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    题名 作者 年代 出处 被引量
1The C_2H_2 -type Zinc Finger Protein ZFP182 is Involved in Abscisic Acid-Induced Antioxidant Defense in Rice显示文摘C2H2 -type zinc finger proteins (ZFPs) are thought to play important roles in modulating the responses of plants to drought, salinity and oxidative stress. However, direct evidence is lacking for the involvement of these ZFPs in abscisic acid (ABA)-induced antioxidant defense in plants. In this study, the role of the rice (Oryza sativa L. sub. japonica cv. Nipponbare) C 2 H 2 -type ZFP ZFP182 in ABA-induced antioxidant defense and the relationship between ZFP182 and two rice MAPKs, OsMPK1 and OsMPK5 in ABA signaling were investigated. ABA treatment induced the increases in the expression of ZFP182, OsMPK1 and OsMPK5, and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in rice leaves. The transient gene expression analysis and the transient RNA interference (RNAi) analysis in protoplasts showed that ZFP182, OsMPK1 and OsMPK5 are involved in ABA-induced up-regulation in the activities of SOD and APX. Besides, OsMPK1 and OsMPK5 were shown to be required for the up-regulation in the expression of ZFP182 in ABA signaling, but ZFP182 did not mediate the ABA-induced up-regulation in the expression of OsMPK1 and OsMPK5. These results indicate that ZFP182 is required for ABA-induced antioxidant defense and the expression of ZFP182 is regulated by rice MAPKs in ABA signaling.Hong Zhang Lan Ni Yanpei Liu Yunfei Wang Aying Zhang Mingpu Tan Mingyi Jiang 2012Journal of Integrative Plant Biology2012,54,7:23
2Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration显示文摘Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses.Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials.However,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory.Currently,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling pathways.Properties of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal system.Based on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune reprogramming.Here,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune environment.Such strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application.Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai Yulei Huang Xiaodan Chen Lijia Huang Jiali Tan 2020Regenerative Biomaterials2020,7,3:22
3Nitric Oxide Reduces Hydrogen Peroxide Accumulation Involved in Water Stress-induced Subcellular Anti-oxidant Defense in Maize Plants显示文摘Nitric oxide (NO) is a bioactive molecule involved in many biological events, and has been reported as pro-oxidant as well as anti-oxidant in plants. In the present study, the sources of NO production under water stress, the role of NO in water stress-induced hydrogen peroxide (H2O2) accumulation and subcellular activities of anti-oxidant enzymes in leaves of maize (Zea mays L.) plants were investigated. Water stress induced defense increases in the generation of NO in maize mesphyll cells and the activity of nitric oxide synthase (NOS) in the cytosolic and microsomal fractions of maize leaves. Water stress-induced defense increases in the production of NO were blocked by pretreatments with inhibitors of NOS and nitrate reductase (NR), suggesting that NO is produced from NOS and NR in leaves of maize plants exposed to water stress. Water stress also induced increases in the activities of the chloroplastic and cytosolic anti-oxidant enzymes superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR), and the increases in the activities of anti-oxidant enzymes were reduced by pretreatments with inhibitors of NOS and NR. Exogenous NO increases the activities of water stress-induced subcellular anti-oxidant enzymes, which decreases accumulation of H2O2. Our results suggest that NOS and NR are involved in water stress-induced NO production and NOS is the major source of NO. The potential ability of NO to scavenge H2O2 is, at least in part, due to the induction of a subcellular anti-oxidant defense.Jianrong Sang Mingyi Jiang Fan Lin Shucheng Xu Aying Zhang Mingpu Tan 2008Journal of Integrative Plant Biology2008,50,2:15
4Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H 2006第二军医大学学报2006,27,5:14
5Diversity and high nitrogenase activity of endophytic diazotrophs isolated from Oryza rufipogon Griff.显示文摘Diversity and nitrogenase activity of endophytic diazotrophs colonized in the wild rice Oryza rufipogon Griff grown in Boluo, Huilai County in Guangdong Province and Lingshui County in Hainan Province were studied. Thirty-seven isolates obtained from Oryza rufipogon were identified as putative endophytic nitrogen-fixing bacteria by ARA (acetylene reduction assay) test and further confirmed by PCR amplification of nifH gene fragments. All obtained strains have ARA activity and the same sized nifH gene fragments. Above the similarity level of 80%, the obtained isolates were assigned as Group Ⅰ to Ⅷ by the clustering of IS-PCR fingerprints. The SDS-PAGE whole-cell protein patterns were similar to those of IS-PCR fingerprints. Components and contents of fatty acid methyl esters (FAMEs) were used to differentiate the representative strains (Ls13, Ls8, BL1, BL12, HL6, Ls4) from Group Ⅰ to Group Ⅵ. The six representative strains showed significant difference in contents and components of cellular fatty acid methyl ester. 16S rDNA sequencing analysis showed that strains of Group Ⅰ to Ⅶ were located in Enterobacteraceae (γ-proteobacteria). Strains of Group Ⅰ and Group II were closely related to Klebsiella sp.; Strain Ls8 of Group Ⅱ was a little far away from the genus of Pantoea (homology level 96% with Pantoea agglomerans), which may represent a new species or genus in Enterobacteraceae; Strains of Groups IV and V belonged to different Enterobacter sp.; Strain Ls4 and Ls 9 representing Group Ⅵ were close to Citrobacter amalonaticus with 98% sequence similarity; Strain Ls15 of Group Ⅶ showed 98% sequence identity with Pantoea sp.; Strains of Group Ⅷ were assigned to the genus Ideonella (β-proteobacteria). Based on the above results, endophytic diazotrophs isolated from O. rufipogon showed great diversity and some diazotrophs showed high nitrogenase activity with 42.52 μmol/mL·h C2H4. Inoculation to rice tests indicated that the isolated endophytic diazotrophs significantly promoted the rice growth.TAN ZhiYuan PENG GuiXiang XU PeiZhi AI ShaoYing TANG ShuanHu ZHANG GuoXia ZENG FengYun 2009Chinese Science Bulletin2009,54,16:14
6OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice显示文摘Ca2+ 和 calmodulin (凸轮) 被看了抗氧化剂防卫到在 abscisic 酸(骆驼毛的织物) 的一个重要角色导致了的玩。然而, Ca2+/CaM-dependent 蛋白质 kinase (CCaMK ) 是否涉及这个过程,是未知的。在现在的学习,米饭 CCaMK 的角色, OsDMI3,在导致骆驼毛的织物的抗氧化剂,防卫在米饭(Oryza sativa ) 的叶子被调查植物。有骆驼毛的织物, H2O2,和聚乙烯乙二醇(木钉) 的处理导致了 OsDMI3 和 OsDMI3 的活动的表示,并且 H2O2 在水应力下面为表示和 OsDMI3 的活动的导致骆驼毛的织物的增加被要求。Subcellular 本地化分析证明 OsDMI3 位于原子核,细胞质,和血浆膜。在米饭原物和在米饭原物的 OsDMI3 的 silencing 显示出的 RNA 干扰(RNAi ) 的 OsDMI3 的短暂表示的分析那 OsDMI3 为表示和 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的活动的导致骆驼毛的织物的增加被要求。进一步,氧化损坏由木钉的更高的集中导致了, H2O2 在 OsDMI3 的异种被加重。而且,在原物和 OsDMI3 的异种的 OsDMI3 的 RNAi silencing 的分析证明 H2O2 累积的高水平要求在骆驼毛的织物发信号的 OsDMI3 激活,而是起始的 H2O2 生产导致了由骆驼毛的织物不依赖于在米饭植物的叶子的 OsDMI3 的激活。我们的数据表明 OsDMI3 是在在米饭的导致骆驼毛的织物的抗氧化剂防卫的一个重要部件。Ben Shi Lan Ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang 2012Molecular Plant2012,5,6:10
