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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 3 | Radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina RPC structures as integrated solar thermochemical reactor显示文摘This paper investigated radiative heat transfer and thermal characteristics of Fe-based oxides coated SiC and Alumina reticulated porous ceramic structures as integrated solar thermochemical reactor.High-flux solar radiation absorption and axial temperature distribution in the ceramic foams reactor were analyzed by adopting surface-to-surface radiation model coupled to the P1approximation for radiation heat transfer.The radiative heat transfer and thermal characteristics of different foam-type RPC structures,including SiC,CeO_2,FeAl_2O_4,NiFeAlO_4,Fe_3O_4/SiC,and NiFe_2O_4/SiC were evaluated.The mass flow rate and foam structural parameters,including the permeability,pore mean cell size,and extinction coefficients have significantly affected the axial temperature distribution,pressure drop,heat transfer,and fluid flow.Integrated porous structure to the solar receiver could maximize the incorporation of redox powder in the reacting medium,lower the pressure drop,and enhance the thermal performance of the thermochemical reacting system.SiC structure was the candidate materials in the case where more heat flux and high axial temperature distribution is needed.However,Fe-based oxide coated Al_2O_3structure could be considered regarding the heat transfer enhancement along with the catalyst activity of oxygen carriers for solar thermochemical reacting system performance. | GUENE LOUGOU Bachirou SHUAI Yong PAN RuMing CHAFFA Gédéon AHOUANNOU Clément ZHANG Hao TAN HePing | 2018 | Science China(Technological Sciences)2018，61，12： | 2 |
| 4 | Human metabolic sydrome resulting from dominant-negative mutation in the nuclear receptor peroxisome proliferator-activated recepter-gamma显示文摘 | Savage DB Tan GD Acerini CL | 2003 | Diabetes2003，52，4： | 1 |
| 5 | Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer显示文摘 | Tan WS Tang CL Shi L | 2009 | Br J Surg2009，96，5： | 1 |
| 6 | Long-term colehieine for recalcitrant palmoplantar pustulosis: treatment outcome in 3 patients 显示文摘 | Wong SS Tan KC Goh CL | 2001 | Cutis2001，68，9： | 1 |
| 7 | Overexpression of interleukin13 induces minimal-change-like nephropathy in rats显示文摘 | Lai KW Wei CL Tan LK | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 8 | Tumor suppressor or onco- gene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression 显示文摘 | Bellanger S Tan CL Xue YZ | 2011 | Am J Cancer Res2011，1，3： | 1 |
| 9 | Cerebellar neurodegeneration in the absence of microRNAs显示文摘 | Schaefer A O\'Carroll DON Tan CL | 2007 | Journal of Experimental Medicine2007，204，7： | 1 |
| 10 | Criticai incident in pediatric anaesthesia:an audit of 10000 anaesthetics in Singapore显示文摘 | Tay CL Tan GM Ng SB | 2001 | Paediatr Anaesth2001，11，6： | 1 |
| 11 | Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer 显示文摘 | Tan WS Tang CL Shi L | 2009 | Br J Surg2009，96，5： | 1 |
| 12 | The degrees to which Iran- strochanterie rotational estcotomy moves the region of osteo- necrotic femoral head out of the weight-bearing area as evaluated by computer simulation 显示文摘 | Chen WP Tai CL Tan CF | 2005 | Clin Biomech ( Bris- tol Avoll)2005，20，1： | 1 |
| 13 | Chronic autoimmune urticaria: where we stand?显示文摘 | Goh CL Tan KT | 2009 | Indian J Dermatol2009，54，3： | 1 |
| 14 | The cumulative embryo score: a predictive embryo scoring technique to select the op timal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme显示文摘 | Steer CV Mills CL Tan SL | 1992 | Hum Reprod1992，7，1： | 1 |
| 15 | The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme显示文摘 | Steer CV Mills CL Tan SL | 1992 | Hum Reprod1992，7，1： | 1 |
| 16 | Collaborative new product development en- vironments : implications for supply chain management 显示文摘 | Tan CL Traeey M | 2007 | Journal of Supply Chain Management2007，43，3： | 1 |
| 17 | Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome prolife rator-actived receprgamma 显示文摘 | Savage DB Tan GD Acerini CL | 2004 | Diabetes2004，52，7： | 1 |
| 18 | Meta-analysis of defunctioni stomas in low anterior resection for rectal cancer显示文摘 | Tan WS Tang CL Shi L | | 0，，05： | 1 |
| 19 | RNA interference against enterovirus 71 infection 显示文摘 | Sire AC Luhur A Tan TM Chow VT Poh CL | 2005 | Virology2005，341，1： | 1 |
| 20 | The pattern and profile of alopecia areata in Singapore-a study of 219 Asians显示文摘 | Tan E Tay YK Goh CL | 2002 | Int J Dermatol2002，41，11： | 1 |
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