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| 1 | Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events显示文摘AIM: To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS: Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS: Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have signifi cantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer.CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. | Jennifer Y Wang Jonathan P Terdiman Eric Vittinghoff Tracy Minichiello Madhulika G Varma | 2009 | World Journal of Gastroenterology2009，15，8： | 8 |
| 2 | Controversies in the treatment of Crohn’s disease: The case for an accelerated step-up treatment approach显示文摘The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biological agents in the former versus initial treatment with steroids in the latter, with escalation to immunomodulators or biological drugs in patients proven to be steroid refractory or steroid dependent. Top-down therapy has been associated with higher rates of mucosal healing. If mucosal healing proves to be associated with better long-term outcomes, such as a decreased need for hospitalization and surgery, top-down therapy may be the better approach for many patients. The main concern with the top-down approach is the toxicity of the immunomodulators and biological agents, which have been linked with infectious complications as well as an increased risk of lymphoma. It is unlikely that one strategy will be best for all patients given the underlying heterogeneity of CD presentation and severity. Ultimately, we must weigh the safety and efficacy of the therapies with the risks of the disease itself. Unfortunately our ability to risk stratify patients at diagnosis remains rudimentary. The purpose of this paper is to review the data that supports or refutes the differing treatment paradigms in CD, and to provide a rationale for an approach, termed the 'accelerated step-up' approach, which attempts to balance the risks and benefits of our currently available therapies with the risk of disease related complications as we understand them in 2008. | Amandeep K Shergill Jonathan P Terdiman | 2008 | World Journal of Gastroenterology2008，14，17： | 4 |
| 3 | Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing显示文摘 | Terdiman JP Gum JR Conrad PG | 2001 | Gastroenterology2001，120，1： | 1 |
| 4 | Colorectal cancer screening: scientific review显示文摘 | WALSH JM TERDIMAN JP | 2003 | JAMA2003，289，10： | 1 |
| 5 | Evidence-based analysis: postoperative gastric bleeding: etiology and prevention显示文摘 | Jade S. Hiramoto Jonathan P. Terdiman Jeffrey A. Norton | 2003 | Surgical Oncology2003，，1： | 1 |
| 6 | The importance of accurate diagnosis and vigorous care ofthe patient with liver disease and gastrointestinal hemorrhage 显示文摘 | Terdiman JP | 1997 | Se-min Gastrointest Dis1997，8，4： | 1 |
| 7 | Disparities in outpatient and home health service utilization following stroke: Results of a 9 - year cohort study in Nor,hem California显示文摘 | Chan L Wang H Terdiman J | 2009 | PMR2009，1，： | 1 |
| 8 | Altered distribution of beta-catenin and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers显示文摘 | Aust DE Terdiman JP Willenbucher RF | 2001 | Mod Pathol2001，14，： | 1 |
| 9 | Gender as a Risk Factor for Advanced Neoplasia and Colorectal Cancer: A Systematic Review and Meta-analysis显示文摘 | Stephen P. Nguyen Stephen Bent Yea-Hung Chen Jonathan P. Terdiman | 2009 | Clinical Gastroenterology and Hepatology2009，，6： | 1 |
| 10 | Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability 显示文摘 | Umar A Boland CR Terdiman JP | 2004 | J Natl Cancer Inst2004，96，4： | 1 |
| 11 | Revised bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability显示文摘 | Umar Ar Boland CR Terdiman JP | 2004 | JNCI2004，96，4： | 1 |
| 12 | Comparison of selection strategies for genetic tesing of patients with hereditary nonpolyp- osis coloreetal carcinoma:effectiveness and cost-effectiveness显示文摘 | Reyes CM Allen BA Terdiman JP | 2002 | Cancer2002，95，9： | 1 |
| 13 | Incidence and significance of the low-voltage electrocardiogram in acute myocardial infarction显示文摘 | Rotmensch HH Meytes I Terdiman R | 1977 | Chest1977，71，6： | 1 |
| 14 | Surveillance guidelines should be updated to recognize the importance of serrated polyps显示文摘 | TERDIMAN J P MCQUAID K R | 2010 | Gastroenterology2010，139，5： | 1 |
| 15 | HNPCC:an uncommon but important diagnosis显示文摘 | Terdiman JP | 2001 | Gastroenterology2001，121，4： | 1 |
| 16 | Gastrointestinal bleeding in the hospitalized patient: a case-control study to assess risk factors, causes, and outcome显示文摘 | Terdiman JP Ostroff JW | 1998 | Am J Med1998，104，4： | 1 |
| 17 | Colorectal cancer screening: scientific review 显示文摘 | Walsh JM Terdiman JP | 2003 | JAMA2003，289，10： | 1 |
| 18 | Surveillance Guidelines Should Be Updated to Recognize the Importance of Serrated Polyps显示文摘 | Terdiman JP Mcquaid KR | 2010 | Gastroenterology2010，139，5： | 1 |
| 19 | American Gastroenterological Association Institute Guideline on the Use of Thiopurines, Methotrexate, and Anti–TNF-α Biologic Drugs for the Induction and Maintenance of Remission in Inflammatory Crohn’s Disease显示文摘 | Jonathan P. Terdiman Claudia B. Gruss Joel J. Heidelbaugh Shahnaz Sultan Yngve T. Falck–Ytter | 2013 | Gastroenterology2013，，6： | 1 |
| 20 | Disparities in outpatient and home health service utilization following stroke:Results of a 9-year cohort study in Northern California显示文摘 | Chan L Wang H Terdiman J | | 0，，： | 1 |
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