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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | An ecosystem approach for determining environmental water allocations in Australian dryland river systems: the role of geomorphology显示文摘 | Thoms M C Sheldon F | 2002 | Geomorphology2002，47，： | 1 |
| 3 | Reclamation Experience with Overtopping Protection 显示文摘 | William F Petter G Thoms H | 1995 | International Water Resources Engineering Con{erence Proceedings1995，，8： | 1 |
| 4 | Granular cell change in astrocytic tumors显示文摘 | Geddes J F Thom M Robinson S | 1996 | Am J Surg Pathol1996，20，： | 1 |
| 5 | Chronic renal disease, inflammation and atherosclerosis: new concepts about an old problem 显示文摘 | Dummer C D Thomé F S Veronese F V | 2007 | Rev Assoc Med Bras2007，53，5： | 1 |
| 6 | Accommodation,accommodative convergence,and response AC/A ratios before and at the onset of myopia in children显示文摘 | Gwiazda J Thom F Held R | 2005 | Optom Vis Sci2005，82，4： | 1 |
| 7 | Identifying the key Parameters that Influence Geogrid Reinforcement of Railway Ballast 显示文摘 | Brown S F Kwan J Thom N H | 2007 | Geotextiles and Geomembranes2007，，6： | 1 |
| 8 | Prevalence of perceived stress,symptoms of depression and sleep disturbances in relation to information and communication technology (ICT) use among young adults-an explorative prospective study显示文摘 | Thomée S Ekl(o)f M Gustafsson E | 2007 | Comput Human Behav2007，23，3： | 1 |
| 9 | Scatterblogs2: real-timemonitoring of microblog messages through user-guided filtering显示文摘 | Bosch H Thom D Heimerl F | 2013 | IEEE Transactions on Visualization and Computer Graphics2013，19，12： | 1 |
| 10 | Identifying the Key Parameters That Influence Geogrid Reinforcement of Railway Ballast显示文摘 | BROWN S F KWAN J THOM N H | 2007 | Geotextiles and Geomembranes2007，25，6： | 1 |
| 11 | An ecosystem approach for detrmining environmental water allocations in Australian dryland river systems:the role of geomorphology显示文摘 | Thoms M C Sheld F | | 0，，47： | 1 |
| 12 | 2H NMR and 13CIRMSanalyses of acetic acid from vinegar, 180-IRMS analysis of water in vinegar: Internationalcollaborative study report显示文摘 | THOM AS F JAMIN E | 2009 | Analytica ChimicaActa2009，649，1： | 1 |
| 13 | Change in corneal shape and corneal wave-front aberrations with accommodation显示文摘 | He JC Gwiazda J Thom F | 2003 | J Vis2003，3，： | 1 |
| 14 | An ecosystem approach for determining environmental water allocations in Australian dryland river systems:The role of geomorphology显示文摘 | Thoms M C Sheldon F | 2002 | Geomorphology2002，，47： | 1 |
| 15 | Modelling of gas transport phenomena in SOFC Anodes显示文摘 | Lehnert W Meusinger J Thom F | 2000 | Power Sources2000，87，： | 1 |
| 16 | A Study of Grid Reinforced Asphalt to Combat Reflection Cracking 显示文摘 | Brown S F Thom N H Sanders P J | 2000 | Journal of the Association of Asphalt Paving Technolo- gists2000，70，： | 1 |
| 17 | Three dimensional CFD mod-el of a planar solid oxide electrolysis cell for Co-electrolysis of steam and carbon dioxide显示文摘 | Lehnert W Meusinger J Thom F | | 0，，： | 1 |
| 18 | Dose refractive error change twice as fast as corneal power in orthokeratology?显示文摘 | Erickson P Thom F | 1977 | Am J Optom Physiol Opt1977，54，9： | 1 |
| 19 | Sampling errors in the estimation of empirical or thogonal functions显示文摘 | North G R Thom as L B Caha lan R F | | 0，，： | 1 |
| 20 | Accommodation, Accommodative Con-vergence,and Response AC/A Rations Before and the onset ofmyopia in children显示文摘 | Gwiazda J Thom F Held R | 2005 | Optom Vis Sci2005，82，4： | 1 |
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