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| 1 | 子宫颈环形电切术在子宫颈上皮内瘤变治疗中的价值显示文摘目的 探讨宫颈环形电切术 (LEEP)治疗宫颈上皮内瘤变 (CIN)的效果以及宫颈标本边缘受累与否与预后的关系。方法 采用阴道镜辅助下的宫颈环形电切术 ,对 135例CIN患者进行治疗并对其疗效进行回顾性分析。结果 本研究中 ,患者中位年龄为 42岁 (18~ 6 7岁 ) ,中位妊娠次数2 2次 (0~ 8次 )。根据宫颈细胞学涂片检查结果 ,诊断为重度鳞状上皮内瘤变 (HGSIL)占 6 5 9% ,阴道镜诊断亦与上述结果类似 (75 6 % )。LEEP术后病理检查结果阴性者 7例 (5 2 % ) ;人乳头状瘤病毒(HPV)感染者 2例 (1 5 % ) ;CINⅠ级 (CINⅠ ) 15例 (11 1% ) ;HGSIL 10 8例 (80 0 % ) ,其中CINⅡ级 (CINⅡ ) 2 0例 (14 8% ) ,CINⅢ级 (CINⅢ ) 88例 (6 5 2 % ) ;宫颈微小浸润癌 3例 (2 2 % )。 78例 (5 7 8% )宫颈标本边缘病理学检查未见CIN病变 ;5 7例 (4 2 2 % )宫颈标本边缘CIN病变检测阳性或不能确定 (指由于电灼对细胞的破坏 ,影响了LEEP术后标本边缘的病理诊断 ) ,其中HGSIL 5 4例 (94 7% )。在 2 1例(15 6 % )宫颈标本边缘CIN病变检测阳性和 36例 (2 6 7% )宫颈标本边缘病理学检查不能确定患者中 ,CIN病变残留患者分别为 1例 (4 8% )和 3例 (8 3% ) ,复发患者分别为 1例 (4 8% )和 2例(5 6 % ) ;而在 78例宫颈? | 樊庆泊 Tay Sun Kuie 沈铿 | 2001 | 中华妇产科杂志2001，36，5： | 470 |
| 2 | CE/SE方法在非定常爆轰计算中的应用显示文摘建立了非定常爆轰波的理论模型。根据CE/SE方法的基本思想,推导出适合于求解二维N S方程的长方形网格的CE/SE方法。对于包含刚性反应源项的守恒方程组,将其分为两部分,其中刚性反应源项单独求解。本文以爆轰管内装填C3H8/O2预混气体为例,数值模拟管内爆轰波的传播过程以及爆轰波脱离爆轰管后流场的图谱。计算结果显示,爆轰波在管内传播时,其波系极其复杂。当爆轰波离开出口后,迅速熄灭为非反应的激波。管外不仅有激波、膨胀波的传播,而且还存在激波与涡的相互作用。数值实践表明,该CE/SE方法可以有效捕获爆轰波与激波等强间断。 | 翁春生 Tay P Gore | 2003 | 空气动力学学报2003，21，3： | 16 |
| 3 | Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia显示文摘Objective:To evaluate the activity of selected Ethiopian medicinal plants traditionally used for wound treatment against wound-causing bacteria.Methods:Samples of medicinal plants(Achyranthes aspera,Brucea antidysenteriea,Datura stramonium,Croton macrostachyus,Acokanthera xchimperi.,Phytolacca dodecandra,Milhttia ferruginea,and Solanum incanum)were extracted using absolute methanol and water and tested for their antimicrobial activities against clinical isolates and standard strains of wound-causing bacteria using agar well diffusion and micro titer plate methods.Results:Most of the plant extracts had antibacterial activities,among which Acokanthera schimperi and Brucea antidysenteriea inhibited growth of 100%and 35%of the test organisms,respectively.Methanolic extracts had higher activities compared with their corresponding aqueous extracts.The most susceptible organism to the extracts was Streptococcus pyogens while the most resistant were Escherichia coli and Proteus vulgaris.Conclusions:This finding justifies the use of the plants in wound healing and their potential activity against woundcausing bacteria.Their toxicity level and antimicrobial activity with different extraction solvents should further be studied to use them as sources and templates for the synthesis of drugs to control wound and other disease-causing bacteria. | Biruhalem Taye Mirutse Giday Abebe Animut Jemal Seid | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 12 |
