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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Phragmites australis and Typha orientalis in removal of pollutant in Taihu Lake, China显示文摘Two plant populations of Phragmites australis and Typha orientalis grown in gravel and sediment substrate were studied to assess their capabilities for purifying polluted water in Taihu Lake, China. The substrate displayed most significant effects on the suspended matter (P < 0.01), with the reduction of 76%-87% and 52%-63% for P. australis, and 83%-86% and 45%-62% for T. orientalis in gravel substrate and sediment substrate, respectively. Both species and substrates significantly decreased the N and P concentrations of water body (P < 0.01). P. australis showed higher total N and P concentrations in tissues than T. orientalis and had a greater potential to remove nutrients from the lake. Phosphate was easily to concentrate in the belowground tissues, while nitrate concentration was higher in leaf and stalk. Therefore, harvesting the aboveground tissues could take most of nitrate out of the sediment. The saturate photosynthetic rate (Asat) of P. australis was higher than that of T. orientalis when grown in sediment substrate. But instance water-use- effciency (WUEi) (A/E) and intrinsic water use effciency (A/gs) showed the maximum values of two species grown in river water. With significant difference in gs, however, intercellular CO2 concentration (Ci) had no obvious difference in two species which indicated that high Asat value of P. australis might result from the increased carboxylation capacity of the mesophyll, because of the central role of N in photosynthetic enzymes. Our findings suggest that the plants could absorb most of nitrogen in polluted water, while gravel displayed a high capacity for absorbing the suspended matters and phosphate salts. Therefore, biological and physiological pathways for pollutant removal should be integrated. | TIAN Ziqiang ZHENG Binghui LIU Meizhen ZHANG Zhenyu | 2009 | Journal of Environmental Sciences2009，21，4： | 4 |
| 3 | Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli显示文摘 | Guanjun Gao Bing Tian Lili Liu Duohong Sheng Binghui Shen Yuejin Hua | 2003 | DNA Repair2003，，12： | 1 |
| 4 | SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Radl-Husl to counteract DNA replication stress显示文摘 | Xiaoli Xu Rongyi Shi Li Zheng Zhigang Guo Liangyan Wang Mian Zhou Ye Zhao Bing Tian Khue Truong Yuan Chen Binghui Shen Yuejin Hua Hong Xu | 2018 | Journal of Molecular Cell Biology2018，10，5： | 1 |
| 5 | Adsorption of 1,2-dichlorobenzene from water to carbon nanotubes 显示文摘 | Peng Xianjia Li Yanhui Luan Zhaokun Di Zechao Wang Hongyu Tian Binghui Jia Zhiping | 2003 | Chemical Physics Letters2003，376，1： | 1 |
| 6 | Sedimentary record of polycyclic aromatic hydrocarbons in a reservoir in Northeast China显示文摘 | Lin Tian Qin Yanwen Zheng Binghui | 2012 | Environ- mental Pollution2012，163，： | 1 |
| 7 | Nitrate removal by microbial enhancement in a riparian wetland显示文摘 | Yuansheng Pei Zhifeng Yang Binghui Tian | 2010 | Bioresource Technology2010，，14： | 1 |
| 8 | Ultra-broadband,fast,and polarization-sensitive photoresponse of low-symmetry 2D NdSb_(2)显示文摘Broadband photodetectors with polarization-sensitive ability have received extraordinary attention for modern optoelectronic devices.Ideal photodetectors should possess high responsivity,fast response,and good stability,which are rare to meet at the same time in one low-symmetric two-dimentional(2D)material.In this work,neodymium diantimonides(RSb_(2)),a member of light rare-earth diantimonides RSb_(2)(R=La–Nd,Sm)with low-symmetry structure,is introduced as a fascinating highly anisotropic 2D material for broadband detection(532 nm to 4μm).The photodetector exhibits a responsivity of 0.49 mA·W^(−1)with 15μs response time at 532 nm and highly stable performance under ambient conditions over 8 months.Furthermore,we identify the polarization-sensitive photoresponse of the detector and demonstrate a high anisotropic factor~1.6.In addition,strong inplane anisotropy is revealed by anisotropic phonon response and the photodetection mechanism is investigated by scanning photocurrent microscopy measurements.This pioneer work on RSb_(2)paves the way for further exploration of 2D RSb_(2)for high performance polarized photodetectors with fast photothermoelectric response. | Gang Li Hanlin Zhang Yong Li Shiqi Yin Xucai Kan Wensen Wei Haifeng Du Binghui Ge Chao An Mingliang Tian Feng Yan Sanjun Yang Tianyou Zhai Liang Li | 2022 | Nano Research2022，15，6： | 1 |
| 9 | Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli显示文摘 | Guanjun Gao Bing Tian Lili Liu Duohong Sheng Binghui Shen Yuejin Hua | 2003 | DNA Repair2003，，12： | 1 |
| 10 | PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans显示文摘 | Yuejin Hua Issay Narumi Guanjun Gao Bing Tian Katsuya Satoh Shigeru Kitayama Binghui Shen | 2003 | Biochemical and Biophysical Research Communications2003，，2： | 1 |
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