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| 1 | Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells显示文摘AIM: Liver fibrosis is a common pathological process of chronic liver diseases. Activation of hepatic stellate cells(HSCs) is the key issue in the occurrence of liver fibrosis. In this study, we observed the inhibitory action of rat serum containing Biejiajian oral liquid (BOL), a decoction of turtle shell, on proliferation of rat HSCs, and to explore the antihepatofibrotic mechanisms of BOL.METHODS: A rat model of hepatic fibrosis was induced by subcutaneous injection of CC14. Serum containing low,medium and high dosages of BOL was prepared respectively.Normal and fibrotic HSCs were isolated and cultured. The effect of sera containing BOL on proliferation of HSCs was determined by 3H-TdR incorporation.RESULTS: The inhibitory rate of normal rat HSC proliferation caused by 100 mL/mL sera containing medium and high dosages of BOL showed a remarkable difference as compared with that caused by colchicine (medium dosage group:34.56±4.21% vs29.12±2.85%, P<0.01; high dosage group:37.82±1.32% vs29.12±2.85%, P<0.01). The inhibitory rate of fibrotic rat HSC proliferation caused by 100 mL/L serum containing medium and high dosages of BOL showed a remarkable difference as compared with that caused by colchicine (medium dosage group: 51.31_+3.14% vs 38.32_+2.65%,P<0.01; high dosage group: 60.15_+5.36% vs38.32_+2.65%,P<0.01). The inhibitory rate of normal rat HSC proliferation caused by 100 mL/L and 200 mL/L sera containing a medium dosage of BOL showed a significant difference as compared with that caused by 50 mL/L (100 mL/L group: 69.02±9.96%vs 50.82±9.28%, P<0.05; 200 mL/L group: 81.78±8.92%vs50.82±9.28%, P<0.01). The inhibitory rate of fibrotic rat HSC proliferation caused by 100 mL/L and 200 mL/L sera containing a medium dosage of BOL showed a significant difference as compared with that caused by 50 mL/L (100 mL/L group:72.19±10.96% vs 61.38±7.16%, P<0.05; 200 mL/L group:87.16±8.54% vs 61.38±7.16%, P<0.01).CONCLUSION: Rat serum containing BOL can inhibit proliferation of rat HSCs, and the inhibition depends on the dosage and concentration of BOL. The inhibitory effect on HSC proliferation is one of the main anti-hepatofibroticmechanisms of BOL. | LiYao Zhen-MinYao HengWeng Ge-PingZhao Yue-JunZhou TaoYu | 2004 | World Journal of Gastroenterology2004，10，13： | 12 |
| 2 | Functional neuroimaging of e xtraversion-introversion显示文摘Neuroimaging techniques such as functional magnetic resonance imaging and positron emission tomography have provided an unprecedented neurobiological perspective for research on personality traits. Evidence from task-related neuroimaging has shown that extraversion is associated with activations in regions of the anterior cingulate cortex,dorsolateral prefrontal cortex,middle temporal gyrus and the amygdala. Currently,resting-state neuroimaging is being widely used in cognitive neuroscience. Initial exploration of extraversion has revealed correlations with the medial prefrontal cortex,anterior cingulate cortex,insular cortex,and the precuneus. Recent research work has indicated that the long- range temporal dependence of the resting-state spontaneous oscillation has high test-retest reliability. Moreover,the long-range temporal dependence of t he resting-state networks is highly correlated with personality traits,and this can be used for the prediction of extraversion. As the long-range temporal dependence refl ects real-time information updating in individuals,this method may provide a new approach to research on personality traits. | Xu Lei Tianliang Yang Taoyu Wu | 2015 | Neuroscience Bulletin2015，31，6： | 4 |