| 4 | High-resolution Surface Relative Humidity Computation Using MODIS Image in Peninsular Malaysia显示文摘Forest fire is a serious disaster all over the world. The Fire Weather Index (FWI) System can be used in ap- plied forestry as a tool to investigate and manage all types of fire. Relative humidity (RH) is a very important parameter to calculate FWI. However, RH interpolated from meteorological data may not be able to provide precise and confident values for areas between far separated stations. The principal objective of this study is to provide high-resolution RH for FWI using MODIS data. The precipitable water vapor (PW) can be retrieved from MODIS using split window tech- niques. Four-year-time-series (2000-2003) of 8-day mean PW and specific humidity (Q) of Peninsular Malaysia were analyzed and the statistic expression between PW and Q was developed. The root-mean-square-error (RMSE) of Q es- timated by PW is generally less than 0.0004 and the correlation coefficient is 0.90. Based on the experiential formula between PW and Q, surface RH can be computed with combination of auxiliary data such as DEM and air temperature (Ta). The mean absolute errors of the estimated RH in Peninsular Malaysia are less than 5% compared to the measured RH and the correlation coefficient is 0.8219. It is proven to be a simple and feasible model to compute high-resolution RH using remote sensing data. | PENG Guangxiong LI Jing CHEN Yunhao Abdul Patah NORIZAN Liphong TAY | 2006 | Chinese Geographical Science2006，16，3： | 9 |
| 5 | 根除幽门螺杆菌,从合理使用抗生素做起显示文摘幽门螺杆菌根除失败的主要原因是对抗生素产生耐药。由于目前我国对治疗幽门螺杆菌的认识不统一、治疗不规范,随着抗生素的广泛使用,导致幽门螺杆菌对多种抗生素耐药率呈上升趋势,根除率下降。为了提高幽门螺杆菌的根除率,减少抗生素耐药,本文对治疗幽门螺杆菌的七种抗生素的药理机制和幽门螺杆菌对抗生素的耐药机制进行了概述,从而加深临床医生对治疗幽门螺杆菌的抗生素的认识,促使其治疗规范化。同时呼吁临床医生在治疗前进行胃黏膜细菌培养和药敏试验,从而科学规范用药,减少耐药菌株的出现,缩短治疗进程,避免资源浪费,提高幽门螺杆菌的根除率,降低消化性溃疡的复发率,延缓胃黏膜相关淋巴组织(MALT)淋巴瘤的进程,预防胃癌的产生,造福患者。 | 任小英 李雪宏 张淑贞 王湘雨 Sylvia Young Barry Marshall Alfred Chin Yen Tay | 2020 | 新发传染病电子杂志2020，5，1： | 9 |
| 6 | 自主神经功能检测对早期糖尿病自主神经功能损害的诊断价值显示文摘目的评价自主神经功能检测对早期糖尿病自主神经功能损害的诊断价值。方法50例2型糖尿病患者进行自主神经功能检查,即交感皮肤反应和心血管自主神经功能检测,并与30名健康人进行对比分析。结果糖尿病患者自主神经功能检测中交感皮肤反应,瓦氏比值和深呼吸时心率变异与对照组比较均有显著性差异(P<0.05),三者的异常率分别为70%,46%和50%;以交感皮肤反应的异常率最高,尤其以双下肢明显。立卧位血压差和冰水试验与对照组比较无显著性差异(P>0.05),其异常率分别为12%和16%。结论检测外周器官自主神经功能状态的方法中以交感皮肤反应的阳性率最高,可以作为检测早期糖尿病自主神经功能的常规筛选检查。 | 党静霞 Lena H Tay LB | 2006 | 西安交通大学学报(医学版)2006，27，2： | 7 |
