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2篇 您的检索式：作者名="Thorsten Bergmann"

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		题名	作者	年代	出处	被引量
	1	Gene therapeutic approaches to inhibit hepatitis B virus replication显示文摘Acute and chronic hepatitis B virus(HBV) infections remain to present a major global health problem. The infection can be associated with acute symptomatic or asymptomatic hepatitis which can cause chronic inflammation of the liver and over years this can lead to cirrhosis and the development of hepatocellularcarcinomas. Currently available therapeutics for chronically infected individuals aim at reducing viral replication and to slow down or stop the progression of the disease. Therefore, novel treatment options are needed to efficiently combat and eradicate this disease. Here we provide a state of the art overview of gene therapeutic approaches to inhibit HBV replication. We discuss non-viral and viral approaches which were explored to deliver therapeutic nucleic acids aiming at reducing HBV replication. Types of delivered therapeutic nucleic acids which were studied since many years include antisense oligodeoxynucleotides and antisense RNA, ribozymes and DNAzymes, RNA interference, and external guide sequences. More recently designer nucleases gained increased attention and were exploited to destroy the HBV genome. In addition we mention other strategies to reduce HBV replication based on delivery of DNA encoding dominant negative mutants and DNA vaccination. In combination with available cell culture and animal models for HBV infection, in vitro and in vivo studies can be performed to test efficacy of gene therapeutic approaches. Recent progress but also challenges will be specified and future perspectives will be discussed. This is an exciting time to explore such approaches because recent successes of gene therapeutic strategies in the clinic to treat genetic diseases raise hope to find alternative treatment options for patients chronically infected with HBV.	Maren Gebbing Thorsten Bergmann Eric Schulz Anja Ehrhardt	2015	World Journal of Hepatology2015，7，2：	2
	2	On-road and laboratory investigation of low-level PM emissions of a modern diesel particulate filter equipped diesel passenger car显示文摘	Maik Bergmann Ulf Kirchner Rainer Vogt Thorsten Benter	2009	Atmospheric Environment2009，，11：	1

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