol Depend2009，100，： | 1 |
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