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| 1 | RhoA/Rho激酶在大鼠阴茎勃起机制中的调节作用显示文摘 一般认为一氧化氮(nitricoxide,NO)释放增加促进小动脉和海绵体平滑肌舒张是导致男性阴茎勃起的主要机制.研究发现内源性血管收缩因子对维持阴茎萎软状态有重要作用.应用大鼠模型活体检测使用Y 27632拮抗Rho 激酶活性后对阴茎勃起生理机制的影响;应用免疫转印技术检测阴茎海绵体内RhoA和Rho激酶蛋白的表达.结果显示在大鼠海绵体组织内有内源性RhoA和Rho激酶蛋白的表达和存在;Y 27632海绵体内注射阻滞RhoA/Rho激酶活性使ICP和CCP/MAP比值明显升高;局部小剂量应用Y 27632对MAP没有明显影响;Y 27632可增强系列电刺激引起的由NO介导的CCP/MAP比值的增加;NO合成酶和鸟苷酸环化酶抑制剂的作用不能阻滞RhoA/Rho激酶抑制剂对大鼠阴茎海绵体平滑肌的松弛作用和CCP/MAP的增加.说明RhoA/Rho激酶信号系统发挥了维持海绵体萎软状态重要作用,这是与NO介导途径不同的阴茎勃起生理调节机制.RhoA/Rho激酶抑制剂可能是ED治疗的新领域新方法. | 戴玉田 孙则禹 Thomas M.Mills Kanchan Chitaley Webb R.Clinton Ronald W.Lewis | 2002 | 南京大学学报(自然科学版)2002，38，5： | 11 |
| 2 | 抑制平滑肌的张力收缩:一种治疗勃起功能障碍的新途径显示文摘阴茎海绵体血管的收缩及张力的维持是由钙敏感的RhoA/Rho激酶信号传导途径介导的。以Y 2 76 32抑制海绵体平滑肌细胞的Rho激酶信号系统可促进阴茎勃起 ,表现为海绵体内压 (ICP)明显升高 ,而平均动脉压 (MAP)变化不显著。为什么在血管收缩信号很强的情况下性刺激仍能引发阴茎勃起反应 ?我们设想体内一氧化氮 (NO)能直接抑制RhoA/Rho激酶途径的活性 ,减少血管张力 ,促使血管舒张 ,勃起发生 ,使用Y 2 76 32可以恢复性腺功能低下和高血压病动物ED模型的阴茎勃起功能 ,这表明抑制Rho激酶活性药物具有临床应用的前景。此外 ,我们的结果显示阴茎表面使用Rho激酶抑制剂可能为ED治疗的有效方法之一。 | 戴玉田 Thomas M MILLS Ronald W LEWIS RClinton WEBB | 2002 | 中华男科学杂志2002，8，6： | 8 |
| 3 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 4 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 5 | Predictors of Comprehension during Surgical Informed Consent显示文摘 | Aaron S. Fink Allan V. Prochazka William G. Henderson Debra Bartenfeld Carsie Nyirenda Alexandra Webb David H. Berger Kamal Itani Thomas Whitehill James Edwards Mark Wilson Cynthia Karsonovich Patricia Parmelee | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 6 | Candidatus “Scalindua brodae”, sp. nov., Candidatus “Scalindua wagneri”, sp. nov., Two New Species of Anaerobic Ammonium Oxidizing Bacteria显示文摘 | Markus Schmid Kerry Walsh Rick Webb W. Irene Rijpstra Katinka van de Pas-Schoonen Mark Jan Verbruggen Thomas Hill Bruce Moffett John Fuerst Stefan Schouten Jaap S. Sinninghe Damsté James Harris Phil Shaw Mike Jetten Marc Strous | 2003 | Systematic and Applied Microbiology2003，，4： | 1 |
| 7 | A 2-year study of Candida asso-ciated denture stomatitics treatment in aged care subjects显示文摘 | Webb BC Thomas CJ Whittle T | 2005 | Gerodontology2005，22，3： | 1 |
| 8 | Pediatric ECMO for severe quinidine cardiotoxicity 显示文摘 | Tecklenburg FW Thomas N J Webb SA | 1997 | Pediatr Emerg Care1997，13，2： | 1 |
| 9 | δ13C values of soil organic matter in semiarid grassland with mesquite (Prosopis)encroachment in southeastern Arizona显示文摘 | Thomas H Biggs Jay Quade Robert H Webb | 2002 | Geoderma2002，110，12： | 1 |