| 7 | Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime显示文摘Achieving strong coupling between plasmonic oscillators can significantly modulate their intrinsic optical properties.Here,we report the direct observation of ultrafast plasmonic hot electron transfer from an Au grating array to an MoS_(2) monolayer in the strong coupling regime between localized surface plasmons(LSPs)and surface plasmon polaritons(SPPs).By means of femtosecond pump-probe spectroscopy,the measured hot electron transfer time is approximately 40 fs with a maximum external quantum yield of 1.65%.Our results suggest that strong coupling between LSPs and SPPs has synergetic effects on the generation of plasmonic hot carriers,where SPPs with a unique nonradiative feature can act as an‘energy recycle bin’to reuse the radiative energy of LSPs and contribute to hot carrier generation.Coherent energy exchange between plasmonic modes in the strong coupling regime can further enhance the vertical electric field and promote the transfer of hot electrons between the Au grating and the MoS_(2) monolayer.Our proposed plasmonic strong coupling configuration overcomes the challenge associated with utilizing hot carriers and is instructive in terms of improving the performance of plasmonic opto-electronic devices. | Hangyong Shan Ying Yu Xingli Wang Yang Luo Shuai Zu Bowen Du Tianyang Han Bowen Li Yu Li Jiarui Wu Feng Lin Kebin Shi Beng Kang Tay Zheng Liu Xing Zhu Zheyu Fang | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 8 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 9 | 胃癌预防主要策略:根除幽门螺杆菌显示文摘迄今为止,胃癌仍然是全球最常见的三大癌症之一。据报道,中国每年就有大约400 000例的新发胃癌病例报告[1]。在一些地区,虽然胃癌的发病率和死亡率已大幅下降,但胃癌的5年生存率仍低于25%。自Robin Warren教授和笔者于1984年发现幽门螺杆菌以来,1994年世界卫生组织认定其为Ⅰ类致癌物。经过多年对全世界幽门螺杆菌感染者的治疗,已经证明根除幽门螺杆菌有助于改善个体的生活质量,预防消化性溃疡病并减少胃癌[2]。 | Barry J Marshall Alfred Chin-Yen Tay | 2018 | 新发传染病电子杂志2018，3，4： | 6 |
| 10 | 可变信息板安全信息有效性研究(英文)显示文摘虽然多数先进技术应用的目的是改善路网的运行效率和安全性,但目前为止其在提高道路安全性方面的作用并不突出.例如,可以提供大容量、多方面信息的可变信息板,其设立之初的唯一目的是引导驾驶员的道路行驶.事实上,这种信息传达装置在不发布路段行驶信息的情况下,还可以发布交通安全信息以改善交通安全状况.本文选取两种禁止超速信息为研究对象,分析了该信息的发布对于驾驶员态度和路段行驶车速的影响.对近100名驾驶员进行抽样调查.测试路段为加拿大埃德蒙顿市和卡尔加里市间2号高速公路.研究结果表明,本文所选取的两种禁止超速标识对驾驶员态度和行驶车速产生的影响相对较小. | TAY Richard DE BARROS Alex | 2010 | 交通运输系统工程与信息2010，10，3： | 6 |
| 11 | Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification显示文摘Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement. | Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan | 2011 | Chinese Journal of Cancer2011，30，2： | 6 |
| 12 | Aberrant ceRNA activity drives lung cancer显示文摘 | Yvonne Tay Florian A Karreth Pier Paolo Pandolfi | 2014 | Cell Research2014，24，3： | 5 |
| 13 | 响应面法优化电炉炼钢粉尘中Zn的选择性浸出显示文摘研究浸出参数对电炉炼钢粉尘灰中选择浸出性Zn的影响,以Zn和Fe的浸出率为响应变量,以硫酸浓度、浸出温度、浸出时间和液固比为独立变量,采用基于三水平Box-Behnken的响应面法对浸出参数进行优化。对试验结果进行ANOVA分析和验证。在硫酸浓度为2.35 mol/L,浸出温度为25℃,浸出时间为56.42 min,液固比为5的条件下,可得到Zn的最大浸出率为79.09%,Fe的最小浸出率为4.08%。通过ANOVA分析表明,对Zn和Fe浸出率影响最大的因素为硫酸浓度和浸出温度。基于响应面法的模型与试验数据具有很好的一致性,Zn和Fe浸出率的相关系数分别为0.98和0.97。 | Mehmet KUL Kürsad Oguz OSKAY Mehmet SIMSIR Halit SüBüTAY Habip KIRGEZEN | 2015 | Transactions of Nonferrous Metals Society of China2015，25，8： | 5 |
