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| 1 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 2 | Decomposition of Polycyclic Aromatic Hydrocarbon (PAHs) on Mineral Surface under Controlled Relative Humidity显示文摘多不的芳香的烃的命运(哼) 居住在空气在最近的年里收到了庞大的注意由于他们的诱变并且人的健康上的 carcinogenicrisks。在这上下文,分核的稳定性(当一个代表哼) 在石英,氧化铝,胶岭石,高岭石,腐殖酸和与 sorbed 涂的石英上,腐殖酸在控制相对湿度被调查(RH:即 5% 和 30%) 没有轻照耀以便在 PAHsdecomposition 上检测矿物质表面的催化效果的存在。分核的稳定性被发现强烈取决于底层的物理化学性质。尽管它与 sorbed 腐殖酸是涂的,石英为分核的分解显示出强壮的催化效果。蒙脱石和腐殖酸上的分核 sorbed 在试验性的时期期间仍然保持稳定(即 3 天) 。在试验性的房间的潮湿也特别地影响了分核的稳定性矿物质。特别,氧化铝上的分核 sorbed 很快在更高的 RH 被分解。然而,有几乎不在石英,高岭石和腐殖酸的情况中完成。取决于喷雾器和 RH 的物理化学性质,有在空气的矿物质的 PAHsassociated 将被分解或稳定地居住在空气。 | Shuji TAMAMURA Tsutomu SATO Yukie OTA Ning TANG Kazuichi HAYAKAWA | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 2 |
| 3 | Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ((Tyr5,12, Lys7)-polyphemusin II).显示文摘 | Tamamura HR | | 0，，： | 1 |
| 4 | Adult patient with mandibular protrusion and unstable occlusion treated with titanium screw anchorage显示文摘 | SUGAWARA Y KURODA S TAMAMURA N | 2008 | Am J Orthod Dentofacial Orthop2008，133，1： | 1 |
| 5 | Development of selective antagonists against an HIV second receptor 显示文摘 | Tamamura H Tamamura H | 2001 | YakugakukoZasshi2001，121，11： | 1 |
| 6 | Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics显示文摘 | TAMAMURA T SATO K | 1999 | Jpn J Antibiot1999，52，1： | 1 |
| 7 | Anterior open-bite with temporomandibular disorder treated with titanium screw anchorage:evaluation of morphological and functional improvement显示文摘 | Kuroda S Sugawara Y Tamamura N | 2007 | American Journal of Orthodontics and Dentofacial Orthopedics2007，131，4： | 1 |
| 8 | Rapid phenotypic changes in passaged articular chondrocyte subpopulations显示文摘 | Tamamura Y Iwamoto M | 2004 | Clin Calcium2004，14，7： | 1 |
| 9 | Protective effect of edara- vone, a free-radical scavenger, on ischaemia-repeffusion injury in the rat testis显示文摘 | Tamamura M Saito M Kinoshita Y | 2010 | BJU Int2010，105，6： | 1 |
| 10 | T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer显示文摘 | Tamamura H Hori A Kanzaki N | 2003 | FEBS Lett2003，550，13： | 1 |
| 11 | Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 (-polyphemusin Ⅱ),which specifically blocks T cell-line-tropic HIV-1 infection显示文摘 | Tamamura H Imai M Ishihara T | 1998 | Bioorg Med Chem1998，6，： | 1 |
| 12 | A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22(-polyphe- musin II), determined by nuclear magnetic resonance 显示文摘 | Tamamura H Kuroda M Masuda M | 1993 | Biochim BiophysActa1993，1163，2： | 1 |
| 13 | T134, a smallmolecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure显示文摘 | Arakaki R Tamamura H Premanathan M | 1999 | J Virol1999，73，2： | 1 |
| 14 | Role of CCN,a vertebrate specific gene family,in development显示文摘 | Katsube K Sakamoto K Tamamura Y | 2009 | Dev Growth Differ2009，51，1： | 1 |
| 15 | T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer显示文摘 | Tamamura H Hori A Kanzaki N | 2003 | FEBS Lett2003，550，13： | 1 |
| 16 | Adult patient with mandibular protrusion and unstable occlusion treated with titanium screw anchorage显示文摘 | Yasuyo Sugawara Shingo Kuroda Nagato Tamamura | 2008 | Am J Orthod Dentofacial Orthop2008，133，1： | 1 |
| 17 | Anterior open bite with temporomandibular disorder treated with titanium screw anchorage:evaluation of morphological and functional improvement显示文摘 | Kuroda S Sugawara Y Tamamura N | | 0，，： | 1 |
| 18 | Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies显示文摘 | Tamamura H Kato T Otaka A | 2003 | Org Biomol Chem2003，1，14： | 1 |
| 19 | Role of CCN, a verte- brate specific gene family, in development 显示文摘 | Katsube K Sakamoto K Tamamura Y | 2009 | Dev Growth Differ2009，51，： | 1 |
| 20 | Pharmacophore identification of a chemokine receptor (CXCR4) antagonist,T22 (-polyphemusin Ⅱ),which specifically blocks T cell-line-tropic HIV-1 infection 显示文摘 | Imai M Ishihara T | 1998 | Bioorg Med Chem1998，6，7： | 1 |
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