| 10 | Using statistics and mathematical modelling to understand infectious disease outbreaks:COVID-19 as an example显示文摘During an infectious disease outbreak,biases in the data and complexities of the underlying dynamics pose significant challenges in mathematically modelling the outbreak and designing policy.Motivated by the ongoing response to COVID-19,we provide a toolkit of statistical and mathematical models beyond the simple SIR-type differential equation models for analysing the early stages of an outbreak and assessing interventions.In particular,we focus on parameter estimation in the presence of known biases in the data,and the effect of non-pharmaceutical interventions in enclosed subpopulations,such as households and care homes.We illustrate these methods by applying them to the COVID-19 pandemic. | Christopher E.Overton Helena B.Stage Shazaad Ahmad Jacob Curran-Sebastian Paul Dark Rajenki Das Elizabeth Fearon Timothy Felton Martyn Fyles Nick Gent Ian Hall Thomas House Hugo Lewkowicz Xiaoxi Pang Lorenzo Pellis Robert Sawko Andrew Ustianowski Bindu Vekaria Luke Webb | 2020 | Infectious Disease Modelling2020，5，1： | 1 |
| 11 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs 显示文摘 | Stephen F Thomas L M Alejandro A S Jinghui Zhang Zheng Zhang Webb M David J L | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 12 | Effetiveness of two methods of denture sterilization显示文摘 | Thomas CJ Harty DW | 1998 | J Oral Rehabil1998，25，6： | 1 |
| 13 | Inhibition of inducible nitric oxide synthase results in reductions in wound vascular endothelial growth factor expression, granulation tissue formation, and local perfusion显示文摘 | Thomas R. Howdieshell Whitney L. Webb Paul L. McNeil | 2003 | Surgery2003，，5： | 1 |
| 14 | Identification & characterisation of the two nover streptococcal pyrogenic exotoxins SPE-L & SPE-M 显示文摘 | Thomas P Webb PD Handley V | 2004 | Indian J Med Res2004，，： | 1 |
| 15 | Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth显示文摘 | Webb DJ Thomas KS Gonias SL | 2001 | The Journal of Cell Biology2001，152，： | 1 |
| 16 | Structure-specific binding of the two tan- dem hmg boxes of hmgl to four-way junction DNA is mediat- ed by the a domain显示文摘 | Webb M Thomas JO | 1999 | Journal of molecular biology1999，294，2： | 1 |
| 17 | Adhesion assembly,disassembly and turnover in migrating cells-over and over and over again显示文摘 | Donna J Webb J Thomas P | | 0，，： | 1 |
| 18 | Assessing the role of contact tracing in a suspected H7N2 influenza A outbreak in humans in Wales显示文摘 | Eames K T Webb C Thomas K Smith J Salmon R Temple J M | 2010 | BMC Infect Dis2010，10，： | 1 |
| 19 | The use of the Taguchi design of experiment method in optimizing splicing conditions for a Nylon 66 yarn显示文摘 | Webb C J Waters GT Thomas A J | 2007 | Journal of the Textile Institute2007，98，4： | 1 |
| 20 | Candidatus “Scalindua brodae”, sp. nov., Candidatus “Scalindua wagneri”, sp. nov., Two New Species of Anaerobic Ammonium Oxidizing Bacteria显示文摘 | Markus Schmid Kerry Walsh Rick Webb W. Irene Rijpstra Katinka van de Pas-Schoonen Mark Jan Verbruggen Thomas Hill Bruce Moffett John Fuerst Stefan Schouten Jaap S. Sinninghe Damsté James Harris Phil Shaw Mike Jetten Marc Strous | 2003 | Systematic and Applied Microbiology2003，，4： | 1 |
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