| 1 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 3 | Photon-counting distributed free-space spectroscopy显示文摘Spectroscopy is a well-established nonintrusive tool that has played an important role in identifying and quantifying substances,from quantum descriptions to chemical and biomedical diagnostics.Challenges exist in accurate spectrum analysis in free space,which hinders us from understanding the composition of multiple gases and the chemical processes in the atmosphere.A photon-counting distributed free-space spectroscopy is proposed and demonstrated using lidar technique,incorporating a comb-referenced frequency-scanning laser and a superconducting nanowire single-photon detector.It is suitable for remote spectrum analysis with a range resolution over a wide band.As an example,a continuous field experiment is carried out over 72 h to obtain the spectra of carbon dioxide(CO_(2))and semi-heavy water(HDO,isotopic water vapor)in 6 km,with a range resolution of 60 m and a time resolution of 10 min.Compared to the methods that obtain only column-integrated spectra over kilometer-scale,the range resolution is improved by 2-3 orders of magnitude in this work.The CO_(2)and HDO concentrations are retrieved from the spectra acquired with uncertainties as low as±1.2%and±14.3%,respectively.This method holds much promise for increasing knowledge of atmospheric environment and chemistry researches,especially in terms of the evolution of complex molecular spectra in open areas. | Saifen Yu Zhen Zhang Haiyun Xia Xiankang Dou Tengfei Wu Yihua Hu Manyi Li Mingjia Shangguan Tianwen Wei Lijie Zhao Lu Wang Pu Jiang Chengjun Zhang Lixing You Leigang Tao Jiawei Qiu | 2021 | Light(Science & Applications)2021，10，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员