| 14 | Biomaterials from the sea:Future building blocks for biomedical applications显示文摘Marine resources have tremendous potential for developing high-value biomaterials.The last decade has seen an increasing number of biomaterials that originate from marine organisms.This field is rapidly evolving.Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials.The latter are represented by chitin and chitosan,marine-derived collagen,and composites of different organisms of marine origin.The diversity of marine natural products,their properties and applications are discussed thoroughly in the present review.These materials are easily available and possess excellent biocompatibility,biodegradability and potent bioactive characteristics.Important applications of marine biomaterials include medical applications,antimicrobial agents,drug delivery agents,anticoagulants,rehabilitation of diseases such as cardiovascular diseases,bone diseases and diabetes,as well as comestible,cosmetic and industrial applications. | Mei-chen Wan Wen Qin Chen Lei Qi-hong Li Meng Meng Ming Fang Wen Song Ji-hua Chen Franklin Tay Li-na Niu | 2021 | Bioactive Materials2021，6，12： | 4 |
| 15 | 深圳地区幽门螺杆菌临床分离菌株的耐药性分析显示文摘目的探讨深圳地区幽门螺杆菌(Helicobacter pylori,Hp)临床分离菌株的耐药情况,为临床抗生素的合理选用提供实验室依据。方法2017年1月至2019年1月,对深圳市大鹏新区葵涌人民医院消化内科381例13C尿素呼气试验阳性的胃病患者行胃镜检查,采集胃窦及胃体部黏膜进行Hp培养和药物敏感试验,并对培养情况及药物敏感结果进行统计分析。结果381例患者分离培养到Hp 315株,阳性率为82.68%(315/381)。Hp对抗生素的耐药率分别为阿莫西林0(0/231)、利福平2.22%(7/315)、环丙沙星23.81%(75/315)、克拉霉素32.69%(103/315)、甲硝唑83.17%(262/315)。Hp对上述5种抗生素均敏感者有46株,敏感率14.60%(46/315),发生耐药269株,耐药率85.40%(269/315),其中单一耐药率51.43%(162/315),二重耐药率26.35%(83/315),三重耐药率7.62%(24/315)。Hp耐药率与性别、年龄有一定的关系,主要表现为男性人群Hp多重耐药率随年龄增长而增长,且老年男性人群多重耐药率明显高于老年女性人群(P<0.05)。结论深圳地区幽门螺杆菌甲硝唑耐药率极高,不适宜做为一线治疗用药;阿莫西林耐药率极低,若患者对青霉素不过敏,应当作为首选用药;男性特别是老年男性是Hp耐药及多重耐药更为严重的人群,治疗选用药物时须注意过往服药史。 | 张淑贞 李雪宏 黄海燕 陈海婷 王湘雨 Barry Marshall Alfred Tay | 2021 | 新发传染病电子杂志2021，6，2： | 4 |
| 16 | ACS Nano:新型纳米颗粒运输系统或能克服CRISPR基因编辑障碍显示文摘近日,一项刊登在国际杂志ACSNano上的研究报告中,来自马萨诸塞大学阿默斯特分校的研究人员通过研究利用纳米颗粒设计出了一种新系统能够帮助CRISPR/Cas9系统跨过细胞膜进入到细胞核中,同时还能够避免被细胞器所捕获。研究者Rubul Mout说道,CRISPR由两种组分组成,包括名为Cas9的剪刀样蛋白和名为sgRNA的RNA分子,sgRNA分子能够引导Cas9进入到靶点位置。 | Rubul Mout† Moumita Ray† Gulen Yesilbag Tonga Yi-Wei Lee Tristan Tay Kanae Sasaki Vincent M. Rotello | 2017 | 现代生物医学进展2017，17，14： | 3 |
