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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study显示文摘 | Hermans G Agten A Testelmans D | 2010 | Crit Care2010，14，4： | 1 |
| 3 | Intermittent spontaneous breathing protects the rat diaphragm from mechanical ventilation effects 显示文摘 | Gayan-Ramirez G Testelmans D Maes K | 2005 | Crit Care Med2005，33，12： | 1 |
| 4 | Atrophy and hypertrophy signalling in the diaphragm of patients with COPD显示文摘 | Testelmans D Crul T Maes K | | 0，，： | 1 |
| 5 | Pro- file of circulating cytokines : impact of OSA, obesity and a- cute cardiovascular events 显示文摘 | Testelmans D Tamisier R Barone-Rochette G | 2013 | Cytokine2013，62，2： | 1 |
| 6 | Profile of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events显示文摘 | Dries Testelmans Renaud Tamisier Gilles Barone-rochette Jean-Philippe Baguet Pascale Roux-Lombard Jean-Louis Pépin Patrick Lévy | 2013 | Cytokine2013，，： | 1 |
| 7 | Atrophy and hypertro?phy signalling in the diaphragm of patients with COPD显示文摘 | Testelmans D Crul T Maes K et a1 | 2010 | Eur RespirJ2010，35，3： | 1 |
| 8 | Leupeptin inhibits ventilator - induced diaphragm dysfunction in rats 显示文摘 | Maes K Testelmans D Powers S | 2007 | Am J Respir Crit Care Med2007，175，11： | 1 |
| 9 | Non-invasive ventilation in amyotrophic lateral sclerosis显示文摘 | Vrijsen B Testelmans D Belge C | 2013 | Amyotroph Lateral Scler Frontotemporal Degener2013，14，2： | 1 |
| 10 | Gene expression pro?filing in vastus lateralis muscle during an acute exacerbation of COPD显示文摘 | Crul T Testelmans D Spruit MA et a1 | 2010 | Cell Physiol Biochem2010，25，45： | 1 |
| 11 | Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study 显示文摘 | Hermans G Agten A Testelmans D | 2010 | C rit Care2010，14，4： | 1 |
| 12 | Pro file of circulating cytokines: Impact of OSA, obesity and acute cardiovascular events 显示文摘 | Testelmans D Tamisier R Barone rochette G | 2013 | Cytokine2013，62，2： | 1 |
| 13 | Atrophy and hypertrophy sig-nalling in the diaphragm of patients with COPD显示文摘 | Testelmans D Crul T Maes K | 2010 | Eur Respir J2010，35，3： | 1 |
| 14 | Leupeptin inhibits ventilator-in- duced diaphragm dysfunction in rats显示文摘 | Maes K Testelmans D Powers S | 2007 | Am J Respir Crit Care Med2007，175，11： | 1 |
| 15 | Atrophy and hypertrophy signalling in the diaphragm of patients with COPD显示文摘 | Testelmans D Crul T Maes K | 2010 | Eur Respir J2010，35，： | 1 |
| 16 | Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease显示文摘 | Demedts I K Bracke K R van Pottelberge G Testelmans D Verleden G M Vermassen F E | 2007 | Am J Respir Crit Care Med2007，175，： | 1 |
| 17 | Rocuronium exaeerbates mechanical ventilation-induced diaphragm dysfunction in rats 显示文摘 | Testelmans D Maes K Wouters P | 2006 | Crit Care Med2006，34，12： | 1 |
| 18 | Infusions of rocuronium and eisatracurium exert different effects on rat diaphragm function 显示文摘 | Testelmans D Maes K Wouters P | 2007 | Intensive Care Med2007，33，5： | 1 |
| 19 | High dose methylprednisolone counteracts the negative effects ofrocuroniumon diaphragm function 显示文摘 | Maes K Testelmans D Thomas D | 2011 | Intensive Care Med2011，37，11： | 1 |
| 20 | Atrophy and hypertrophy signalling in the diaphragm of patients with COPD 显示文摘 | Testelmans D Crul T Maes K | 2010 | Eur Respir J2010，35，3： | 1 |
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