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16篇 您的检索式：作者名="Tibble JA"

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		题名	作者	年代	出处	被引量
	1	Non-invasive investigation of inflammatory bowel disease显示文摘The assessment of inflammatory activity in intestinal disease in man can be done using a variety of different techniques. These range from the use of non - invasive acute phase inflammatory markers measured in plasma such as C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) (both of which give an indirect assessment of disease activity) to the direct assessment of disease activity by intestinal biopsy performed during endoscopy in association with endoscopic scoring systems. Both radiology and endoscopy are conventional for the diagnosis of inflammatory bowel disease (IBD).However these techniques have severe limitations when it comes to assessing functional components of the disease such as activity and prognosis. Here we briefly review the value of two emerging intestinal function tests. Intestinal permeability, although ideally suited for diagnostic screening for small bowel Crohns disease, appears to give reliable predictive data for imminent relapse of small bowel Crohns disease and it can be used to assess responses to treatment. More significantly it is now clear that single stool assay of neutrophil specific proteins (calprotectin, lactoferrin) give the same quantitative data on intestinal inflammation as the 4 - day faecal excretion of 111lndium labelled white cells. Faecal calprotectin is shown to be increased in over 95% of patients with IBD and correlates with clinical disease activity. It reliably differentiates between patients with IBD and irritable bowel syndrome. More importantly, at a given faecal calprotectin concentration in patients with quiescent IBD,the test has a specificity and sensitivity in excess of 85% in predicting clinical relapse of disease. This suggests that relapse of IBD is closely related to the degree of intestinal inflammation and suggests that targeted treatment at an asymptomatic stage of the disease may be indicated.	JA Tibble IBjarnason	2001	World Journal of Gastroenterology2001，7，4：	10
	2	显示文摘	Sigthorsson G Foster R	1999	Gut1999，45，3：	1
	3	Use of surrogate markers of inflammation and Rome criteria to distin guish organic from nonorganic intestinal disease显示文摘	Tibble JA Sigthorsson G Foster R		0，，02：	1
	4	Role of endoscopic endoprostheses in proximal malignant biliary obstruction显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Pan- creat Surg2001，8，2：	1
	5	Role of endoscopic endoprosthes'es in proximal malignant biliary obstruction 显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Panereat Surg2001，8，2：	1
	6	Use of surrogate markers of inflammation and Rome criteria to distinguish or- ganic from nonorganic intestinal disease 显示文摘	Tibble JA Sigthorsson G Foster R	2002	Gastroenterolo- gy2002，123，2：	1
	7	Role of endoscopic endoprostheses in proximal malignant biliary obstruction 显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Pancreat Surg2001，8，2：	1
	8	Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease 显示文摘	Tibble JA Sigthorsson G Bridger S	2000	Gastroenterology2000，119，1：	1
	9	Role of endoscopic endoprostheses in proximal malignantbiliary obstruction显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Pancreat Surg2001，8，2：	1
	10	Role of endoscopic endoprostheses in proximal malignant biliary obstruction 显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Pancreat Surg2001，8，2：	1
	11	Surrogate markers of intestinalinflammation are predictive of relapse in patients with in- flammatory bowel disease 显示文摘	Tibble JA Sigthorsson G Bridger S etal	2000	Gastroenterology2000，119，1：	1
	12	Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease 显示文摘	Tibble JA Sigthorsson G Foster R	2002	Gastroenterology2002，123，2：	1
	13	Role of endoscopic endoprostheses in proximal malignant biliary obstruction显示文摘	TIBBLE JA CAIRNS SR	2001	J Hepatobiliary Pancreat Surg2001，8，2：	1
	14	Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease 显示文摘	Tibble JA Sigthorsson G Bridger S	2000	Gastroenterology2000，119，1：	1
	15	Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease显示文摘	Tibble JA Sigthorsson G Foster R	2002	Gastroenterol2002，123，2：	1
	16	Role of endoscopic endoprostheses in proximal malignant biliary obstruction显示文摘	Tibble JA Cairns SR	2001	J Hepatobiliary Pancreat Surg2001，8，：	1

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