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| 1 | Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering显示文摘 | Maryam Tamaddon Ling Wang Ziyu Liu Chaozong Liu | 2018 | Bio-Design and Manufacturing2018，1，2： | 5 |
| 2 | Design and performance evaluation of additively manufactured composite lattice structures of commercially pure Ti(CP-Ti)显示文摘Ti alloys with lattice structures are garnering more and more attention in the field of bone repair or regeneration due to their superior structural,mechanical,and biological properties.In this study,six types of composite lattice structures with different strut radius that consist of simple cubic(structure A),body-centered cubic(structure B),and edge-centered cubic(structure C)unit cells are designed.The designed structures are firstly simulated and analysed by the finite element(FE)method.Commercially pure Ti(CP-Ti)lattice structures with optimized unit cells and strut radius are then fabricated by selective laser melting(SLM),and the dimensions,microtopography,and mechanical properties are characterised.The results show that among the six types of composite lattice structures,combined BA,CA,and CB structures exhibit smaller maximum von-Mises stress,indicating that these structures have higher strength.Based on the fitting curves of stress/specific surface area versus strut radius,the optimized strut radius of BA,CA,and CB structures is 0.28,0.23,and 0.30 mm respectively.Their corresponding compressive yield strength and compressive modulus are 42.28,30.11,and 176.96 MPa,and 4.13,2.16,and 7.84 GPa,respectively.The CP-Ti with CB unit structure presents a similar strength and compressive modulus to the cortical bone,which makes it a potential candidate for subchondral bone restorations. | Wei Xu Aihua Yu Xin Lu Maryam Tamaddon Mengdi Wang Jiazhen Zhang Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su | 2021 | Bioactive Materials2021，6，5： | 2 |
| 3 | Redox-sensitive, PEG-shielded carboxymethyl PEI nanogels silencing MicroRNA-21, sensitizes resistant ovarian cancer cells to cisplatin显示文摘A series of branched polyethylenimine(PEI) modifications including PEGylation(PEG2 k-PEI) for steric shielding, redox-sensitive crosslinking for synthesis PEG2 k-PEI-ss nanogels and subsequent carboxymethylation(PEG2 k-CMPEI-ss) for modulation of the polymer pk a have been introduced for cellular delivery of Anti-mi R-21. The synthesis was characterized using 1 H NMR, FTIR, TNBS, potentiometric titration, particle size and ζ potential. Loading of Anti-mi R-21 at various N/P ratios was investigated by gel retardation, ethidium bromide dye exclusion, heparin sulfate competition and DNase I digestion experiments. The mi R-21 silencing was measured by stem-loop RT PCR in A2780 ovarian cancer cell lines whether it is sensitive to resistant to cisplatin. It has been shown that PEG2 k-CMPEI-ss was well suited for delivery of Anti-mi R-21 in terms of nucleic acid loading, preservation against extracellular matrix and nucleases and sequence-specific silencing of mi RNA-21 in vitro. Moreover, it has been demonstrated that pre-treating cells with Anti-mi R-21 loaded nanogels can sensitize them to cis-Pt even at non-toxic concentraions. The results indicate that PEG2 k-CMPEIss mediated micro RNA delivery can be considered as a novel strategy for ovarian cancer therapy. | Sanaz Javanmardi Ali Mohammad Tamaddon Mahmoud Reza Aghamaali Ladan Ghahramani Samira Sadat Abolmaali | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 2 |
| 4 | Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications显示文摘When biomaterials are implanted in the human body,the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation,causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery.Ti-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement,and the prevention of infection of Ti-Mo implants is therefore crucial.In this study,bacterial inhibitory copper(Cu)was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory property.The effects of Cu content on microstructure,tensile properties,cytocompatibility,and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically investigated.Results revealed that Ti-10Mo-1Cu alloy consisted ofαandβphases,while there were a few Ti2Cu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys,in addition toαandβphases.The tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation decreased.Ti-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%.Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation.Bacterial inhibitory rates against S.aureus and E.coli increased with the increase in Cu content of Ti-10Mo-xCu alloy,within the ranges of 20-60%and 15-50%,respectively.Taken together,this study suggests that Ti-10Mo-3Cu alloy with high strength,acceptable elongation,excellent cytocompatibility,and the bacterial inhibitory property is a promising candidate for biomedical implant applications. | Wei Xu Chenjin Hou Yuxuan Mao Lei Yang Maryam Tamaddon Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Xin Lu | 2020 | Bioactive Materials2020，5，3： | 2 |