7An extrapolation approach for aeroengine's transient control law design显示文摘Transient control law ensures that the aeroengine transits to the command operating state rapidly and reliably.Most of the existing approaches for transient control law design have complicated principle and arithmetic.As a result,those approaches are not convenient for application.This paper proposes an extrapolation approach based on the set-point parameters to construct the transient control law,which has a good practicability.In this approach,the transient main fuel control law for acceleration and deceleration process is designed based on the main fuel flow on steady operating state.In order to analyze the designing feature of the extrapolation approach,the simulation results of several different transient control laws designed by the same approach are compared together.The analysis indicates that the aeroengine has a good performance in the transient process and the designing feature of the extrapolation approach conforms to the elements of the turbofan aeroengine.Kong Xiangxing Wang Xi Tan Daoliang He Ai Liu Yue 2013Chinese Journal of Aeronautics2013,26,5:8
8Survey of coverage,strategy and cost of hepatitis B vaccination in rural and urban areas of China显示文摘INTRODUCTIONSomestudiesdemonstratedthatHBsAgandantiHBcpositiveratesoftheimmunizedpopulationsafterhepatitisB(HB)vaccination...ZENG Xian Jia 1, YANG Gong Huan 2, LIAO Su Su 1, CHEN Ai Ping 2, TAN Jian 2, HUANG Zheng Jing 2 and LI Hui 1 1999World Journal of Gastroenterology1999,5,4:8
9Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression显示文摘运动不足是胆石疾病的普通症状,它被空隙的象 Cajal 一样房间(ICLC ) 的损失在胆囊伴随。Ursodeoxycholic 酸(UDCA ) 广泛地在治疗胆石疾病被使用,并且除了它溶解胆石的能力显示出 anti-apoptotic 和反煽动性的效果。在这研究,我们与胆石在畿尼猪在 ICLC 上调查了 anti-apoptotic 和 UDCA 的反煽动性的效果。畿尼猪被喂为 8 个星期到的一本高胆固醇的食谱导致胆石的形成。一组动物被管理 UDCA (在跟随 553 的 consultation.ResultsA 总数的临床的管理的一个变化请教的 50 mgith 为 268 个婴儿被执行(gestational 年龄:在到控制的 CP 和 RAP.ResultsCompared 之间的 27ffect QOL 预言者(51.0ook 建筑群产品,它证明 GaoFen-3 是 SAR 图象在有另外的二幅 C 乐队 SAR 图象和它 3.5 dB 的 RR 会系统设计的一样的优秀水平。然后,这些 thr 的反散射系数??Jiang-fan WAN Shi-feng CHU Xin ZHOU Yue-ting LI Wen-bin HE Feng TAN Piao LUO Qi-di AI Qi WANG Nai-hong CHEN 2018Acta Pharmacologica Sinica2018,39,9:8
10The preoperative serum cystatin-C as an independent prognostic factor for survival in upper tract urothelial carcinoma显示文摘Cystatin-C(Cys-C)has been reported as a valuable prognostic biomarker in various malignancies.However,its effect on upper tract urothelial carci noma(UTUC)patie nts has not bee n investigated before.Thus,to explore the impact of Cys-C on survival outcomes in patients undergoing radical nephroureterectomy(RNU),a total of 538 patients with UTUC who underwent RNU between 2005 and 2014 in our center(West China Hospital,Chengdu,China)were included in this study.Kaplan-Meier method and Cox regressi on an a lyses were performed to assess the relationship betwee n Cys-C and survival outcomes using SPSS versi on 22.0.The cutoff value of Cys-C was set as 1.4 mg I1 using the receiver operating characteristic(ROC)curves and Youden index.The mean age of patients included was 66.1±11.1 years,and the media n follow-up durati on was 38(interquartile ran ge:19-56)mon ths.Overall,162(30.1%)patients had elevated Cys-C,and they were much older and had worse renal function than those with Cys-C<1.4 mg I^-1(both P<0.001).Meanwhile,Kaplan-Meier analysis revealed that the group with elevated Cys-C had worse cancer-specific survival(CSS,P=0.001),disease recurrence-free survival(RFS,P=0.003),and overall survival(OS,P<0.001).Multivariable Cox analysis suggested that the elevated Cys-C was identified as an independent prognostic predictor of CSS(hazard ratio[HR]:1.997,95%confidential interval[CI]:1.331-2.996),RFS(HR:1.429,95%CI:1.009-2.023),and OS(HR:1.989,95%CI:1.366-2.896).In conclusion,our result revealed that the elevated preoperative serum Cys-C was significantly associated with worse outcomes in UTUC patients undergoing RNU.Ping Tan Ming Shi Jie Chen Hang Xu Nan Xie Huan Xu Yong Jiang Jian-Zhong Ai Liang-Ren Liu Lu Yang Qiang Wei 2019Asian Journal of Andrology2019,21,2:7
