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| 1 | Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study显示文摘AIM To identify a set of contributors, and weight and rank them on a pathophysiological basis.METHODS Patients who have undergone a lactulose or glucose hydrogen breath test to rule out small intestinal bacterial overgrowth(SIBO) for various clinical symptoms, including diarrhoea, weight loss, abdominal pain, cramping or bloating, were seen as eligible for inclusion in a retrospective single-centre study. Clinical data such as co-morbidities, medication, laboratory parameters and other possible risk factors have been identified from the electronic data system. Cases lacking or with substantially incomplete clinical data were excluded from the analysis. Suspected contributors were summarised under four different pathophysiological pathways(impaired gastric acid barrier, impaired intestinal clearance, immunosuppression and miscellaneous factors including thyroid gland variables) and investigated using the χ2 test, Student's t-test and logistic regression models.RESULTS A total of 1809 patients who had undergone hydrogen breath testing were analysed. Impairment of the gastric acid barrier(gastrectomy, odds ratio: OR = 3.5, PPI therapy OR = 1.4), impairment of intestinal clearance(any resecting gastric surgery OR = 2.6, any colonicresection OR = 1.9, stenosis OR = 3.4, gastroparesis OR = 3.4, neuropathy 2.2), immunological factors(any drug-induced immunosuppression OR = 1.8), altered thyroid gland metabolism(hypothyroidism OR = 2.6, levothyroxine therapy OR = 3.0) and diabetes mellitus(OR = 1.9) were associated significantly to SIBO. Any abdominal surgery, ileocecal resection, vagotomy or Ig A-deficiency did not have any influence, and a history of appendectomy decreased the risk of SIBO. Multivariate analysis revealed gastric surgery, stenoses, medical immunosuppression and levothyroxine to be the strongest predictors. Levothyroxine therapy was the strongest contributor in a simplified model(OR = 3.0).CONCLUSION The most important contributors for the development of SIBO in ascending order are immunosuppression, impairment of intestinal clearance and levothyroxine use, but they do not sufficiently explain its emergence. | Thorsten Brechmann Andre Sperlbaum Wolff Schmiegel | 2017 | World Journal of Gastroenterology2017，23，5： | 6 |
| 2 | Successful treatment of life-threatening bleeding from a duodenal posterior bulb peptic ulcer by an over-the-scope-clip显示文摘Bleeding of peptic ulcer at the posterior duodenal bulb still is a particular endoscopic challenge with increased risk of treatment failure and worse outcome.In this article,we report successful treatment of an actively bleeding peptic ulcer located at the posterior duodenal wall,using an over-the-scope-clip in the case of a 54-year-old male patient with hemorrhagic shock.Incident primary hemostasis was achieved and no adverse events occurred during a follow-up of 60 d. | Thorsten Brechmann Wolff Schmiegel | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 3 | Triggers of histologically suspected drug-induced colitis显示文摘BACKGROUND Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents.Although withdrawal of the causative agent would cure the disease knowledge is scarce and mostly derives from case reports and series.AIM To investigate potential triggers of drug-induced colitis(DiC).METHODS We conducted a retrospective,observational case control study.Patients were assigned to DiC or one of two age-and gender-matched control groups(noninflammatory controls and inflammatory colitis of another cause)based on histopathological findings.Histopathology was reassessed in a subset of patients(28 DiC with atherosclerosis,DiC without atherosclerosis and ischaemic colitis each)for validation purposes.Medical history was collected from the