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| 1 | Alcohol and hepatocellular carcinoma:A review and a point of view显示文摘It is well recognized that one cause of chronic liver disease and hepatocellular carcinoma(HCC)is alcohol consumption.Research in Italy and the United States concludes that the most common cause of HCC(responsible for 32%to 45%of HCC)is alcohol.It has recently been shown that a significant relationship between alcohol intake,metabolic changes,and hepatitis virus infection does exist.Alcohol may be a factor in the development of HCC via direct(genotoxic)and indirect mechanisms(cirrhosis).There is only one way of diagnosing HCC,which is early identification through surveillance,when curative treatments become possible.After stopping alcohol intake the risk of liver cancer decreases by 6%to 7%a year,and an estimated time period of 23 years is also needed.Therefore,surveillance is also important in former drinkers and,in our opinion,independently from the presence of compensated cirrhosis.In cases of very early stage(VES)and early stage with portal hypertension,liver transplantation is the optimal option;and in cases of associated disease,percutaneous ethanol injections,radiofrequency and microwave ablation are the ideal treatments.Despite the possibility of detecting microvascular invasion with HR,several studies and some randomized controlled trials revealed that overall survival and DSF rates in patients with VES HCC are much the same after ablation and HR.Therefore,ablation can be regarded as a firstline choice for patients with VES HCC.It is important to emphasize that the choice of treatment should be weighed carefully in the context of a multidisciplinary cancer team. | Gianni Testino Silvia Leone Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，43： | 21 |
| 2 | Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement显示文摘Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis,fibrosis,and cirrhosis to hepatocellular carcinoma.Forty-four per cent of all deaths from cirrhosis are attributed to alcohol.Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation(LT).The vast majority of transplant programmes(85%)require 6 mo of abstinence prior to transplantation;commonly referred to as the'6-mo rule'.Both in the case of progressive end-stage liver disease(ESLD)and in the case of severe acute alcoholic hepatitis(AAH),not responding to medical therapy,there is a lack of evidence to support a 6-mo sobriety period.It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking.The'Group of Italian Regions'suggests that:in a case of ESLD with model for end-stage liver disease<19 a 6-mo abstinence period is required;in a case of ESLD,a 3-mo sober period before LT may be more ideal than a 6-mo period,in selected patients;and in a case of severe AAH,not respond-ing to medical therapies(up to 70%of patients die within 6 mo),LT is mandatory,even without achieving abstinence.The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist.Patients have to participate in self-help groups. | Gianni Testino Patrizia Burra Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 3 | Chemoprevention of hepatocellular carcinoma in patients with hepatitis C virus related cirrhosis显示文摘Interferon(IFN) therapy has been reported to decrease the risk of hepatocellular carcinoma(HCC) and improve survival by preventing liver-related deaths in patients with chronic hepatitis C virus(HCV) infection, while the role of IFN therapy on the natural history of hepatitis C related cirrhosis is still under debate. The ideal goal of therapy is to prevent the progression into end-stage disease. The use of IFN in patients with HCV compensated cirrhosis reduces the negative clinical evolution independently of the type of laboratoristic and virological response. In our experience, IFN therapy in HCV compensated cirrhosis is barely useful in prevention of HCC, as cirrhosis itself represents a risk of cancer.Some authors noted that IFN treatment reduces the risk of HCC independently of the virological response. It would probably be interesting to evaluate the efficacy of weekly low-dose pegylated(PEG)-IFN therapy in patients with HCV cirrhosis and to assess potential benefits of long-term PEG-IFN plus Ribavirin treatment. | Gianni Testino Paolo Borro | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 4 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 5 | Intestinal metaplasia, high-grade epithelial dysplasia and gastric cancer 显示文摘 | TESTINO G CONRAGGIA M DE LACO F | 2002 | Scand J Gastroenterol2002，37，12： | 1 |
| 6 | Combination hepatitis C virus antigen and antibody immunoassay as a new tool for early diagnosis of infection显示文摘 | Ansaldi F Bruzzone B Testino G | 2006 | J Viral Hepat2006，13，1： | 1 |
| 7 | Size and shape control of SrTiO3 particles grown by epitaxial self-assembly显示文摘 | CALDERONE V R TESTINO A BUSCAGLIA M T | 2006 | Chem Mater2006，18，6： | 1 |
| 8 | Helicobacter pylori influence on gastric acid secretion in duodenal ulcer patients diagnosed for the first time 显示文摘 | Testino G cornaggia M DeIaco F | 2002 | Panminerva Med2002，44，： | 1 |
| 9 | Acrylamide effects on kinesin-related proteins of the mitotic/meiotic spindle 显示文摘 | Sickles DW Sperry AO Testino A | 2007 | Toxicol Appl Pharmacol2007，222，： | 1 |
| 10 | Type-2 hepatorenalsyndrome and refractory ascites:role of transjugularintrahepatic portosystemic stent-shunt in eighteen patientswith advanced cirrhosis awaiting orthotopic livertransplantation显示文摘 | Testino G Ferro C Sumberaz A | 2003 | Hepatogastroenterology2003，50，54： | 1 |
| 11 | High-throughput inhibition screening of major human eytochrome P450 enzymes using an in vitro cock- tail and liquid chromatography-tandem mass spectrometry 显示文摘 | TESTINO SA JR PATONAY G | 2003 | J Pharm Biomed Anal2003，30，5： | 1 |
| 12 | Treatment of alcohol dependence: recent progress and reduction of consumption 显示文摘 | Testino G Leone S Borro P | 2014 | Minerva Med2014，105，6： | 1 |
| 13 | The influence of concentration on the formation of Ba- TiO3 by direct reaction of TiCL with Ba(OH)2 in aque- ous solution显示文摘 | VIVIANI M BUSCAGLIA M T TESTINO A | 2003 | Journal of the European Ceramic So- ciety2003，，23： | 1 |
| 14 | Helicobacter pylori influence on gastric acid secretion in duodenal ulcer patients diagnosed for the first time 显示文摘 | Cornaggia M De Iaco F | 2002 | Panminerva Med2002，44，1： | 1 |
| 15 | Gastric precancerous changes: carcinogenesis, clinical behaviour immunophenotype study and surveillance 显示文摘 | Testino G | 2006 | Panmin- ervaMed2006，48，2： | 1 |
| 16 | Liver Transplantation in Alcoholic Patients显示文摘 | Gianni Testino Silvia Leone Alessandro Sumberaz Paolo Borro | 2014 | Alcohol Clin Exp Res2014，，6： | 1 |
| 17 | Synthesis of BaTiO3 particles with tailored size by precipitation from aqueous solutions 显示文摘 | TESTINO A BUSCAGLIA M T VIVIANI M | 2004 | J Am Ceram Soc2004，87，1： | 1 |
| 18 | Kinetic modcling of aqueous and hydrothermal synthesis of barium titanate (Ba-TiO3) 显示文摘 | TESTINO A BUSCAGLIA V BUSCAGLIA M T | 2005 | Chem Mater2005，17，21： | 1 |
| 19 | Simple and Template-free Method for Preparation of (Zn显示文摘 | TESTINO A BELLOBONO I R BUSCAGLIA V | | 0，，： | 1 |
| 20 | Gastric preneoplastic changes显示文摘 | Testino G | 2004 | Hecemti Prog Med2004，95，5： | 1 |
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