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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Associations between particle physicochemical characteristics and oxidative capacity: An indoor PM 10 study in Beijing, China显示文摘 | Longyi Shao Jinjuan Li Houyin Zhao Shushen Yang Hui Li Weijun Li Tim Jones Keith Sexton Kelly BéruBé | 2007 | Atmospheric Environment2007，，26： | 2 |
| 3 | Hemolysis of PM_(10) on RBCs in vitro:An indoor air study in a coal-burning lung cancer epidemic area显示文摘Epidemiological studies have suggested that inhalation exposure to indoor ambient air from coal-burning environments is causally associated with respiratory health risks.In order to explore the toxicological mechanisms behind the adverse health effects,the hemolytic activity of PM_(10)(particulate matter with an aerodynamic diameter of 10 um or less)samples collected from homes burning coal in the recognized China'cancer village'Xuanwei were evaluated and matched against their trace elemental contents.The results demonstrated that the hemolytic activity of indoor PM_(10) in coal-burning environments ranged from 4.28%to 5.24%,with a clear positive dose-response relationship.Although low dose samples exhibited a reduced hemolytic activity,PM_(10) could have a toxic effect upon people in a coal-burning indoor environment for extended time periods.The concentrations of analyzed trace elements in PM_(10) samples ranged from 6966 to 12,958 ppm.Among the analyzed elements,Zn,Ti,Ni,Cu,Pb,Ba,Mn,Cr and V were found at higher concentrations and accounted for over 95%of the total elements.The concentrations of total analyzed elements in the PM_(10) samples revealed a significant positive correlation with PM_(10) hemolytic activity.Of the analyzed elements,Zn,Pb and Cs positively correlated with hemolysis,while Li,U and V negatively correlated with the hemolysis of human red blood cells(RBCs).Therefore,the heavy metal elements could be one of the main factors responsible for the hemolytic capacity of indoor PM_(10) in coal-burning environments. | Mengyuan Zhang Longyi Shao Tim Jones Ying Hu Rachel Adams Kelly BéruBé | 2022 | Geoscience Frontiers2022，13，1： | 2 |
| 4 | Model-Based Assurance for Justifying Automotive Functional Safety 显示文摘 | Ibrahim Habli Ireri Ibarra Roger Rivett Tim Kelly | 2010 | SAE 2010-01-02092010，，： | 1 |
| 5 | Associations between particle physieoohemieal characteristics and oxidative capacity:an indoor PM《,10》 study in Beijing,China显示文摘 | Shao Longyi Jinjuan Li Houyin Zhao Shnshen Yang Hui Li Weijun Li Tim Jones Keith Sexton and Kelly BeruBe | 2007 | Atmospheric Environment2007，41，： | 1 |
| 6 | Elution characteristics of tobramycin from polycaprolatone in a rabbit model显示文摘 | David L Tim A | 2001 | Clin Orthop2001，，394： | 1 |
| 7 | Use of tightrope fixation in ankle syndesmotic injuries显示文摘[摘要] 有螺丝钉的 syndesmotic 损害的 ObjectiveConventional 固定仍然保持有问题。一台新奇 fibrewire 设备(Tightrope®) 建议了优点。然而,小案例系列报导了高软的织物复杂并发症率。我们的学习的目的是确定在病人的复杂并发症率和进一步的过程与钢丝对待。第二等的目的是在与 syndesmotic 对待的那些决定复杂并发症和进一步的过程的发生的 A 在为在 2008 年 5 月和 2009 年 10 月之间的脚关节骨折经历 syndesmotic 固定的一样的 period.MethodsAll 病人上拧紧回顾地被考察。复杂并发症的发生,第二等的过程,在非重量适用上花的 syndesmotic 减小和时间的维护被记录。家庭医生为与钢丝对待检查因为任何复杂并发症管理了 elsewhere.ResultsThirty 的那些被联系 -- 五个病人要求了 syndesmotic 固定, 12 与钢丝在被对待。他们被跟随在上面在为 12.4 的一个平均数的诊所;星期。家庭医生在平均数 14.6 被联系;在治疗以后的月受苦了决定任何复杂并发症。没有对固定的方法可归因的复杂并发症。在这个系列, 12 个病人在分泌物经历了 13 过程和没有耐心的有的周期性的脱离;与螺丝钉固定对待的 23 个病人经历了 45 过程(19 是螺丝钉移动) 。有 syndesmotic 脱离的 1 个盒子。螺丝钉移动导致了 2 次要的 complications.ConclusionTightrope 固定 provideds 在分泌物被维持的有效 syndesmotic 固定。我们不经历复杂并发症在其它地方报导了的软织物。 | Julian Maempel Anthony Ward Tim Chesser Michael Kelly | 2014 | Chinese Journal of Traumatology2014，17，1： | 1 |
| 8 | 促进机器人辅助前列腺癌根治术术后早期尿控恢复的手术技巧(“大家泌尿网”观看手术视频)显示文摘机器人辅助前列腺癌根治术(RARP)目前已经成为局限性有临床意义前列腺癌的根治性治疗的新的金标准。本文介绍了既往研究中通过RAND/UCLA改良法确认和研讨的16项促进RARP术后早期尿控恢复的手术技巧,并对各手术技巧进行了介绍。 | 古迪 王铭 吴祥坤 SRIDHAR Ashwin N RAJAN Prabhakar SOORIAKUMARAN Prasanna SHAW Greg NATHAN Senthil KELLY John D BRIGGS Tim P | 2021 | 现代泌尿外科杂志2021，26，8： | 1 |
