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| 1 | Colorectal cancer: From prevention to personalized medicine显示文摘Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the transformation of normal colonic mucosa into invasive cancer.CRC is one of the most prevalent and incident cancers worldwide,as well as one of the most deadly.Approximately 1235108 people are diagnosed annually with CRC,and 609051 die from CRC annually.The World Health Organization estimates an increase of77%in the number of newly diagnosed cases of CRCand an increase of 80%in deaths from CRC by 2030.The incidence of CRC can benefit from different strategies depending on its stage:health promotion through health education campaigns(when the disease is not yet present),the implementation of screening programs(for detection of the disease in its early stages),and the development of nearly personalized treatments according to both patient characteristics(age,sex)and the cancer itself(gene expression).Although there are different strategies for screening and although the number of such strategies is increasing due to the potential of emerging technologies in molecular marker application,not all strategies meet the criteria required for screening tests in population programs;the three most accepted tests are the fecal occult blood test(FOBT),colonoscopy and sigmoidoscopy.FOBT is the most used method for CRC screening worldwide and is also the primary choice in most population-based screening programs in Europe.Due to its non-invasive nature and low cost,it is one of the most accepted techniques by population.CRC is a very heterogeneous disease,and with a few exceptions(APC,p53,KRAS),most of the genes involved in CRC are observed in a small percentage of cases.The design of genetic and epigenetic marker panels that are able to provide maximum coverage in the diagnosis of colorectal neoplasia seems a reasonable strategy.In recent years,the use of DNA,RNA and protein markers in different biological samples has been explored as strategies for CRC diagnosis.Although there is not yet sufficient evidence to recommend the analysis of biomarkers such as DNA,RNA or proteins in the blood or stool,it is likely that given the quick progression of technology tools in molecular biology,increasingly sensitive and less expensive,these tools will gradually be employed in clinical practice and will likely be developed in mass. | Gemma Binefa Francisco Rodríguez-Moranta àlex Teule Manuel Medina-Hayas | 2014 | World Journal of Gastroenterology2014，20，22： | 67 |
| 2 | Investigating soil moisture–climate interactions in a changing climate: A review显示文摘 | Sonia I. Seneviratne Thierry Corti Edouard L. Davin Martin Hirschi Eric B. Jaeger Irene Lehner Boris Orlowsky Adriaan J. Teuling | 2010 | Earth Science Reviews2010，，3： | 3 |
| 3 | Handwriting movement an- aJyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone 显示文摘 | Caligiuri MP Teulings HL Dean CE | 2010 | Psychiatry Res2010，177，12： | 1 |
| 4 | Handwriting movement an- alyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone 显示文摘 | Caligiuri MP Teulings HL Dean CE | 2009 | Hum Mov Sei2009，28，5： | 1 |
| 5 | SK2 channel expression and function in cerebellar Purkinje cells显示文摘 | Hosy E Piochon C Teuling E Rinaldo L Hansel C | 2011 | J Physiol2011，589，14： | 1 |
| 6 | Enhanced procedur- al learning following beta - amyloid protein ( 1 -42 ) infusion in the rat 显示文摘 | Ammassari - Teule M Middei S Passino E | 2002 | Neuroreport2002，13，13： | 1 |
| 7 | Long-term prognosis of patients with cardiac syndrome X :a review显示文摘 | Vermelffoort IA Teule GJ van Dijk AB | 2012 | Neth Heart J2012，20，9： | 1 |
| 8 | Silkworms transformedwith chimeric silkworm/spider silk genes spin composite silkfibers with improved mechanical properties显示文摘 | Teul é F Miao Y G Sohn B H | 2012 | Proceedings ofthe National Academy of Sciences2012，109，3： | 1 |
| 9 | Time- and dosedependent effects of cureumin on gene expression in human colon cancer cells 显示文摘 | van Erk MJ Teuling E Staal YC | 2004 | J Carcinog2004，3，1： | 1 |
| 10 | Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties 显示文摘 | TEULE F MIAO Yungen SOHN B H | 2012 | Proc NatlAcadSci USA2012，109，3： | 1 |
| 11 | Vital dye and radio- labelled colloids - complement or alternative? 显示文摘 | Pijpers R Borgstein P J Teule GJ | 2000 | Recent Results Cancer Res2000，157，： | 1 |
| 12 | Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties显示文摘 | Teuléa F Miaob Y G Sohnc B H | 2012 | PNAS2012，109，3： | 1 |
| 13 | Neuron specific expression of mutant SOD1 protein is sufficient to cause motor neuron disease in mice显示文摘 | Jaarsma D Teuling E Haasdijk E D De Zeeuw C l Hoogenraad C C | 2008 | J Neurosci2008，28，： | 1 |
| 14 | Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints 显示文摘 | Teul J Ruperez F J Garcia A | 2009 | J Proteome Res2009，8，12： | 1 |
| 15 | Silkworms trans- formed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties 显示文摘 | Teule F Miao Y G Sohn B H | 2012 | Proceedings of the National Academy of Sciences of the United States of America2012，109，3： | 1 |
| 16 | Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties显示文摘 | TeuléF Miao Y G Sohn B H | 2012 | Proc Natl Acad Sci USA2012，109，3： | 1 |
| 17 | Rhinitis as a cause of respiratory disorders during pregnancy显示文摘 | Dzieciolowska - Baran E Teul - Swiniarska I Gawlikowska - Sroka A | 2013 | Adv Exp Med Biol2013，755，： | 1 |
| 18 | Nasal septum morphology in human fetuses in computed tomography images显示文摘 | TEUL I SLAWINSKI G LEWANDOWSKI J | 2010 | Eur J Med Res2010，152，： | 1 |
| 19 | Modifications of spider silk sequences in an attempt to control the mechanical properties of the synthetic fibers显示文摘 | Teule F Furin W A Cooper A R | 2007 | J Mater Sci2007，42，21： | 1 |
| 20 | Nephila clavipes Flagelliform silk-like GGX motifs contribute to extensibility and spacer motifs contribute to strength in syntbetic spider silk fibers显示文摘 | Adrianos S L Teule F Hinman M B | 2013 | Biomacromolecules2013，14，6： | 1 |
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