electronic database and patient records.Statistical analysis included chi-squared test,t-test,logistic and multivariate regression models.RESULTS Drug-induced colitis was detected in 211 endoscopically sampled biopsy specimens of the colon mucosa(7%of all screened colonoscopic biopsy samples);a total of 633 patients were included equally matched throughout the three groups(291 males,mean age:62.1±16.1 years).In the univariate analysis,DiC was associated with diuretics,dihydropyridines,glycosides,ASS,platelet aggregation inhibitors,nonsteroidal anti-inflammatory drugs(NSAIDs),statins and fibrates,and with atherosclerosis,particularly coronary heart disease,and hyperlipoproteinaemia.Echocardiographic parameters did not show substantial differences.In the multivariate analysis only fibrates[odds ratio(OR)=9.1],NSAIDs(OR=6.7)and atherosclerosis(OR=2.1)proved to be associated with DiC.Both DiC reassessment groups presented milder inflammation than ischaemic colitis.The DiC patients with atherosclerosis exhibited histological features from both DiC without atherosclerosis and ischaemic colitis.CONCLUSION Several drugs indicated for the treatment of cardiovascular and related diseases are associated with DiC.Atherosclerosis and microcirculatory disturbances seem to play an important pathogenetic role. | Thorsten Brechmann Katharina Günther Matthias Neid Wolff Schmiegel Andrea Tannapfel | 2019 | World Journal of Gastroenterology2019，25，8： | 3 |
| 4 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 5 | Development of CO2 Selective Poly(Ethylene Oxide)-Based Membranes: From Laboratory to Pilot Plant Scale显示文摘气体膜分离法是从气流中分离二氧化碳(CO_2)的最有前途的技术之一。例如,采用该技术对燃烧过程中的烟气进行处理,以达到CO_2捕集和封存的目的。聚环氧乙烷嵌段共聚物能够很好地应用于膜分离技术,如Pebax~?或Poly Active^(TM)。本文采用Poly Active^(TM)作为复合薄膜的选择层。在环境温度下,当CO_2/N_2选择性超过55时,这种薄膜的CO_2渗透率高达4 m^3(STP)·m^(–2)·h^(–1)·bar^(–1)(注:1 bar=105 Pa)。这种薄膜可以按照中试规模进行生产放大,而且可以设计成不同的平面膜组件。采用单一气体渗透数据作为唯一的实验输入而开发出的仿真工具可以准确预测这种膜组件的性能。在不同的中试研究中,我们利用烟气和沼气作为原料气流,反复检测这些膜和膜组件的性能。Poly Active^(TM)在检测中显示出了稳定的分离性能,表明Poly Active^(TM)非常适用于作为膜材料进行工业规模气体处理。 | Torsten Brinkmann Jelena Lilleparg Heiko Notzke Jan Pohlmann Sergey Shishatskiy Jan Wind Thorsten Wolff | 2017 | Engineering2017，3，4： | 3 |
| 6 | Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3显示文摘 | Christina Ehrhardt Christian Kardinal Walter J. Wurzer Thorsten Wolff Christoph von Eichel-Streiber Stephan Pleschka Oliver Planz Stephan Ludwig | 2004 | FEBS Letters2004，，： | 1 |
| 7 | Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury显示文摘 | Susanne Herold Stephan Ludwig Stephan Pleschka Thorsten Wolff | 2012 | Journal of Leukocyte Biology2012，，： | 1 |
| 8 | Double--Strand- ed binding of influenza B Vuirus Nonstructural NSI protein inhibits protein kinase R but is essential to antagonize production of alpha/ beta interferon显示文摘 | Bianca Dauber Jana Schneider Thorsten Wolff | 2006 | Journal of Virology2006，12，11： | 1 |
| 9 | Gastrointestinal bleeding 30 years after a complicated cholecystectomy显示文摘Gastrointestinal bleeding from small-bowel varices is a rare and difficult to treat complication of portal hypertension. We describe the case of a 79-year-old female patient with recurrent severe hemorrhage from smallbowel varices 30 years after a complicated cholecystectomy. When double balloon enteroscopy was unsuccessful to reach the site of bleeding, a rendezvous approach was favored with intraoperative endoscopy. Active bleeding from varices within a biliodigestive anastomosis was found and controlled by endoscopic injection of cyanoacrylate. Intraoperative endoscopy should be considered in the case of life-threatening gastrointestinal hemorrhage that is not accessible by conventional endoscopy. | Thorsten Brechmann Wolff Schmiegel Volkmar Nicolas Markus Reiser | 2010 | World Journal of Gastroenterology2010，16，37： | 0 |
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