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| 1 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 4 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
| 5 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M?rten Tim Greten Carsten Ziske Sabine Renoth Bj?rn Sch?ttker Peter Buttgereit Frank Schakowski Alexander von Rücker Tilman Sauerbruch Ingo G. Schmidt-Wolf | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 6 | Unconventional shale gas systems:The Mississippian barnett shale of north central Texas as one model for thermogenic shale gas assessment显示文摘 | Jarvie M Ronald J H Tim E R | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 7 | Unconventional shale- gas systems:The Mississippian Barnett Shale of north-central Texas as one model for thermogenic shale-gas assessment显示文摘 | Daniel M J Ronald J H Tim E R et a/ | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 8 | Quantifying elemental sulfur ( SO ), bisulfide ( HS^- ) and polysulfides (Sx^2- ) using a voltammetric method 显示文摘 | Tim F R Theberge S M George Luther Ⅲ | 2000 | Analytica Chimica Acta2000，415，12： | 1 |
| 9 | Unconventional shale- gas systems:The Mississlppian Barnett Shale of north-central Texas as one model for thermogenic shale-gas assessment显示文摘 | Daniel M J Ronald J H Tim E R | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 10 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
| 11 | Unconventional shale gas systems : The Mississippian Barnett shale of north - central Texas as one model for thermogenic shale-gas assessment 显示文摘 | Daniel M J Ronald J H Tim E R | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 12 | Solar thermotherapy reduces the titer of Candidatus Liberibacter asiaticus and enhances canopy growth by altering gene expression profiles in HLB-affected citrus plants显示文摘Huanglongbing(HLB),a systemic and destructive disease of citrus,is associated with‘Candidatus Liberibacter asiaticus’(Las)in the United States.Our earlier work has shown that Las bacteria were significantly reduced or eliminated when potted HLB-affected citrus were continuously exposed to high temperatures of 40 to 42°C for a minimum of 48 h.To determine the feasibility and effectiveness of solar thermotherapy in the field,portable plastic enclosures were placed over commercial and residential citrus,exposing trees to high temperatures through solarization.Within 3–6 weeks after treatment,most trees responded with vigorous new growth.Las titer in new growth was greatly reduced for 18–36 months after treatment.Unlike with potted trees,exposure to high heat did not eradicate the Las population under field conditions.This may be attributed to reduced temperatures at night in the field compared to continuous high temperature exposure that can be maintained in growth chambers,and the failure to achieve therapeutic temperatures in the root zone.Despite the presence of Las in heat-treated commercial citrus,many trees produced abundant flush and grew vigorously for 2 to 3 years after treatment.Transcriptome analysis comparing healthy trees to HLB-affected citrus both before and after heat treatment demonstrated that post-treatment transcriptional expression patterns more closely resembled the expression patterns of healthy controls for most differentially expressed genes and that genes involved with plant-bacterium interactions are upregulated after heat treatment.Overall,these results indicate that solar thermotherapy can be an effective component of an integrated control strategy for citrus HLB. | Melissa M Doud Yungsheng Wang Michelle T Hoffman Christina L Latza Weiqi Luo Cheryl M Armstrong Tim R Gottwald Liangying Dai Feng Luo Yongping Duan | 2017 | Horticulture Research2017，4，1： | 1 |
| 13 | LiDAR Mapping of Canopy Gaps in Continuous Cover Forests : A Comparison of Can- opy Height Model and Point Cloud Based Techniques 显示文摘 | GAULTON R TIM J M | 2010 | International Journal of Remote Sensing2010，31，5： | 1 |
| 14 | Unconventional shale-gas systems: The Mississippian Barnett Shale of north-central Texas as one model for thermogenic shale- gas assessment 显示文摘 | Daniel M J Ronald J H Tim E R | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 15 | Unconventional shale-gas systems: the Mississippian Barnett shale of north central Texas as one model for thermogenic shale-gas assessment 显示文摘 | Daniel M J Ronald J H Tim E R | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 16 | Unconventional shalegas systems: the Mississippian Barnett shale of north-central Texas as one model for thermogenic shale-gas assessment显示文摘 | Daniel M J Ronald J H Tim E R etal | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 17 | Unconventional shale-gas sys- tems:The Mississippian Barnett Shale of north-central Texas as one model for thermogenic shale-gasassessment显示文摘 | Daniel M J Hill R J Tim E R | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 18 | Unconventional shale gas systems: The Mississippian Barnett shale of North Central Texas as one model for thermogenic shale gas assessment显示文摘 | Jarvie M D Hill J R Tim E | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 19 | Effect of carbon to nitrogen ratio of food waste on biogas methane production in a batch mesophilic anaerobic digester显示文摘 | Tanimu M I Ghazi TIM Harun R M | 2014 | International Journal of Innovation Management and Technology2014，2，5： | 1 |
| 20 | Bioehar induced soil microbial community chang: Implications for biogeochemicalcycling of carbon, nitrogen and phosphorus显示文摘 | Craig R Anderson Leo M Condron Tim J Clough | 2011 | Pedobiologia2011，54，： | 1 |
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