11Cross-talk between calcium-calmodulin and nitric oxide in abscisic acid signaling in leaves of maize plants显示文摘用药理学和生物化学的途径,在过氧化氢( H ( 2 ) O ( 2 ))之间的发信号的小径,钙( Ca (2+)) -calmodulin (凸轮),并且氮的氧化物(没有)在 abscisic 酸(骆驼毛的织物),导致的抗氧化剂防卫在玉米( Zea mays L.)的叶子被调查植物。有骆驼毛的织物, H (2 ) O (2 ) ,和 CaCl (2 ) 的处理在产生导致了增加不,在玉米叶肉房间和氮的氧化物的活动,在 cytosolic 和玉米的 microsomal 部分的 synthase (NOS ) 离开。然而,如此的增加被预告的处理与 Ca (2+) 禁止者和凸轮对手堵住。同时, Ca (2+)导致了的有也压制的二个 NOS 禁止者的预告的处理在另一方面在号码的生产增加,有骆驼毛的织物和 NO 施主钠 nitroprusside ( SNP )的处理也在叶肉房间的原物并且在 calmodulin 的表示在 cytosolic Ca (2+)的集中导致了增加 1 ( CaM1 )基因和在玉米的叶子的凸轮的内容种,并且骆驼毛的织物导致的增加被预告的处理减少与一没有 scavenger 和一个 NOS 禁止者。而且,抗氧化剂基因的表示的 导致SNP 的增加超级氧化物 dismutase 4 ( SOD4 ), cytosolic ascorbate 过氧化物酶(帽子 X ),并且谷胱甘肽 reductase 1 ( GR1 )并且 chloroplastic 和 cytosolic 抗氧化剂酶的活动被预告的处理与 Ca (2+)禁止者和凸轮对手逮捕。我们的结果建议那个 Ca (2+) 凸轮没有生产在上游、下游的功能,主要来自 NOS,导致骆驼毛的织物并且 H (2 ) O (2 ) 在玉米植物的叶子导致了抗氧化剂防卫。Jianrong Sang Aying Zhang Fan Lin Mingpu Tan Mingyi Jiang 2008Cell Research2008,18,5:6
12Experimental investigation of propagation mechanisms and fracture morphology for coalbed methane reservoirs显示文摘Fracture propagation mechanisms in coalbed methane(CBM) reservoirs are very complex due to the development of the internal cleat system. In this paper, the characteristics of initiation and propagation of hydraulic fractures in coal specimens at different angles between the face cleat and the maximum horizontal principal stress were investigated with hydraulic fracturing tests. The results indicate that the interactions between the hydraulic fractures and the cleat system have a major effect on fracture networks. 'Step-like'' fractures were formed in most experiments due to the existence of discontinuous butt cleats. The hydraulic fractures were more likely to divert or propagate along the butt cleat with an increase in the angles and a decrease in the horizontal principal stress difference. An increase in the injection rate and a decrease in the fracturing fluid viscosity were more conducive to fracture networks. In addition, the influence on fracture propagation of the residual coal fines in the wellbore was also studied. The existence of coal fines was an obstacle in fracturing, and no effective connection can be formed between fractures. The experimental investigation revealed the fracture propagation mechanisms and can provide guidance for hydraulic fracturing design of CBM reservoirs.Chi Ai Xiao-Xuan Li Jun Zhang Dan Jia Wen-Jing Tan 2018Petroleum Science2018,15,4:5
13Mass change study on Arctic glacier Pedersenbreen, during 1936-1990-2009显示文摘Pedersenbreen is a small polythermal valley glacier, located in Svalbard, which has been one of the two glaciers monitored by Chinese Arctic expedition members since 2004. This study estimates its area and volume and analyzes its change during 1936-1990-2009, using field collected GPS/GPR data in 2009 and historical topographic maps published by the Norwegian Polar Institute. We have found that Pedersenbreen is just like many other valley glaciers in Svalbard, having experienced a significant recession since the end of Little Ice Age in the early 20th century. The glacier tongue has retreated more than 0.6 km, while ice volume has decreased by approximately 13%. The overall thinning rate of Pedersenbreen has shown acceleration during the recent decades. Further analysis shows that the ice tongue in the downstream area of Pedersenbreen is melting at the highest rate, while a simultaneous accumulation occurred in the upstream. However, as global temperatures increase, the accumulation area is reducing year by year.AI SongTao WANG ZeMin TAN Zhi E DongChen YAN Ming 2013Chinese Science Bulletin2013,58,25:5