| 9 | Supporting systems of systems hazard analysis using multi-agent simulation显示文摘 | Rob Alexander Tim Kelly | 2013 | Safety Science2013，51，1： | 1 |
| 10 | Elution characteristics of tobramycin from polycaprolatone in a rabbit model显示文摘 | Kelly J David L Tim A | 2001 | Clin Orthop2001，，394： | 1 |
| 11 | The role of airborne particles and environmental considerations in the transmission of SARS-CoV-2显示文摘Corona Virus Disease 2019(COVID-19)caused by the novel coronavirus,results in an acute respiratory condition coronavirus 2(SARS-CoV-2)and is highly infectious.The recent spread of this virus has caused a global pandemic.Currently,the transmission routes of SARS-CoV-2 are being established,especially the role of environmental transmission.Here we review the environmental transmission routes and persistence of SARS-CoV-2.Recent studies have established that the transmission of this virus may occur,amongst others,in the air,water,soil,cold-chain,biota,and surface contact.It has also been found that the survival potential of the SARS-CoV-2 virus is dependent on different environmental conditions and pollution.Potentially important pathways include aerosol and fecal matter.Particulate matter may also be a carrier for SARS-CoV-2.Since microscopic particles can be easily absorbed by humans,more attention must be focused on the dissemination of these particles.These considerations are required to evolve a theoretical platform for epidemic control and to minimize the global threat from future epidemics. | Longyi Shao Shuoyi Ge Tim Jones M.Santosh Luis F.O.Silva Yaxin Cao Marcos L.S.Oliveira Mengyuan Zhang Kelly BéruBé | 2021 | Geoscience Frontiers2021，12，5： | 1 |
| 12 | Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling显示文摘The most abundant immunoglobulin present in the human body is IgA. It has the highest concentrations at the mucosal lining and in biofluids such as milk and is the second most abundant class of antibodies in serum. We assessed the structural diversity and clonal repertoire of IgA1-containing molecular assemblies longitudinally in human serum and milk from three donors using a mass spectrometry-based approach. IgA-containing molecules purified from serum or milk were assessed by the release and subsequent analysis of their Fab fragments. Our data revealed that serum IgA1 consists of two distinct structural populations, namely monomeric IgA1 (∼80%) and dimeric joining (J-) chain coupled IgA1 (∼20%). Also, we confirmed that IgA1 in milk is present solely as secretory (S)IgA, consisting of two (∼50%), three (∼33%) or four (∼17%) IgA1 molecules assembled with a J-chain and secretory component (SC). Interestingly, the serum and milk IgA1-Fab repertoires were distinct between monomeric, and J-chain coupled dimeric IgA1. The serum dimeric J-chain coupled IgA1 repertoire contained several abundant clones also observed in the milk IgA1 repertoire. The latter repertoire had little to no overlap with the serum monomeric IgA1 repertoire. This suggests that human IgA1s have (at least) two distinct origins;one of these produces dimeric J-chain coupled IgA1 molecules, shared in human serum and milk, and another produces monomeric IgA1 ending up exclusively in serum. | Kelly A.Dingess Max Hoek Danique M.Hvan Rijswijk Sem Tamara Maurits Aden Boer Tim Veth Mirjam J.A.Damen Arjan Barendregt Michelle Romijn Hannah G.Juncker Britt Jvan Keulen Gestur Vidarsson Johannes Bvan Goudoever Albert Bondt Albert J.R.Heck | 2023 | Cellular & Molecular Immunology2023，20，1： | 0 |
| 13 | 选择正确的市场显示文摘疾病的患病人口统计学和流行病学帮助药厂选择合适的药物市场。 | Tim Kelly Jerry Rosenblatt 张殿增(译) | 2007 | 生物技术世界2007，，3： | 0 |
| 14 | 马自达:福特的试验场显示文摘作为美国第二大汽车制造公司,福特公司正从其控股公司马自达那里获取信息和经营理念。目前,阿兰·穆拉利(Alan Mulally)正四处取经以使陷入困境的福特汽车制造公司走上盈利之路。此前,阿兰·穆拉利以行政总裁的身份前往日本广岛,考察日本汽车制造商马自达公司如何走上复兴之路。 | Tim Kelly 杨光辉(译) CFP(图) | 2007 | 品质2007，，12： | 0 |
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