| 17 | 胸主动脉腔内修复术后并发症的CT表现:图例说明显示文摘胸主动脉腔内修复术(TEVAR)是公认的治疗胸主动脉多种疾病的方法。接受TEVAR治疗的病人需要终生监测潜在的并发症。大部分医院都是利用CT来完成。内漏是最常见的并发症,且能被CT发现。其他的并发症(如支架引起的穿孔、远端器官的缺血)也能被CT检出。本图例说明的意义在于阐明本院所见到的TEVAR术后并发症的CT表现并强调其重要性。 | U. Pua K.H. Tay B.S. Tan M.M. Htoo M. Sebastian K. Sin 马延贺(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 18 | Heterosis in locally adapted sorghum genotypes and potential of hybrids for increased productivity in contrasting environments in Ethiopia显示文摘Increased productivity in sorghum has been achieved in the developed world using hybrids.Despite their yield advantage,introduced hybrids have not been adopted in Ethiopia due to the lack of adaptive traits,their short plant stature and small grain size.This study was conducted to investigate hybrid performance and the magnitude of heterosis of locally adapted genotypes in addition to introduced hybrids in three contrasting environments in Ethiopia.In total,139 hybrids,derived from introduced seed parents crossed with locally adapted genotypes and introduced R lines,were evaluated.Overall,the hybrids matured earlier than the adapted parents,but had higher grain yield,plant height,grain number and grain weight in all environments.The lowland adapted hybrids displayed a mean better parent heterosis(BPH) of19%,equating to 1160 kg ha-1and a 29% mean increase in grain yield,in addition to increased plant height and grain weight,in comparison to the hybrids derived from the introduced R lines.The mean BPH for grain yield for the highland adapted hybrids was 16% in the highland and 52%in the intermediate environment equating to 698 kg ha-1and 2031 kg ha-1,respectively,in addition to increased grain weight.The magnitude of heterosis observed for each hybrid group was related to the genetic distance between the parental lines.The majority of hybrids also showed superiority over the standard check varieties.In general,hybrids from locally adapted genotypes were superior in grain yield,plant height and grain weight compared to the high parents and introduced hybrids indicating the potential for hybrids to increase productivity while addressing farmers' required traits. | Taye T.Mindaye Emma S.Mace Ian D.Godwin David R.Jordan | 2016 | The Crop Journal2016，4，6： | 3 |
| 19 | 韩国动态车道控制系统中交通标识的评价研究(英文)显示文摘作为智能交通系统的一部分,在电子信息板显示的电子交通标识,由于能够为驾驶员提供清晰、准确且易于辨识的交通信息,在世界各地得到了日益广泛的应用.本文对韩国首尔市动态交通控制系统中的电子交通标识进行评价和设计.对之前研究中设计的部分标识改进,并在实际某路段的可变信息板显示试验.此外,通过部分驾驶员对这些交通标识的辨识进行分析,对不同方案进行评价,为确定最终的标识提供参考.结果表明,现有欧洲设计和韩国设计的表示交通事故的标志辨识正确率较低(分别为10%和43.5%);表示拥堵和交通事件的标志辨识正确率在45%至55%间;欧洲设计的雪天警告标志的辨识正确率为17.5%,韩国设计的雪天警告标志相对易于辨识(正确率75.5%). | TAY Richard CHOI Jaisung | 2009 | 交通运输系统工程与信息2009，9，2： | 3 |
| 20 | Helicobacter pylori eradication in Western Australia using novel quadruple therapy combinations显示文摘 | C. Y. Tay H. M. Windsor F. Thirriot W. Lu C. Conway T. T. Perkins B. J. Marshall | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 3 |
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