14A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species.Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian 2022Cell Research2022,32,10:3
15New Minor Cyclopeptides from Arenaria oreophila (Caryophyllaceae)显示文摘新次要的周期的肽,命名 arenariphilin C 1 和 arenariphilin D 2,从 Arenaria oreophila (石竹科) 的整个植物被孤立。他们的结构我们 redetermined 作为出租机动三轮车(Pro^1-Pro^2-Leu^1-Leu^2-Phe-Ser-Gly-Thr ) 和出租机动三轮车(Ser-Cys ) 根据分光镜的数据,特别由二尺寸的 NMR (2D NMR ) 技术。Ai Qun JIA Ning Hua TAN Jun ZHOU 2006Chinese Chemical Letters2006,17,4:3
16Anti-hypercholesterolemic effect of kenaf(Hibiscus cannabinus L.)seed on high-fat diet Sprague dawley rats显示文摘Objective:To determine? the anlihypercholesterolemic effects of kenaf seed samples and compare with the commercial hypocholesterolemic drug on serum lipids profiles and malondialdehyde(MDA) level in the rat.Methods:Kenaf seed oil(KSO),microencapsulated kenaf seed oil(MKSO),kenaf seed extract(KSE) and defatted kenaf seed meal(DKSM) were prepared and phytocHemicals screening on these samples were done prior in viro study.Phenolic compounds in KSF.were quantified using high performance liquid chromatography.There were 40(divided in eight diet groups of 5) male Sprague dawley rats adapted lo normal standard diet or hypercholesterolemic diet(HD) with or without the treatment of these kenaf samples for 32 days.Results:All the kenaf samples exhibited to contain most of the major phytocliemicals.KSE possessed gallic acid,tannic acid,catechin.benzaldehyde.benzoic acid,syringic acid,sinapic acid,ferulic acid,naringin acid,and protocatechuic acid.The significant higher(P<0.05) serum total cholesterol,low density lipoprotein cholesterol and MDA levels in HD group without treatment than the normal control group suggested the hypercholesterolemia was induced by the Incorporation of cholesterol into diet.KSE exhibited higher cholesterol-lowering properties due to the significant lower(P<0.05)in serum triglycerides,total cholesterol and MDA levels.KSF showed the highest efficiency of cholesterol-lowering activity,followed by KSO.MKSO and DKSM.Conclusions:DKSM.MKSO.KSO and KSE appeared lo have comparable anti-hypercholesterolemic effect with the commercial hypocholesterolemic drug.Hence,kenaf seed could be used as an alternative natural source lo replace the synthetic hypocholosterolemic drugs.Ng Shy Kai Tee Ai Nee Elaine Lai Chia Ling Tan Chin Ping Long Kamariah Nyam Kar Lin 2015Asian Pacific Journal of Tropical Medicine2015,8,1:2
17Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin 2022Signal Transduction and Targeted Therapy2022,7,3:2
18Hyperhomocysteinemia and impaired vasomotor function in type 2 diabetesmellitus显示文摘Tan KC O K Chow WS Ai VH 2002Eur J Clin Invest2002,32,5:1
19MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation显示文摘Huan Sun Qing-Wei Li Xiao-Yan Lv Jian-Zhong Ai Qiu-Tan Yang Jing-Jing Duan Guo-Hui Bian Yan Xiao Yi-Dong Wang Zheng Zhang Yu-Hang Liu Rui-Zhi Tan Yang Yang Yu-Quan Wei Qin Zhou 2010Molecular Biology Reports2010,,6:1
20Inhibition of integrin linked kinase ( ILK ) suppresses bera-catenin-Lef / Tcf- dependent transcription and expression of the E-cadherin repressor, snail, in APC-/-human colon carcinoma cells 显示文摘Tan C Costello P Sanghera J et ai 2001Oncogene2001,20,1:1
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