| 3 | Species richness and composition of shrub-encroached grasslands in relation to environmental factors in northern China显示文摘Aims Shrub encroachment has taken place in many of China’s northern grasslands.This study attempts to answer the following questions:which plant communities are present in these shrub-encroached grasslands(SEGs)?What are the species richness and composition of these communities?Which environmental factors determine the spatial distribution thereof?Methods We investigated the community characteristics of 255 SEG plots with a size of 20 m×20 m at 69 locations across grasslands in northern China.In each plot,paired 1-m^(2) quadrats were estab-lished within shrub patches and the neighbouring grassy matrix to record herb species composition.The quantitative character-istics(abundance,coverage and height)of herbs were meas-ured in 0.25-m2 subquadrats,and soil samples were collected in the quadrats.Two-way indicator species analysis(TWINSPAN),detrended canonical analysis(DCA)and canonical correspond-ence analysis(CCA)were used for community clustering and ordination.Important Findings The DCA and TWINSPAN results suggested that the SEGs in northern China can be divided into six community types:Potentilla fruticosa+Carex atrofusca,Spiraea hypericifolia+Festuca ovina,Caragana acanthophylla+Stipa sareptana,Caragana microphylla+Leymus chinensis,Caragana microphylla+Stipa klemenzii and Caragana tibetica+Cleistogenes songorica.At a regional scale,climate and soil nutrients controlled the spatial patterns of species richness and community composition of the SEGs in northern China.Temperature exerted a negative impact,whereas precipitation and nutrients had positive effects on species richness.Among the environmental factors used,climate was the major controller of the variations in commu-nity structure.These results provide new insights into the community composition of SEGs in China and enrich the global dataset of SEGs. | Luhong Zhou Haihua Shen Leiyi Chen He Li Pujin Zhang Xia Zhao Taoyu Liu Shangshi Liu Aijun Xing Huifeng Hu Jingyun Fang | 2019 | Journal of Plant Ecology2019，12，1： | 3 |
| 4 | Immunotoxins and Cancer Therapy显示文摘In the past decade, an increased amount of clinically-oriented research involving immunotoxins has been published.Immunotoxins are a group of artificially-made cytotoxic molecules targeting cancer cells. These molecules composed of a targeting moiety, such as a ligand or an antibody, linked to toxin moiety, which is a toxin with either truncated or deleted cell-binding domain that prevents it from binding to normal cells. Immunotoxins can be divided into two categories: chemically conjugated immunotoxins and recombinant ones. The immunotoxins of the first category have shown limited efficacy in clinical trials in patients with hematologic malignancies and solid tumors. Within the last few years, single-chain immunotoxins provide enhanced therapeutic efficacy over conjugated forms and result in improved antitumor activity. In this review, we briefly illustrate the design of the immunotoxins and their applications in clinical trials. Cellular & Molecular Immunology. 2005;2(2):106-112. | ZhengLi TaoYu PingZhao JieMa | 2005 | Cellular & Molecular Immunology2005，2，2： | 2 |
| 5 | Experimental studyof precision-woven fabrics for oil-in-water emulsion coalescence op-erating conditions and oil Saturation显示文摘 | Zhang Luhong Zhu Taoyue Sun Yongli | 2015 | Journal of Dispersion Sci-ence and Technology2015，36，： | 1 |
| 6 | Confocal endomicroscopy for in vivo detection of microvascular architecture in normal and malignant lesions of upper gastrointestinal tract显示文摘 | HongLiu Yan‐QingLi TaoYu You‐AnZhao Jian‐PingZhang Jian‐NaZhang Yu‐TingGuo Xiang‐JunXie Ting‐GuoZhang Paul VDesmond | 2007 | Journal of Gastroenterology and Hepatology2007，，： | 1 |
| 7 | Study on kinetics and electrochemical properties of low-Co AB5-type alloys for high-power Ni/MH battery显示文摘 | Zhang Wencui Hao Jiansheng Bai Taoyu | 2009 | Electro2009，54，4： | 1 |
| 8 | “Bottom‐Up” Embedding of the J?rgensen–Hayashi Catalyst into a Chiral Porous Polymer for Highly Efficient Heterogeneous Asymmetric Organocatalysis显示文摘 | Chang AnWang Zhi KunZhang TaoYue Ya LeiSun LeiWang Wei DavidWang YuanZhang ChongLiu WeiWang | 2012 | Chem. Eur. J2012，，22： | 1 |