| 5 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 6 | Comduction slowing and sudden arrhythmic death in mice with cardiac - restricted Inactiva- tion of connexin 43 显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，3： | 1 |
| 7 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，： | 1 |
| 8 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin 43 显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，3： | 1 |
| 9 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，： | 1 |
| 10 | Conduction slowing and sudden arrhythmic death in mice with cardiac restricted in activation of connexind-3显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，3： | 1 |
| 11 | 查看详情显示文摘 | Tamaddon F Razmi Z Jafari A.A | | 0，，： | 1 |
| 12 | Heavy metals in a municipal solid waste deposition cell显示文摘 | Flyhammar P Tamaddon F Bengtsson L | 1998 | Waste Management&Research1998，16，5： | 1 |
| 13 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，： | 1 |
| 14 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，3： | 1 |
| 15 | Hydrogenation assisted nickel-induced lateral nano-crystallization of amorphous silicon on flexible plastic substrates at low temperatures显示文摘 | PAYDAVOSI S EBRAHIMI A TAMADDON A H | 2008 | Thin Solid Films2008，516，21： | 1 |
| 16 | Clinical and experimental evidence of prostagland in E1-induced angiogenesis in the myocardium of patients with ischemic heart disesse显示文摘 | Mehrabi MR Serbecic N Tamaddon F | 2002 | Cardiovasc Res2002，56，： | 1 |
| 17 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43显示文摘 | GUTSTEIN D E MORLEY G E TAMADDON H | 2001 | Circ Res2001，88，： | 1 |
| 18 | Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints:from bench to clinic显示文摘Osteoarthritis is a degenerative joint disease,typified by the loss in the quality of cartilage and bone at the interface of a synovial joint,resulting in pain,stiffness and reduced mobility.The current surgical treatment for advanced stages of the disease is joint replacement,where the non-surgical therapeutic options or less invasive surgical treatments are no longer effective.These are major surgical procedures which have a substantial impact on patients’quality of life and lifetime risk of requiring revision surgery.Treatments using regenerative methods such as tissue engineering methods have been established and are promising for the early treatment of cartilage degeneration in osteoarthritis joints.In this approach,3-dimensional scaffolds(with or without cells)are employed to provide support for tissue growth.However,none of the currently available tissue engineering and regenerative medicine products promotes satisfactory durable regeneration of large cartilage defects.Herein,we discuss the current regenerative treatment options for cartilage and osteochondral(cartilage and underlying subchondral bone)defects in the articulating joints.We further identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral tissues.The evolution of the osteochondral scaffolds–from monophasic to multiphasic constructs–is overviewed and the osteochondral scaffolds that have progressed to clinical trials are examined with respect to their clinical performances and their potential impact on the clinical practices.Development of an osteochondral scaffold which bridges the gap between small defect treatment and joint replacement is still a grand challenge.Such scaffold could be used for early treatment of cartilage and osteochondral defects at early stage of osteoarthritis and could either negate or delay the need for joint replacements. | Maryam Tamaddon Helena Gilja Ling Wang JMiguel Oliveira Xiaodan Sun Rongwei Tan Chaozong Liu | 2020 | Biomaterials Translational2020，1，1： | 1 |
| 19 | Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 显示文摘 | Gutstein DE Morley GE Tamaddon H | 2001 | Circ Res2001，88，： | 1 |
| 20 | Prospective randomized study of various techniques of percutaneous nephrolithotomy显示文摘 | Feng MI Tamaddon K Mikhail A | 2001 | Urology2001，58，3： | 1 |
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