| 9 | Circulating Toll‐like receptor (TLR) 2, TLR4, and regulatory T cells in patients with chronic hepatitis C显示文摘 | JIU‐PINGWANG YEZHANG XINWEI JUNLI XUE‐PINGNAN HAI‐TAOYU YULI PING‐ZHONGWANG XUE‐FANBAI | 2010 | APMIS2010，，4： | 1 |
| 10 | Confocal laser endomicroscopy for diagnosis of Helicobacter pylori infection: A prospective study显示文摘 | RuiJi Yan‐QingLi Xiao‐mengGu TaoYu Xiu‐LiZuo Cheng‐junZhou | 2010 | Journal of Gastroenterology and Hepatology2010，，4： | 1 |
| 11 | Performance model and evaluation on geographic-based routing显示文摘 | LI Taoyu ZHU Yuncheng XU Ke | | 0，，02： | 1 |
| 12 | Confocal endomicroscopy for in vivo detection of microvascular architecture in normal and malignant lesions of upper gastrointestinal tract显示文摘 | HongLiu Yan‐QingLi TaoYu You‐AnZhao Jian‐PingZhang Jian‐NaZhang Yu‐TingGuo Xiang‐JunXie Ting‐GuoZhang Paul VDesmond | 2007 | Journal of Gastroenterology and Hepatology2007，，1： | 1 |
| 13 | Present status and future potential of enhancing bone healing using nanotechnology显示文摘 | George Stylios Taoyu Wan Peter Giannoudis | 2007 | Injury2007，，1： | 1 |
| 14 | Confocal laser endomicroscopy for diagnosis of Helicobacter pylori infection: A prospective study显示文摘 | RuiJi Yan‐QingLi Xiao‐mengGu TaoYu Xiu‐LiZuo Cheng‐junZhou | 2010 | Journal of Gastroenterology and Hepatology2010，，4： | 1 |
| 15 | Advancing the pressure sensing performance of conductive CNT/PDMS composite film by constructing a hierarchical-structured surface显示文摘Flexible pressure sensors have attracted wide attention due to their applications to electronic skin,health monitoring,and human-machine interaction.However,the tradeoff between their high sensitivity and wide response range remains a challenge.Inspired by human skin,we select commercial silicon carbide sandpaper as a template to fabricate carbon nanotube(CNT)/polydimethylsiloxane(PDMS)composite film with a hierarchical structured surface(h-CNT/PDMS)through solution blending and blade coating and then assemble the h-CNT/PDMS composite film with interdigitated electrodes and polyurethane(PU)scotch tape to obtain an h-CNT/PDMS-based flexible pressure sensor.Based on in-situ optical images and finite element analysis,the significant compressive contact effect between the hierarchical structured surface of h-CNT/PDMS and the interdigitated electrode leads to enhanced pressure sensitivity and a wider response range(0.1661 kPa^(-1),0.4574 kPa^(-1)and 0.0989 kPa^(-1)in the pressure range of 0–18 kPa,18–133 kPa and 133–300 kPa)compared with planar CNT/PDMS composite film(0.0066 kPa^(-1)in the pressure range of 0–240 kPa).The prepared pressure sensor displays rapid response/recovery time,excellent stability,durability,and stable response to different loading modes(bending and torsion).In addition,our pressure sensor can be utilized to accurately monitor and discriminate various stimuli ranging from human motions to pressure magnitude and spatial distribution.This study supplies important guidance for the fabrication of flexible pressure sensors with superior sensing performance in next-generation wearable electronic devices. | Ye Zhao Taoyu Shen Minyue Zhang Rui Yin Yanjun Zheng Hu Liu Hongling Sun Chuntai Liu Changyu Shen | 2023 | Nano Materials Science2023，5，4： | 1 |
| 16 | Ultrastable MOF-based foams for versatile applications显示文摘Metal-organic frameworks(MOFs)are attractive for promising applications but plagued by difficult recovery and deployment due to their intrinsic nano/micro powder nature.Although significant efforts have been made to develop separable solid matrixes for MOF supporting,the poor loading stability and durability of MOFs still challenge their engineering applications.Here,we present a facile and effective approach to fabricate MOF-based melamine foams(MFs)(denoted as MOFiths)with ultrahigh loading stability and operation stability,easy separation,and high-efficient performance for versatile robust applications.By adopting our approach,numbers of typical fragile MOFs characterized with wide ranges of particle size(from~nm to~μm)can be precisely incorporated into MFs with controllable loading ratios(up to~1,600%).Particularly,the produced MOFiths show excellent capacities for the highly effective and durable water purifications and acetalization reactions.100%of organic pollutants can be rapidly destructed within 10 min by MOFiths initiated Fenton or catalytic ozonation processes under five successive cycles while the maximum adsorption capacity of MOFiths toward Pb(II),Cd(II),and Cu(II)reaches to 422,222,and 105 mg·g^(-1),respectively.This study provides a critical solution to substantially facilitate the engineering applications of MOFs for long-term use in practice. | Qian Hu Licong Xu Kaixing Fu Feichao Zhu Taoyu Yang Tao Yang Jinming Luo Minghua Wu Deyou Yu | 2022 | Nano Research2022，15，4： | 1 |
| 17 | A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex显示文摘Dear Editor,COVID-19(Coronavirus Disease 2019)is a disease caused by the single-stranded sense RNA virus SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),which has caused a global public health crisis.1 However,so far no effective serum marker has been found as a biomarker for COVID-19 diagnosis,except that viral nucleic acid detection is an effective evidence of SARS-CoV-2 infection. | Fugang Duan Yifan Wang Taoyu Chen Zhu Zhu Meng Yu Hui Dai Shangen Zheng Yinying Lu Tingting Li Xiaoyan Qiu | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 18 | Highly Conductive Zinc-Tin-Oxide Buffer Layer for Inverted Polymer Solar Cells显示文摘Thin-films of Zinc Tin Oxide(ZTO)with an extremely high charge carrier mobility and superior optical transmittance are synthesized using a simple solution method.These ZTO films have been systematically studied for the application in inverted polymer solar cells(PSCs).The Hall effects measurements show that the charge | Leiming Yu Deying Luo Hai Wang Taoyu Zou Li Luo Zhenfang Qiao Yiji Yang Jianhong Zhao Taoling He Zhu Liu Zheng-Hong Lu | 2016 | 功能材料信息2016，13，2： | 0 |
| 19 | Analysis and Study of Buffer Overflow显示文摘 | Liu Sidong Zen TaoYu Yongquan | 2009 | 中国电子商情(通信市场)2009，，2： | 0 |
| 20 | High-throughput experimental methods for investigating biomolecular condensates显示文摘Background:The concept of biomolecular condensate was put forward recently to emphasize the ability of certain cellular compartments to concentrate molecules and comprise proteins and nucleic acids with specific biological functions,from ribosome genesis to RNA splicing.Due to their unique role in biological processes,it is crucial to investigate their compositions,which is a primary determinant of condensate properties.Results:Since a wide range of macromolecules comprise biomolecular condensates,it is necessary for researchers to investigate them using high-throughput methodologies while low-throughput experiments are not efficient enough.These high-throughput methods usually purify interacting protein libraries from condensates before being scanned in mass spectrometry.It is possible to extract organelles as a whole for specific condensates for further analysis,however,most condensates do not have a distinguishable marker or are sensitive to shear force to be extracted as a whole.Affinity tagging allows a comprehensive view of interacting proteins of target molecule yet only proteins with strong bonds may be pulled down.Proximity labeling serves as a complementary method to label more dynamic proteins with weaker interactions,increasing sensitivity while decreasing specificity.Image-based fluorescent screening takes another path by scanning images automatically to illustrate the condensing state of biomolecules within membraneless organelles,which is a unique feature unlike the previous mass spectrometry-based methods.Conclusion:This review presents a rough glimpse into high-throughput methodologies for biomolecular condensate investigation to encourage usage of bioinformatic tools by researchers in relevant fields. | Taoyu Chen Qi Lei Minglei Shi Tingting Li | 2021 | Quantitative Biology2021，9，3： | 0 |
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